SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i3g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 11 TYR A 573
THR A 590
GLY A 440
THR A 554
VAL A 546
 None
SO4  A 904 (-4.5A)
None
None
None
 1.21A 1akdA-4i3gA:
undetectable		 1akdA-4i3gA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 12 ILE A 448
PRO A 449
ASN A 452
LEU A 476
THR A 590
 None
None
None
None
SO4  A 904 (-4.5A)
 0.76A 1dhfA-4i3gA:
undetectable		 1dhfA-4i3gA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 12 GLU A 203
ASP A 581
ARG A 162
TYR A 683
ALA A 211
 None
None
BGC  A 901 (-3.0A)
None
None
 1.14A 1kijB-4i3gA:
undetectable		 1kijB-4i3gA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		4 / 5 LEU A 190
TRP A 269
LEU A 345
GLN A 144
 None
 1.46A 1p93D-4i3gA:
undetectable		 1p93D-4i3gA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		4 / 8 VAL A 478
ASP A 481
HIS A 525
LEU A 499
 None
 1.14A 1pk2A-4i3gA:
undetectable		 1pk2A-4i3gA:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 11 TYR A 573
THR A 590
GLY A 440
THR A 554
VAL A 546
 None
SO4  A 904 (-4.5A)
None
None
None
 1.20A 2a1nA-4i3gA:
undetectable		 2a1nA-4i3gA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 12 ALA A 749
VAL A 731
GLY A 821
VAL A 782
VAL A 784
 None
 0.81A 2ieoB-4i3gA:
undetectable		 2ieoB-4i3gA:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		4 / 5 ALA A 141
ALA A 361
GLN A 108
VAL A 413
 None
None
SO4  A 902 (-3.5A)
None
 0.89A 2nyrB-4i3gA:
7.3		 2nyrB-4i3gA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 12 ILE A 448
PRO A 449
ASN A 452
LEU A 476
THR A 590
 None
None
None
None
SO4  A 904 (-4.5A)
 0.73A 2w3bB-4i3gA:
undetectable		 2w3bB-4i3gA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 12 ILE A 448
PRO A 449
ASN A 452
LEU A 476
THR A 590
 None
None
None
None
SO4  A 904 (-4.5A)
 0.75A 2w3mA-4i3gA:
undetectable		 2w3mA-4i3gA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 10 GLU A 215
PHE A 223
ALA A 194
PHE A 197
LEU A 256
 None
 1.35A 3a3yA-4i3gA:
2.4		 3a3yA-4i3gA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 12 LEU A 315
GLY A 312
TRP A 269
ASP A 288
LEU A  94
 None
 0.98A 3eeoA-4i3gA:
undetectable		 3eeoA-4i3gA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		4 / 6 LEU A 585
GLU A 662
ASN A 663
SER A 614
 None
None
SO4  A 906 (-3.8A)
None
 1.32A 3i9jB-4i3gA:
undetectable		 3i9jB-4i3gA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 12 GLY A 132
ALA A 128
ALA A 188
ILE A 185
GLN A 186
 None
 0.98A 3id6C-4i3gA:
undetectable		 3id6C-4i3gA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 12 ASN A 242
GLY A 160
ILE A 155
ASN A 154
GLU A 169
 None
 1.45A 3jb2A-4i3gA:
undetectable		 3jb2A-4i3gA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		3 / 3 GLU A  93
ASP A 145
ASP A  76
 None
 0.65A 3jb2A-4i3gA:
undetectable		 3jb2A-4i3gA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 9 TYR A 711
GLY A 387
ALA A 389
THR A 567
ILE A 606
 None
None
SO4  A 907 ( 4.7A)
None
None
 1.30A 3jusB-4i3gA:
undetectable		 3jusB-4i3gA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_2
(GENOME POLYPROTEIN)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		4 / 4 GLN A 748
PHE A 123
TYR A 691
LEU A 375
 None
 1.46A 3keeC-4i3gA:
undetectable		 3keeC-4i3gA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 10 TYR A 573
THR A 590
GLY A 440
THR A 554
VAL A 546
 None
SO4  A 904 (-4.5A)
None
None
None
 1.29A 3lxiA-4i3gA:
undetectable		 3lxiA-4i3gA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		4 / 7 LEU A 541
