SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i2w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		5 / 11 SER A 669
LEU A 554
LEU A 642
CYH A 651
ILE A 595
 None
 1.26A 1ee2A-4i2wA:
undetectable		 1ee2A-4i2wA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		4 / 5 LEU A 574
GLU A 644
ALA A 647
LEU A 577
 None
 1.19A 1eta1-4i2wA:
undetectable		 1eta1-4i2wA:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		4 / 5 LEU A 574
GLU A 644
ALA A 647
LEU A 577
 None
 1.19A 1eta2-4i2wA:
undetectable		 1eta2-4i2wA:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		4 / 7 SER A 659
SER A 669
PHE A 603
ALA A 593
 None
 1.23A 1fxvA-4i2wA:
undetectable
1fxvB-4i2wA:
undetectable		 1fxvA-4i2wA:
12.90
1fxvB-4i2wA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		5 / 9 LEU A 168
THR A 215
ILE A 216
THR A 205
ILE A 209
 None
 1.22A 1hzeA-4i2wA:
undetectable
1hzeB-4i2wA:
undetectable		 1hzeA-4i2wA:
7.63
1hzeB-4i2wA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		5 / 9 THR A 205
ILE A 209
LEU A 168
THR A 215
ILE A 216
 None
 1.22A 1hzeA-4i2wA:
undetectable
1hzeB-4i2wA:
undetectable		 1hzeA-4i2wA:
7.63
1hzeB-4i2wA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		5 / 10 LEU A 168
THR A 215
ILE A 216
THR A 205
ILE A 209
 None
 1.24A 1i18A-4i2wA:
undetectable
1i18B-4i2wA:
undetectable		 1i18A-4i2wA:
7.63
1i18B-4i2wA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		5 / 10 THR A 205
ILE A 209
LEU A 168
THR A 215
ILE A 216
 None
 1.24A 1i18A-4i2wA:
undetectable
1i18B-4i2wA:
undetectable		 1i18A-4i2wA:
7.63
1i18B-4i2wA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LF9_A_ACRA700_2
(GLUCOAMYLASE)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		4 / 4 TRP A 783
GLU A 780
TRP A 823
LEU A 820
 None
 1.33A 1lf9A-4i2wA:
2.1		 1lf9A-4i2wA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		4 / 5 GLU A 173
LEU A 167
LEU A 170
LEU A 168
 None
 1.07A 1np1A-4i2wA:
undetectable		 1np1A-4i2wA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		3 / 3 LEU A 322
PHE A 337
ARG A 311
 None
 0.69A 1xdkF-4i2wA:
undetectable		 1xdkF-4i2wA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		3 / 3 SER A 111
ASP A  80
CYH A  70
 None
 1.13A 2br4E-4i2wA:
undetectable		 2br4E-4i2wA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		3 / 3 LYS A 274
ASP A 213
CYH A 171
 None
 1.26A 2br4F-4i2wA:
undetectable		 2br4F-4i2wA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		4 / 7 LEU A 373
GLN A 374
LEU A 347
PHE A 420
 None
 1.06A 2dysP-4i2wA:
2.3
2dysW-4i2wA:
undetectable		 2dysP-4i2wA:
14.04
2dysW-4i2wA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		4 / 7 LEU A 373
GLN A 374
LEU A 347
PHE A 420
 None
 0.91A 2eikC-4i2wA:
2.3
2eikJ-4i2wA:
undetectable		 2eikC-4i2wA:
14.04
2eikJ-4i2wA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		4 / 8 LEU A 373
GLN A 374
LEU A 347
PHE A 420
 None
 0.91A 2eilC-4i2wA:
2.3
2eilJ-4i2wA:
undetectable		 2eilC-4i2wA:
14.04
2eilJ-4i2wA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_2
(PROTEASE)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		5 / 12 ALA A 255
ASP A 254
ASP A 251
VAL A 191
ILE A 209
 None
 0.90A 2ienB-4i2wA:
undetectable		 2ienB-4i2wA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		5 / 12 ALA A 710
LEU A 714
