SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i3f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 4i3f SERINE HYDROLASE
CCSP0084
(Cycloclasticus
sp.
P1) 		4 / 5 LEU A 215
LEU A 241
SER A 104
GLY A 131
 None
None
CL  A 302 (-3.0A)
None
 0.96A 1a4lC-4i3fA:
undetectable		 1a4lC-4i3fA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 4i3f SERINE HYDROLASE
CCSP0084
(Cycloclasticus
sp.
P1) 		5 / 10 GLY A 106
GLN A 261
ASN A  41
THR A 110
GLY A 107
 None
None
CL  A 301 (-3.3A)
None
None
 0.99A 1kvlA-4i3fA:
undetectable		 1kvlA-4i3fA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 4i3f SERINE HYDROLASE
CCSP0084
(Cycloclasticus
sp.
P1) 		4 / 5 GLU A 214
THR A 110
LEU A 114
LEU A 111
 None
 1.06A 1u18B-4i3fA:
undetectable		 1u18B-4i3fA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4i3f SERINE HYDROLASE
CCSP0084
(Cycloclasticus
sp.
P1) 		5 / 12 LEU A 126
ILE A 100
LEU A  29
GLY A 106
GLY A 107
 None
 0.91A 1uakA-4i3fA:
undetectable		 1uakA-4i3fA:
26.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4i3f SERINE HYDROLASE
CCSP0084
(Cycloclasticus
sp.
P1) 		5 / 11 GLY A  31
SER A  32
PHE A 134
TRP A 144
HIS A 258
 CL  A 301 (-3.7A)
CL  A 302 (-3.1A)
None
None
None
 0.66A 1ukbA-4i3fA:
41.2		 1ukbA-4i3fA:
34.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4i3f SERINE HYDROLASE
CCSP0084
(Cycloclasticus
sp.
P1) 		4 / 7 PHE A 193
LEU A 158
PHE A  63
SER A  40
 None
 1.11A 1wrlE-4i3fA:
undetectable		 1wrlE-4i3fA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 4i3f SERINE HYDROLASE
CCSP0084
(Cycloclasticus
sp.
P1) 		5 / 11 ILE A  26
PHE A 276
THR A 110
VAL A 101
THR A  24
 None
 1.23A 2w3aA-4i3fA:
undetectable		 2w3aA-4i3fA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 4i3f SERINE HYDROLASE
CCSP0084
(Cycloclasticus
sp.
P1) 		3 / 3 SER A  32
HIS A  68
ASP A  88
 CL  A 302 (-3.1A)
None
None
 0.63A 2wa2B-4i3fA:
undetectable		 2wa2B-4i3fA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 4i3f SERINE HYDROLASE
CCSP0084
(Cycloclasticus
sp.
P1) 		3 / 3 GLU A 214
ASP A 212
TYR A 240
 None
 0.55A 2yvlB-4i3fA:
2.9		 2yvlB-4i3fA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 4i3f SERINE HYDROLASE
CCSP0084
(Cycloclasticus
sp.
P1) 		5 / 11 PHE A 197
GLY A  74
ALA A 207
GLY A 200
ALA A 227
 None
 1.20A 4l6v1-4i3fA:
undetectable
4l6v6-4i3fA:
undetectable		 4l6v1-4i3fA:
16.56
4l6v6-4i3fA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4i3f SERINE HYDROLASE
CCSP0084
(Cycloclasticus
sp.
P1) 		5 / 7 PHE A  63
ILE A  60
PHE A 193
GLY A  33
LEU A 140
 None
None
None
CL  A 301 (-4.0A)
None
 1.20A 4zdzA-4i3fA:
undetectable		 4zdzA-4i3fA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4i3f SERINE HYDROLASE
CCSP0084
(Cycloclasticus
sp.
P1) 		5 / 9 PHE A  63
ILE A  60
PHE A 193
GLY A  33
LEU A 140
 None
None
None
CL  A 301 (-4.0A)
None
 1.17A 4ze0A-4i3fA:
undetectable		 4ze0A-4i3fA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4i3f SERINE HYDROLASE
CCSP0084
(Cycloclasticus
sp.
P1) 		4 / 7 PHE A  63
PHE A 193
GLY A  33
LEU A 140
 None
None
CL  A 301 (-4.0A)
None
 0.92A 4ze3A-4i3fA:
undetectable		 4ze3A-4i3fA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4i3f SERINE HYDROLASE
CCSP0084
(Cycloclasticus
sp.
P1) 		5 / 8 PHE A  63
ILE A  60
PHE A 193
GLY A  33
LEU A 140
 None
None
None
CL  A 301 (-4.0A)
None
 1.23A 5esfA-4i3fA:
undetectable		 5esfA-4i3fA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4i3f SERINE HYDROLASE
CCSP0084
(Cycloclasticus
sp.
P1) 		5 / 12 PHE A  63
ILE A  60
PHE A 193
GLY A  33
LEU A 140
 None
None
None
CL  A 301 (-4.0A)
None
 1.19A 5esgA-4i3fA:
undetectable		 5esgA-4i3fA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4i3f SERINE HYDROLASE
CCSP0084
(Cycloclasticus
sp.
P1) 		5 / 12 PHE A  63
ILE A  60
PHE A 193
GLY A  33
LEU A 140
 None
None
None
CL  A 301 (-4.0A)
None
 1.20A 5eshA-4i3fA:
undetectable		 5eshA-4i3fA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4i3f SERINE HYDROLASE
CCSP0084
(Cycloclasticus
sp.
P1) 		5 / 11 LEU A  27
PRO A  58
GLY A 106
LEU A  90
ARG A 116
 None
 1.11A 5o96A-4i3fA:
undetectable
5o96B-4i3fA:
undetectable		 5o96A-4i3fA:
19.69
5o96B-4i3fA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 4i3f SERINE HYDROLASE
CCSP0084
(Cycloclasticus
sp.
P1) 		3 / 3 TRP A  42
MET A  39
ASN A  37
 None
 1.27A 5uc1B-4i3fA:
undetectable		 5uc1B-4i3fA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 4i3f SERINE HYDROLASE
CCSP0084
(Cycloclasticus
sp.
P1) 		3 / 3 TRP A  42
MET A  39
ASN A  37
 None
 1.27A 5uc1A-4i3fA:
undetectable		 5uc1A-4i3fA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4i3f SERINE HYDROLASE
CCSP0084
(Cycloclasticus
sp.
P1) 		5 / 12 LEU A 126
ILE A 100
LEU A  29
GLY A 106
GLY A 107
 None
 0.97A 5wyqB-4i3fA:
2.1		 5wyqB-4i3fA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 4i3f SERINE HYDROLASE
CCSP0084
(Cycloclasticus
sp.
P1) 		5 / 12 GLY A 131
VAL A 130
THR A 201
GLY A 200
GLY A 199
 None
 1.22A 6brdB-4i3fA:
undetectable		 6brdB-4i3fA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 4i3f SERINE HYDROLASE
CCSP0084
(Cycloclasticus
sp.
P1) 		4 / 7 SER A  32
SER A 104
GLY A 107
LEU A 140
 CL  A 302 (-3.1A)
CL  A 302 (-3.0A)
None
None
 0.94A 6btxA-4i3fA:
undetectable		 6btxA-4i3fA:
23.11