ARG A 489
THR A 491
ALA A 490
 None
 1.23A 3mbgA-4i3gA:
undetectable
3mbgB-4i3gA:
undetectable		 3mbgA-4i3gA:
9.77
3mbgB-4i3gA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 12 THR A 824
ALA A 823
VAL A 827
ALA A 753
GLY A 752
 None
 0.73A 3mg0Y-4i3gA:
undetectable
3mg0Z-4i3gA:
undetectable		 3mg0Y-4i3gA:
14.13
3mg0Z-4i3gA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 11 THR A 590
GLY A 589
PRO A 588
THR A 443
ASP A 575
 SO4  A 904 (-4.5A)
None
None
None
None
 1.15A 3t8nD-4i3gA:
undetectable
3t8nF-4i3gA:
undetectable		 3t8nD-4i3gA:
11.22
3t8nF-4i3gA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		3 / 3 SER A 501
GLY A 500
GLN A 498
 None
 0.35A 3v4tH-4i3gA:
undetectable		 3v4tH-4i3gA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 11 LEU A 627
GLY A 652
PHE A 705
VAL A 648
GLY A 372
 None
 1.11A 3zosA-4i3gA:
undetectable
3zosB-4i3gA:
undetectable		 3zosA-4i3gA:
17.33
3zosB-4i3gA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 11 LEU A 627
LEU A 654
GLY A 652
VAL A 648
GLY A 372
 None
 1.04A 3zosA-4i3gA:
undetectable
3zosB-4i3gA:
undetectable		 3zosA-4i3gA:
17.33
3zosB-4i3gA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		4 / 5 ASP A  63
THR A  61
LEU A  62
LYS A 316
 None
 1.33A 4a3pA-4i3gA:
0.8		 4a3pA-4i3gA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 12 LEU A 543
LEU A 541
ILE A 504
ILE A 529
PHE A 532
 None
 1.09A 4a7aB-4i3gA:
undetectable		 4a7aB-4i3gA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		4 / 7 ILE A 155
GLU A 169
VAL A 746
PHE A 705
 None
 1.08A 4a97H-4i3gA:
undetectable		 4a97H-4i3gA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		4 / 5 HIS A 412
GLY A 511
TYR A 510
GLU A 578
 None
None
None
BGC  A 901 (-3.2A)
 1.27A 4ae1B-4i3gA:
undetectable		 4ae1B-4i3gA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 9 TYR A 573
THR A 590
GLY A 440
THR A 554
VAL A 546
 None
SO4  A 904 (-4.5A)
None
None
None
 1.28A 4c9kA-4i3gA:
undetectable		 4c9kA-4i3gA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 9 TYR A 573
THR A 590
GLY A 440
THR A 554
VAL A 546
 None
SO4  A 904 (-4.5A)
None
None
None
 1.29A 4c9kB-4i3gA:
undetectable		 4c9kB-4i3gA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV7_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		3 / 3 LYS A 247
PRO A 248
LYS A 285
 None
 1.49A 4dv7L-4i3gA:
undetectable		 4dv7L-4i3gA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 10 VAL A 721
LEU A 729
VAL A 731
LEU A 751
VAL A 786
 None
 0.89A 4e3hA-4i3gA:
undetectable		 4e3hA-4i3gA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		3 / 3 PHE A 237
ASP A 288
ARG A 261
 None
 0.80A 4eahF-4i3gA:
1.3		 4eahF-4i3gA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		3 / 3 PHE A 237
ASP A 288
ARG A 261
 None
 0.80A 4eahG-4i3gA:
1.4		 4eahG-4i3gA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 10 MET A 534
PHE A 532
ALA A 506
GLY A 531
MET A 238
 None
None
None
None
BGC  A 901 (-4.1A)
 1.13A 4fe1A-4i3gA:
undetectable
4fe1J-4i3gA:
undetectable		 4fe1A-4i3gA:
22.96
4fe1J-4i3gA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		4 / 6 ASN A 201
GLU A 222
GLN A 181
MET A 135
 None
 1.04A 4g0vB-4i3gA:
2.8		 4g0vB-4i3gA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		4 / 6 GLY A 409
ASN A 101
GLU A 165
MET A 534
 None
 1.22A 4g0vB-4i3gA:
2.8		 4g0vB-4i3gA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		6 / 11 ILE A 283
THR A 280
ALA A 314
LEU A 315
THR A 317
