SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i2y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A29_A_TFPA154_1
(CALMODULIN)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
5 / 10 LEU A 321
MET A 412
LEU A 419
GLU A 423
MET A 427
None
0.72A 1a29A-4i2yA:
18.2
1a29A-4i2yA:
65.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A29_A_TFPA154_1
(CALMODULIN)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
5 / 10 MET A 412
GLU A 417
LEU A 419
GLU A 423
MET A 427
None
0.63A 1a29A-4i2yA:
18.2
1a29A-4i2yA:
65.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CTR_A_TFPA153_1
(CALMODULIN)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
5 / 9 ILE A 403
LEU A 408
MET A 427
ALA A 431
VAL A 439
None
0.65A 1ctrA-4i2yA:
17.1
1ctrA-4i2yA:
65.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CTR_A_TFPA153_1
(CALMODULIN)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
5 / 9 LEU A 408
MET A 427
ALA A 431
VAL A 439
MET A 447
None
1.24A 1ctrA-4i2yA:
17.1
1ctrA-4i2yA:
65.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
8 / 11 PHE A 322
ILE A 330
LEU A 335
MET A 339
LEU A 342
MET A 354
VAL A 358
MET A 374
None
0.56A 1dtlA-4i2yA:
14.4
1dtlA-4i2yA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
6 / 11 PHE A 395
ILE A 403
LEU A 408
MET A 412
LEU A 415
MET A 427
None
0.64A 1dtlA-4i2yA:
14.4
1dtlA-4i2yA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
4 / 8 PRO A 233
GLU A 350
ASP A 353
ARG A 131
None
1.21A 1dtlA-4i2yA:
14.5
1dtlA-4i2yA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
4 / 8 ASP A 363
PHE A 366
THR A 365
ASP A 361
CA  A 501 (-3.0A)
None
CA  A 501 (-4.4A)
CA  A 501 (-2.9A)
0.92A 1ei6C-4i2yA:
undetectable
1ei6C-4i2yA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
4 / 5 LYS A  45
LEU A 321
GLU A 317
ALA A  46
None
1.12A 1eta1-4i2yA:
undetectable
1eta1-4i2yA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
4 / 5 LYS A  45
LEU A 321
GLU A 317
ALA A  46
None
1.10A 1eta2-4i2yA:
undetectable
1eta2-4i2yA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
4 / 6 LYS A  45
LEU A 321
GLU A 317
ALA A  46
None
1.14A 1etb1-4i2yA:
undetectable
1etb1-4i2yA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)
4i2y RGECO1
(Gallus
gallus;
Rattus
norvegicus;
Discosoma
sp.)
5 / 12 ILE A 262
TYR A  88
VAL A  92
ILE A  76
LEU A 218
None
None
None
NRQ  A 224 ( 4.7A)
None
1.21A 1fm4A-4i2yA:
undetectable
1fm4A-4i2yA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
4 / 6 PHE A 322
ILE A 355
ALA A  52
MET A 375
None
1.15A 1hk2A-4i2yA:
undetectable
1hk2A-4i2yA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)
4i2y RGECO1
(Gallus
gallus;
Rattus
norvegicus;
Discosoma
sp.)
3 / 3 ARG A  55
ARG A 304
ARG A  51
None
1.03A 1l7fA-4i2yA:
undetectable
1l7fA-4i2yA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)
4i2y RGECO1
(Gallus
gallus;
Rattus
norvegicus;
Discosoma
sp.)
3 / 3 ARG A  55
ARG A 304
ARG A  51
None
1.06A 1l7hA-4i2yA:
undetectable
1l7hA-4i2yA:
21.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LIN_A_TFPA154_1
(CALMODULIN)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
5 / 7 LEU A 321
MET A 412
LEU A 419
GLU A 423
MET A 427
None
0.84A 1linA-4i2yA:
18.4
1linA-4i2yA:
65.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LIN_A_TFPA154_1
(CALMODULIN)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
5 / 7 MET A 412
GLU A 417
LEU A 419
GLU A 423
MET A 427
None
0.68A 1linA-4i2yA:
18.4
1linA-4i2yA:
65.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LIN_A_TFPA155_1
(CALMODULIN)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
4 / 7 GLN A 311
GLU A 314
MET A 375
PHE A 395
None
0.79A 1linA-4i2yA:
18.4
1linA-4i2yA:
65.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LIN_A_TFPA155_1
(CALMODULIN)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
4 / 7 GLN A 311
MET A 375
PHE A 395
MET A 448
None
1.06A 1linA-4i2yA:
18.4
1linA-4i2yA:
65.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
6 / 12 PHE A 322
ILE A 330
LEU A 335
MET A 339
ILE A 355
MET A 374
None
1.06A 1lxfC-4i2yA:
8.0
1lxfC-4i2yA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
6 / 12 PHE A 322
ILE A 330
LEU A 335
MET A 339
MET A 354
ILE A 355
None
0.82A 1lxfC-4i2yA:
8.0
1lxfC-4i2yA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
9 / 12 PHE A 395
ILE A 403
LEU A 408
MET A 412
LEU A 415
MET A 427
ILE A 428
VAL A 439
MET A 448
None
1.06A 1lxfC-4i2yA:
8.0
1lxfC-4i2yA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
7 / 12 PHE A 395
ILE A 403
LEU A 408
MET A 412
VAL A 439
MET A 447
MET A 448
None
0.97A 1lxfC-4i2yA:
8.0
1lxfC-4i2yA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
4 / 5 PHE A 395
LEU A 415
PHE A 444
MET A 448
None
1.35A 1wrkB-4i2yA:
11.0
1wrkB-4i2yA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC206_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
5 / 9 MET A 339
LEU A 342
GLN A 344
GLU A 350
MET A 354
None
1.04A 1wrlC-4i2yA:
10.5
1wrlD-4i2yA:
10.9
1wrlC-4i2yA:
16.10
1wrlD-4i2yA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
4 / 5 PHE A 395
LEU A 415
PHE A 444
MET A 448
None
1.25A 1wrlC-4i2yA:
10.5
1wrlC-4i2yA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE210_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
5 / 9 MET A 339
LEU A 342
GLN A 344
GLU A 350
MET A 354
None
0.97A 1wrlE-4i2yA:
10.5
1wrlF-4i2yA:
10.8
1wrlE-4i2yA:
16.10
1wrlF-4i2yA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
4 / 7 PHE A 315
PHE A 322
PHE A 371
MET A 375
None
0.82A 1wrlE-4i2yA:
10.7
1wrlE-4i2yA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
5 / 12 MET A 354
ASN A 345
LEU A  56
ILE A  53
ALA A  52
None
1.00A 3a50A-4i2yA:
undetectable
3a50A-4i2yA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFA_B_SAMB406_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE N)
4i2y RGECO1
(Gallus
gallus;
Rattus
norvegicus;
Discosoma
sp.)
