SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i34'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 4i34 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Escherichia
coli) 		5 / 12 GLY A 249
GLY A 248
LEU A 116
LEU A 287
LEU A  88
 None
 1.09A 1ya4B-4i34A:
2.3		 1ya4B-4i34A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 4i34 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Escherichia
coli) 		5 / 9 LEU A 254
ILE A 118
GLY A 119
SER A 259
LEU A 286
 None
 1.15A 2qmmA-4i34A:
undetectable		 2qmmA-4i34A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 4i34 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Escherichia
coli) 		4 / 7 ARG A 100
VAL A 310
LEU A 110
ILE A 115
 None
 0.70A 3gp0A-4i34A:
undetectable		 3gp0A-4i34A:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 4i34 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Escherichia
coli) 		4 / 8 ILE A 305
LEU A 300
PHE A 251
GLY A 249
 None
 0.91A 3selX-4i34A:
undetectable		 3selX-4i34A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 4i34 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Escherichia
coli) 		4 / 7 ILE A 358
SER A 401
LEU A 348
VAL A 397
 None
 0.79A 3ua5B-4i34A:
undetectable		 3ua5B-4i34A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4i34 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Escherichia
coli) 		3 / 3 LEU A 254
ILE A 258
ARG A 261
 None
 0.70A 4mk4B-4i34A:
undetectable		 4mk4B-4i34A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA301_1
(CHITOSANASE)		 4i34 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Escherichia
coli) 		4 / 4 ASP A 255
GLY A 119
PRO A 120
GLN A  81
 None
 1.25A 4oltA-4i34A:
undetectable		 4oltA-4i34A:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 4i34 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Escherichia
coli) 		4 / 8 THR A 141
LEU A 165
ILE A 162
LEU A 166
 None
 0.95A 5g48A-4i34A:
undetectable		 5g48A-4i34A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4i34 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Escherichia
coli) 		5 / 11 THR A 313
ALA A 312
ALA A  84
GLY A 249
GLY A 248
 None
 0.94A 6hwdK-4i34A:
undetectable
6hwdL-4i34A:
undetectable		 6hwdK-4i34A:
13.30
6hwdL-4i34A:
18.70