SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i1s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E73_M_ASCM995_0
(MYROSINASE MA1)		 4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Sus
scrofa) 		4 / 6 ILE A 619
TYR A 622
PHE A 549
PHE A 677
 None
 1.47A 1e73M-4i1sA:
undetectable		 1e73M-4i1sA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 4i1s NON-STRUCTURAL
PROTEIN V
(Mammalian
rubulavirus
5) 		3 / 3 CYH B 190
ARG B 203
CYH B 218
 ZN  B 302 (-2.4A)
None
ZN  B 302 (-2.2A)
 1.34A 1p9gA-4i1sB:
undetectable		 1p9gA-4i1sB:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 4i1s NON-STRUCTURAL
PROTEIN V
(Mammalian
rubulavirus
5) 		3 / 3 CYH B 218
ARG B 173
CYH B 215
 ZN  B 302 (-2.2A)
None
ZN  B 302 (-2.2A)
 1.34A 1p9gA-4i1sB:
undetectable		 1p9gA-4i1sB:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Sus
scrofa) 		4 / 8 LYS A 681
LEU A 684
PHE A 549
LEU A 553
 None
 0.63A 1v54C-4i1sA:
2.3
1v54J-4i1sA:
undetectable		 1v54C-4i1sA:
19.63
1v54J-4i1sA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Sus
scrofa) 		4 / 8 LYS A 681
LEU A 684
PHE A 549
LEU A 553
 None
 0.62A 1v54P-4i1sA:
2.3
1v54W-4i1sA:
undetectable		 1v54P-4i1sA:
19.63
1v54W-4i1sA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Sus
scrofa) 		4 / 8 LYS A 681
LEU A 684
PHE A 549
LEU A 553
 None
 0.63A 2dyrC-4i1sA:
2.3
2dyrJ-4i1sA:
undetectable		 2dyrC-4i1sA:
19.63
2dyrJ-4i1sA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Sus
scrofa) 		4 / 8 LYS A 681
LEU A 684
PHE A 549
LEU A 553
 None
 0.60A 2dyrP-4i1sA:
2.3
2dyrW-4i1sA:
undetectable		 2dyrP-4i1sA:
19.63
2dyrW-4i1sA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Sus
scrofa) 		4 / 8 LYS A 681
LEU A 684
PHE A 549
LEU A 553
 None
 0.60A 2eikP-4i1sA:
2.3
2eikW-4i1sA:
undetectable		 2eikP-4i1sA:
19.63
2eikW-4i1sA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Sus
scrofa) 		4 / 8 LYS A 681
LEU A 684
PHE A 549
LEU A 553
 None
 0.73A 2eilC-4i1sA:
2.3
2eilJ-4i1sA:
undetectable		 2eilC-4i1sA:
19.63
2eilJ-4i1sA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Sus
scrofa) 		4 / 7 LYS A 681
LEU A 684
PHE A 549
LEU A 553
 None
 0.72A 2eimP-4i1sA:
2.2
2eimW-4i1sA:
undetectable		 2eimP-4i1sA:
19.63
2eimW-4i1sA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
NON-STRUCTURAL
PROTEIN V
(Mammalian
rubulavirus
5;
Sus
scrofa) 		4 / 6 HIS A 708
PHE A 709
ARG B 172
GLY A 718
 None
 1.23A 2i30A-4i1sA:
2.7		 2i30A-4i1sA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Sus
scrofa) 		5 / 12 LEU A 731
ALA A 748
GLY A 718
ILE A 800
ILE A 784
 None
 1.09A 2o4kA-4i1sA:
undetectable		 2o4kA-4i1sA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Sus
scrofa) 		3 / 3 ASP A 571
PHE A 572
LEU A 610
 None
 0.58A 2zi9A-4i1sA:
2.5		 2zi9A-4i1sA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Sus
scrofa) 		4 / 7 LYS A 681
LEU A 684
PHE A 549
LEU A 553
 None
 0.57A 3asnP-4i1sA:
2.3
3asnW-4i1sA:
undetectable		 3asnP-4i1sA:
19.63
3asnW-4i1sA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Sus
scrofa) 		4 / 7 LYS A 681
LEU A 684
PHE A 549
LEU A 553
 None
 0.55A 3asoP-4i1sA:
2.3
3asoW-4i1sA:
undetectable		 3asoP-4i1sA:
19.63
3asoW-4i1sA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 4i1s NON-STRUCTURAL
PROTEIN V
(Mammalian
rubulavirus