ALA A 712
THR A 755
GLN A 727
 None
 1.24A 2jjpA-4i2wA:
undetectable		 2jjpA-4i2wA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDM_B_AGGB1462_1
(INTEGRIN ALPHA-IIB
INTEGRIN BETA-3)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		5 / 12 PHE A  85
LEU A  74
ASP A  80
ARG A 123
ALA A  90
 None
 1.38A 2vdmA-4i2wA:
undetectable
2vdmB-4i2wA:
undetectable		 2vdmA-4i2wA:
18.49
2vdmB-4i2wA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		4 / 6 ALA A 710
ALA A 712
THR A 755
PHE A 724
 None
 0.92A 2xfhA-4i2wA:
undetectable		 2xfhA-4i2wA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		4 / 6 LEU A 373
GLN A 374
LEU A 347
PHE A 420
 None
 0.93A 2zxwP-4i2wA:
undetectable
2zxwW-4i2wA:
undetectable		 2zxwP-4i2wA:
14.04
2zxwW-4i2wA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		4 / 6 LEU A 373
GLN A 374
LEU A 347
PHE A 420
 None
 0.89A 3ag1C-4i2wA:
undetectable
3ag1J-4i2wA:
undetectable		 3ag1C-4i2wA:
14.04
3ag1J-4i2wA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		4 / 8 LEU A 373
GLN A 374
LEU A 347
PHE A 420
 None
 0.89A 3ag4C-4i2wA:
2.3
3ag4J-4i2wA:
undetectable		 3ag4C-4i2wA:
14.04
3ag4J-4i2wA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		4 / 7 LEU A 373
GLN A 374
LEU A 347
PHE A 420
 None
 0.91A 3ag4P-4i2wA:
undetectable
3ag4W-4i2wA:
undetectable		 3ag4P-4i2wA:
14.04
3ag4W-4i2wA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		6 / 12 LEU A 212
ALA A 255
ASP A 254
ASP A 251
VAL A 191
ILE A 209
 None
 1.16A 3cywA-4i2wA:
undetectable		 3cywA-4i2wA:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		6 / 12 THR A 847
ASN A 851
ASP A 849
ILE A 886
GLY A 882
LEU A 896
 None
 1.49A 3eeyI-4i2wA:
undetectable		 3eeyI-4i2wA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		5 / 12 PHE A 264
THR A 256
VAL A 253
VAL A 293
LEU A 294
 None
 1.28A 3elzA-4i2wA:
undetectable		 3elzA-4i2wA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		5 / 12 LEU A 753
LEU A 799
THR A 812
ILE A 770
ILE A 776
 None
 1.09A 3ut5B-4i2wA:
undetectable		 3ut5B-4i2wA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		5 / 12 ILE A 433
LEU A 446
ILE A 475
VAL A 484
LEU A 485
 None
 1.06A 3w67B-4i2wA:
undetectable		 3w67B-4i2wA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		3 / 3 ARG A 221
ASP A 271
GLN A 273
 None
 0.91A 4azsA-4i2wA:
undetectable		 4azsA-4i2wA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		3 / 3 ARG A  60
ARG A  57
ILE A  25
 None
 0.87A 4b7qA-4i2wA:
undetectable		 4b7qA-4i2wA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		3 / 3 ARG A  60
ARG A  57
ILE A  25
 None
 0.79A 4b7qC-4i2wA:
undetectable		 4b7qC-4i2wA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		5 / 10 LEU A 322
ILE A 329
GLY A 328
GLY A 327
PHE A 318
 None
 1.05A 4fakA-4i2wA:
undetectable		 4fakA-4i2wA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		5 / 12 LEU A 574
LEU A 577
LEU A 580
ALA A 581
ALA A 593
 None
 1.02A 4fn9A-4i2wA:
undetectable		 4fn9A-4i2wA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		5 / 12 LEU A 170
LEU A 167
ASN A 166
LEU A 164
ALA A 163
 None
 1.19A 4fn9B-4i2wA:
undetectable		 4fn9B-4i2wA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		4 / 8 LEU A 421
SER A 469
VAL A 480
GLY A 481
 None
 0.99A 4klrB-4i2wA:
