SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i2o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 4i2o FIXK2 PROTEIN
(Bradyrhizobium
japonicum) 		4 / 5 GLY A 188
LEU A 191
ARG A 160
VAL A 198
 None
 1.07A 1ekjF-4i2oA:
undetectable
1ekjG-4i2oA:
undetectable		 1ekjF-4i2oA:
20.16
1ekjG-4i2oA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 4i2o FIXK2 PROTEIN
(Bradyrhizobium
japonicum) 		5 / 11 THR A 138
GLU A  95
LEU A 120
GLY A  93
GLU A 141
 None
 1.47A 1i7qA-4i2oA:
undetectable		 1i7qA-4i2oA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 4i2o FIXK2 PROTEIN
(Bradyrhizobium
japonicum) 		5 / 12 ALA A 162
ALA A 201
THR A 197
GLY A 192
GLN A  81
 None
 1.29A 2ve3B-4i2oA:
undetectable		 2ve3B-4i2oA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 4i2o FIXK2 PROTEIN
(Bradyrhizobium
japonicum) 		5 / 11 ALA A 179
LEU A 180
ARG A 217
ARG A 184
GLY A 215
 None
 1.50A 3bpxA-4i2oA:
4.7
3bpxB-4i2oA:
3.8		 3bpxA-4i2oA:
22.13
3bpxB-4i2oA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4i2o FIXK2 PROTEIN
(Bradyrhizobium
japonicum) 		4 / 7 GLY A 192
HIS A 148
ILE A 187
VAL A 198
 None
 0.72A 3fi0E-4i2oA:
undetectable		 3fi0E-4i2oA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4i2o FIXK2 PROTEIN
(Bradyrhizobium
japonicum) 		4 / 8 GLY A 192
HIS A 148
ILE A 187
VAL A 198
 None
 0.71A 3fi0G-4i2oA:
undetectable		 3fi0G-4i2oA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4i2o FIXK2 PROTEIN
(Bradyrhizobium
japonicum) 		4 / 8 GLY A 192
HIS A 148
ILE A 187
VAL A 198
 None
 0.76A 3fi0Q-4i2oA:
undetectable		 3fi0Q-4i2oA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4i2o FIXK2 PROTEIN
(Bradyrhizobium
japonicum) 		4 / 7 ARG A 170
LEU A 180
ILE A  82
PHE A  85
 None
 1.01A 3ln1C-4i2oA:
undetectable		 3ln1C-4i2oA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4i2o FIXK2 PROTEIN
(Bradyrhizobium
japonicum) 		4 / 5 ARG A 170
LEU A 180
ILE A  82
PHE A  85
 None
 1.01A 3ln1D-4i2oA:
undetectable		 3ln1D-4i2oA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 4i2o FIXK2 PROTEIN
(Bradyrhizobium
japonicum) 		4 / 6 TYR A  52
VAL A  69
HIS A  86
SER A  71
 None
 1.06A 3tj7C-4i2oA:
undetectable
3tj7D-4i2oA:
undetectable		 3tj7C-4i2oA:
21.01
3tj7D-4i2oA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 4i2o FIXK2 PROTEIN
(Bradyrhizobium
japonicum) 		4 / 6 VAL A  69
HIS A  86
SER A  71
TYR A  52
 None
 1.07A 3tj7C-4i2oA:
undetectable
3tj7D-4i2oA:
undetectable		 3tj7C-4i2oA:
21.01
3tj7D-4i2oA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 4i2o FIXK2 PROTEIN
(Bradyrhizobium
japonicum) 		5 / 9 TYR A  52
ALA A 106
TYR A  45
GLY A  93
PHE A  92
 None
 1.13A 4mmeB-4i2oA:
undetectable		 4mmeB-4i2oA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4i2o FIXK2 PROTEIN
(Bradyrhizobium
japonicum) 		4 / 4 ARG A 170
HIS A 148
ALA A  84
GLU A 167
 None
 1.45A 5a06A-4i2oA:
undetectable
5a06F-4i2oA:
undetectable		 5a06A-4i2oA:
21.25
5a06F-4i2oA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUQ_A_ACTA1278_0
(NAD(P)H
DEHYDROGENASE
[QUINONE] 1)		 4i2o FIXK2 PROTEIN
(Bradyrhizobium
japonicum) 		4 / 5 HIS A  86
SER A  71
ILE A  51
TYR A  62
 None
 1.21A 5fuqA-4i2oA:
undetectable
5fuqB-4i2oA:
undetectable		 5fuqA-4i2oA:
22.70
5fuqB-4i2oA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4i2o FIXK2 PROTEIN
(Bradyrhizobium
japonicum) 		5 / 12 VAL A 112
SER A  44
THR A 110
PHE A  92
ALA A 106
 None
 1.33A 6drxA-4i2oA:
undetectable		 6drxA-4i2oA:
17.92