5) 		3 / 3 CYH B 215
CYH B 190
HIS B 171
 ZN  B 302 (-2.2A)
ZN  B 302 (-2.4A)
ZN  B 302 (-3.0A)
 0.83A 3dtuB-4i1sB:
undetectable		 3dtuB-4i1sB:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 4i1s NON-STRUCTURAL
PROTEIN V
(Mammalian
rubulavirus
5) 		3 / 3 CYH B 215
CYH B 190
HIS B 171
 ZN  B 302 (-2.2A)
ZN  B 302 (-2.4A)
ZN  B 302 (-3.0A)
 0.80A 3dtuD-4i1sB:
undetectable		 3dtuD-4i1sB:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_1
(PROTEASE)		 4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Sus
scrofa) 		5 / 11 LEU A 731
ALA A 748
GLY A 718
ILE A 800
ILE A 784
 None
 1.06A 3el1A-4i1sA:
undetectable		 3el1A-4i1sA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)		 4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Sus
scrofa) 		5 / 12 LEU A 731
ALA A 748
GLY A 718
ILE A 800
ILE A 784
 None
 1.12A 3mwsB-4i1sA:
undetectable		 3mwsB-4i1sA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Sus
scrofa) 		5 / 12 LEU A 610
THR A 558
PRO A 568
SER A 570
LEU A 554
 None
 1.21A 3nrrA-4i1sA:
undetectable		 3nrrA-4i1sA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Sus
scrofa) 		6 / 10 LEU A 731
ALA A 748
GLY A 718
ILE A 800
THR A 722
ILE A 784
 None
 1.14A 4njuB-4i1sA:
undetectable		 4njuB-4i1sA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)		 4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Sus
scrofa) 		6 / 10 LEU A 731
ALA A 748
GLY A 718
ILE A 800
THR A 722
ILE A 784
 None
 1.14A 4njuD-4i1sA:
undetectable		 4njuD-4i1sA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Sus
scrofa) 		5 / 11 ILE A 556
HIS A 602
LEU A 603
LEU A 673
LEU A 625
 None
 1.09A 4p65E-4i1sA:
undetectable
4p65F-4i1sA:
undetectable
4p65J-4i1sA:
undetectable
4p65L-4i1sA:
undetectable		 4p65E-4i1sA:
5.13
4p65F-4i1sA:
7.92
4p65J-4i1sA:
7.92
4p65L-4i1sA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Sus
scrofa) 		5 / 11 ILE A 556
LEU A 610
ALA A 609
LEU A 603
LEU A 625
 None
 1.09A 4p65E-4i1sA:
undetectable
4p65F-4i1sA:
undetectable
4p65J-4i1sA:
undetectable
4p65L-4i1sA:
undetectable		 4p65E-4i1sA:
5.13
4p65F-4i1sA:
7.92
4p65J-4i1sA:
7.92
4p65L-4i1sA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Sus
scrofa) 		5 / 12 LEU A 673
LEU A 625
ILE A 556
HIS A 602
LEU A 603
 None
 1.00A 4p65B-4i1sA:
undetectable
4p65D-4i1sA:
undetectable
4p65I-4i1sA:
undetectable
4p65J-4i1sA:
undetectable		 4p65B-4i1sA:
7.92
4p65D-4i1sA:
7.92
4p65I-4i1sA:
5.13
4p65J-4i1sA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Sus
scrofa) 		5 / 12 LEU A 625
LEU A 673
ILE A 556
HIS A 602
LEU A 603
 None
 0.98A 4p65F-4i1sA:
undetectable
4p65H-4i1sA:
undetectable
4p65K-4i1sA:
undetectable
4p65L-4i1sA:
undetectable		 4p65F-4i1sA:
7.92
4p65H-4i1sA:
7.92
4p65K-4i1sA:
5.13
4p65L-4i1sA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Sus
scrofa) 		3 / 3 PHE A 741
THR A 722
LEU A 698
 None
 0.78A 4qztA-4i1sA:
undetectable		 4qztA-4i1sA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Sus
scrofa) 		4 / 6 LYS A 681
LEU A 684
PHE A 549
LEU A 553
 None
 0.67A 5x19P-4i1sA:
2.3		 5x19P-4i1sA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5
(Sus
scrofa) 		4 / 7 LYS A 681
LEU A 684
PHE A 549
LEU A 553
 None
 0.70A 5x1fP-4i1sA:
undetectable
5x1fW-4i1sA:
undetectable		 5x1fP-4i1sA:
19.63
5x1fW-4i1sA:
13.27