undetectable		 4klrB-4i2wA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		4 / 5 TYR A 413
LYS A 416
LEU A 356
GLU A 358
 None
 1.14A 4olaA-4i2wA:
undetectable		 4olaA-4i2wA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		4 / 5 TYR A 413
LYS A 416
LEU A 356
GLU A 358
 None
 1.28A 4olbA-4i2wA:
undetectable		 4olbA-4i2wA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		5 / 12 GLY A 257
LEU A 297
MET A 300
ILE A 195
PHE A 252
 None
 1.42A 4p6xI-4i2wA:
undetectable		 4p6xI-4i2wA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		3 / 3 GLU A 355
TYR A 549
GLU A 462
 None
 0.74A 4ryaA-4i2wA:
undetectable		 4ryaA-4i2wA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		4 / 5 TYR A 413
LYS A 416
LEU A 356
GLU A 358
 None
 1.34A 4z4dA-4i2wA:
undetectable		 4z4dA-4i2wA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		5 / 12 ILE A 216
MET A 228
ALA A 186
LEU A 187
HIS A 229
 None
 1.45A 4zo1X-4i2wA:
undetectable		 4zo1X-4i2wA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		4 / 7 LEU A 756
THR A 755
ILE A 711
LEU A 714
 None
 0.89A 5fxtA-4i2wA:
undetectable		 5fxtA-4i2wA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		3 / 3 ALA A 163
ASN A 166
LEU A 167
 None
 0.29A 5i1nB-4i2wA:
undetectable		 5i1nB-4i2wA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		4 / 5 LEU A 455
GLY A 458
ASP A 545
ILE A 546
 None
 0.74A 5ik1A-4i2wA:
undetectable		 5ik1A-4i2wA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		5 / 12 LEU A 753
LEU A 799
THR A 812
ILE A 770
ILE A 776
 None
 1.10A 5itzB-4i2wA:
undetectable		 5itzB-4i2wA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		5 / 12 LEU A 753
LEU A 799
THR A 812
ILE A 770
ILE A 776
 None
 1.17A 5nm5B-4i2wA:
undetectable		 5nm5B-4i2wA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		5 / 11 GLU A 523
GLY A 508
SER A 555
LEU A 554
ALA A 529
 None
 1.10A 5o96A-4i2wA:
undetectable
5o96B-4i2wA:
undetectable		 5o96A-4i2wA:
14.67
5o96B-4i2wA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		4 / 7 LEU A 373
GLN A 374
LEU A 347
PHE A 420
 None
 0.89A 5z85C-4i2wA:
2.3
5z85J-4i2wA:
undetectable		 5z85C-4i2wA:
14.04
5z85J-4i2wA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		4 / 7 LEU A 373
GLN A 374
LEU A 347
PHE A 420
 None
 0.86A 5zcoC-4i2wA:
2.3
5zcoJ-4i2wA:
undetectable		 5zcoC-4i2wA:
14.04
5zcoJ-4i2wA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		4 / 7 LEU A 373
GLN A 374
LEU A 347
PHE A 420
 None
 0.90A 5zcqC-4i2wA:
1.8
5zcqJ-4i2wA:
undetectable		 5zcqC-4i2wA:
14.04
5zcqJ-4i2wA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		4 / 7 LEU A 373
GLN A 374
LEU A 347
PHE A 420
 None
 0.90A 5zcqP-4i2wA:
2.3
5zcqW-4i2wA:
undetectable		 5zcqP-4i2wA:
14.04
5zcqW-4i2wA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		4 / 5 TYR A 413
LYS A 416
LEU A 356
GLU A 358
 None
 1.30A 6cbdA-4i2wA:
undetectable		 6cbdA-4i2wA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		5 / 9 LEU A 243
THR A 256
ILE A 209
VAL A 191
ILE A 195
 None
 1.17A 6ef6A-4i2wA:
undetectable		 6ef6A-4i2wA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 4i2w PROTEIN UNC-45
(Caenorhabditis
elegans) 		4 / 6 LEU A 693
THR A 696
CYH A 692
GLY A 708
 None
 0.89A 6gtqB-4i2wA:
undetectable
6gtqD-4i2wA:
undetectable		 6gtqB-4i2wA:
11.23
6gtqD-4i2wA:
4.39