SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i1t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 4i1t RNA-DIRECTED RNA
POLYMERASE L
(Cali
mammarenavirus) 		5 / 12 TYR A 146
LEU A  49
LEU A  46
TYR A 150
ILE A 151
 None
 1.26A 1fmlA-4i1tA:
undetectable		 1fmlA-4i1tA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4i1t RNA-DIRECTED RNA
POLYMERASE L
(Cali
mammarenavirus) 		3 / 3 LEU A 100
LEU A 125
MET A 123
 None
 0.75A 2itzA-4i1tA:
undetectable		 2itzA-4i1tA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA601_0
(LACCASE-1)		 4i1t RNA-DIRECTED RNA
POLYMERASE L
(Cali
mammarenavirus) 		4 / 5 HIS A  58
CYH A  60
ILE A  98
LEU A 100
 None
 1.20A 3qpkA-4i1tA:
undetectable		 3qpkA-4i1tA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4i1t RNA-DIRECTED RNA
POLYMERASE L
(Cali
mammarenavirus) 		4 / 7 PRO A  87
LEU A 125
LEU A 129
ILE A  71
 None
 0.88A 3u5jA-4i1tA:
3.1		 3u5jA-4i1tA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4i1t RNA-DIRECTED RNA
POLYMERASE L
(Cali
mammarenavirus) 		4 / 8 PRO A  87
LEU A 125
LEU A 129
ILE A  71
 None
 0.79A 3u5kA-4i1tA:
3.1		 3u5kA-4i1tA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4i1t RNA-DIRECTED RNA
POLYMERASE L
(Cali
mammarenavirus) 		4 / 7 PRO A  87
LEU A 125
LEU A 129
ILE A  71
 None
 0.95A 3u5kB-4i1tA:
3.1		 3u5kB-4i1tA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4i1t RNA-DIRECTED RNA
POLYMERASE L
(Cali
mammarenavirus) 		4 / 8 PRO A  87
LEU A 125
LEU A 129
ILE A  71
 None
 0.89A 3u5kC-4i1tA:
2.7		 3u5kC-4i1tA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4i1t RNA-DIRECTED RNA
POLYMERASE L
(Cali
mammarenavirus) 		4 / 8 PRO A  87
LEU A 125
LEU A 129
ILE A  71
 None
 0.91A 3u5kD-4i1tA:
2.9		 3u5kD-4i1tA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4i1t RNA-DIRECTED RNA
POLYMERASE L
(Cali
mammarenavirus) 		3 / 3 ASP A 118
ARG A 105
LYS A 114
 None
 1.26A 3wipG-4i1tA:
undetectable		 3wipG-4i1tA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 4i1t RNA-DIRECTED RNA
POLYMERASE L
(Cali
mammarenavirus) 		4 / 6 THR A  64
ASN A  63
ARG A  65
GLU A  74
 None
 1.20A 5uigA-4i1tA:
3.3		 5uigA-4i1tA:
18.04