5 / 12 PHE A 322
MET A 354
PRO A  59
SER A  57
VAL A 338
None
1.20A 3rfaB-4i2yA:
undetectable
3rfaB-4i2yA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)
4i2y RGECO1
(Gallus
gallus;
Rattus
norvegicus;
Discosoma
sp.)
5 / 12 ILE A 262
TYR A  88
VAL A  92
ILE A  76
LEU A 218
None
None
None
NRQ  A 224 ( 4.7A)
None
1.24A 4a84A-4i2yA:
undetectable
4a84A-4i2yA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
4 / 6 PHE A 213
HIS A 263
VAL A  92
PHE A 286
None
1.04A 4a97E-4i2yA:
undetectable
4a97E-4i2yA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
3 / 3 LYS A  45
LEU A 321
ALA A  46
None
0.81A 4iizA-4i2yA:
undetectable
4iizA-4i2yA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)
4i2y RGECO1
(Gallus
gallus;
Rattus
norvegicus;
Discosoma
sp.)
4 / 4 ILE A 112
SER A  62
ASP A 115
ASP A 363
NRQ  A 224 ( 3.9A)
NRQ  A 224 ( 4.5A)
None
CA  A 501 (-3.0A)
1.31A 4krhB-4i2yA:
undetectable
4krhB-4i2yA:
23.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_A_TFPA203_1
(CALMODULIN)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
5 / 8 PHE A 322
ILE A 330
LEU A 335
MET A 354
MET A 374
None
0.72A 4rjdA-4i2yA:
11.9
4rjdA-4i2yA:
95.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_A_TFPA203_1
(CALMODULIN)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
5 / 8 PHE A 395
ILE A 403
LEU A 408
MET A 412
VAL A 439
None
0.41A 4rjdA-4i2yA:
11.9
4rjdA-4i2yA:
95.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_A_TFPA203_1
(CALMODULIN)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
6 / 8 PHE A 395
ILE A 403
LEU A 408
MET A 427
ALA A 431
VAL A 439
None
0.48A 4rjdA-4i2yA:
11.9
4rjdA-4i2yA:
95.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_A_TFPA203_1
(CALMODULIN)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
5 / 8 PHE A 395
MET A 427
ALA A 431
VAL A 439
MET A 447
None
0.95A 4rjdA-4i2yA:
11.9
4rjdA-4i2yA:
95.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_B_TFPB203_1
(CALMODULIN)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
5 / 7 PHE A 322
LEU A 335
MET A 354
MET A 374
MET A 375
None
0.72A 4rjdB-4i2yA:
12.2
4rjdB-4i2yA:
95.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_B_TFPB203_1
(CALMODULIN)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
5 / 7 PHE A 395
LEU A 408
MET A 412
ALA A 431
MET A 448
None
0.76A 4rjdB-4i2yA:
12.2
4rjdB-4i2yA:
95.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_B_TFPB203_1
(CALMODULIN)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
5 / 7 PHE A 395
LEU A 408
MET A 427
ALA A 431
MET A 448
None
0.67A 4rjdB-4i2yA:
12.2
4rjdB-4i2yA:
95.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_B_TFPB203_1
(CALMODULIN)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
5 / 7 PHE A 395
MET A 412
ALA A 431
MET A 447
MET A 448
None
1.08A 4rjdB-4i2yA:
12.2
4rjdB-4i2yA:
95.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_B_TFPB203_1
(CALMODULIN)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
5 / 7 PHE A 395
MET A 427
ALA A 431
MET A 447
MET A 448
None
1.04A 4rjdB-4i2yA:
12.2
4rjdB-4i2yA:
95.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)
4i2y RGECO1
(Discosoma
sp.;
Gallus
gallus;
Rattus
norvegicus)
4 / 6 TYR A 441
ARG A 393
ASP A 396
GLY A 401
None
None
CA  A 503 (-3.3A)
None
0.96A 5mraA-4i2yA:
undetectable
5mraB-4i2yA:
3.2
5mraA-4i2yA:
15.78
5mraB-4i2yA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)
4i2y RGECO1
(Gallus
gallus;
Rattus
norvegicus;
Discosoma
sp.)
5 / 10 LEU A 335
MET A 354
GLU A 357
VAL A 358
MET A 375
None
0.89A 5v02B-4i2yA:
undetectable
5v02R-4i2yA:
6.8
5v02B-4i2yA:
13.51
5v02R-4i2yA:
33.97