VAL A 319
 None
 1.48A 4g1bB-4i3gA:
4.0		 4g1bB-4i3gA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		4 / 5 THR A 111
LEU A 113
THR A 166
MET A 151
 None
 1.44A 4mbsB-4i3gA:
undetectable		 4mbsB-4i3gA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 12 VAL A 513
GLY A 576
ASP A 575
THR A 443
THR A 577
 None
 1.40A 4mubA-4i3gA:
2.2		 4mubA-4i3gA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		4 / 8 MET A 534
PHE A 532
ALA A 506
GLY A 531
 None
 0.65A 4xk8a-4i3gA:
undetectable		 4xk8a-4i3gA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 7 ILE A 529
PHE A 457
ARG A 489
THR A 491
LEU A 539
 None
 1.34A 5b1bN-4i3gA:
undetectable
5b1bW-4i3gA:
undetectable		 5b1bN-4i3gA:
21.21
5b1bW-4i3gA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 7 ILE A 529
PHE A 457
ARG A 489
THR A 491
LEU A 539
 None
 1.35A 5b3sN-4i3gA:
undetectable
5b3sW-4i3gA:
undetectable		 5b3sN-4i3gA:
21.21
5b3sW-4i3gA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 9 TYR A 573
THR A 590
GLY A 440
THR A 554
VAL A 546
 None
SO4  A 904 (-4.5A)
None
None
None
 1.21A 5cp4A-4i3gA:
undetectable		 5cp4A-4i3gA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 12 PHE A 237
GLY A  81
MET A 291
GLY A 149
LEU A 105
 None
None
BGC  A 901 ( 4.0A)
None
None
 1.05A 5gwxA-4i3gA:
2.8		 5gwxA-4i3gA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 9 ALA A 568
THR A 567
ALA A 565
ALA A 394
ALA A 601
 None
 1.10A 5l5zK-4i3gA:
undetectable
5l5zL-4i3gA:
undetectable		 5l5zK-4i3gA:
14.37
5l5zL-4i3gA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 9 ALA A 568
THR A 567
ALA A 565
ALA A 394
ALA A 601
 None
 1.10A 5l5zY-4i3gA:
undetectable
5l5zZ-4i3gA:
undetectable		 5l5zY-4i3gA:
14.37
5l5zZ-4i3gA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M6G_A_SORA711_0
(BETA-GLUCOSIDASE)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		7 / 12 ASP A  98
ARG A 162
LYS A 195
HIS A 196
MET A 238
MET A 291
GLU A 578
 BGC  A 901 (-2.9A)
BGC  A 901 (-3.0A)
BGC  A 901 (-2.8A)
BGC  A 901 (-4.0A)
BGC  A 901 (-4.1A)
BGC  A 901 ( 4.0A)
BGC  A 901 (-3.2A)
 0.41A 5m6gA-4i3gA:
32.2		 5m6gA-4i3gA:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 12 ILE A 283
PRO A 278
GLY A 286
ASP A 253
GLY A 251
 None
 1.05A 5nnaA-4i3gA:
undetectable		 5nnaA-4i3gA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 12 ILE A 283
PRO A 278
GLY A 286
ASP A 253
GLY A 251
 None
 1.07A 5nnaB-4i3gA:
undetectable		 5nnaB-4i3gA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 12 ILE A 283
PRO A 278
GLY A 286
ASP A 253
GLY A 251
 None
 1.06A 5nnaC-4i3gA:
1.7		 5nnaC-4i3gA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 12 ILE A 283
PRO A 278
GLY A 286
ASP A 253
GLY A 251
 None
 1.09A 5nnaD-4i3gA:
undetectable		 5nnaD-4i3gA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		4 / 7 ARG A 104
ASP A  98
LEU A 148
SER A 272
 BGC  A 901 ( 4.9A)
BGC  A 901 (-2.9A)
BGC  A 901 ( 4.1A)
None
 1.02A 5uxcA-4i3gA:
undetectable		 5uxcA-4i3gA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		4 / 5 THR A 611
ASN A 610
TRP A 630
LEU A 654
 None
 1.46A 5vkqA-4i3gA:
0.0
5vkqB-4i3gA:
0.2		 5vkqA-4i3gA:
20.48
5vkqB-4i3gA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		4 / 5 THR A 611
ASN A 610
TRP A 630
LEU A 654
 None
 1.48A 5vkqB-4i3gA:
0.0
5vkqC-4i3gA:
0.0		 5vkqB-4i3gA:
20.48
5vkqC-4i3gA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		4 / 5 THR A 611
ASN A 610
TRP A 630
LEU A 654
 None
 1.48A 5vkqC-4i3gA:
0.0
5vkqD-4i3gA:
0.0		 5vkqC-4i3gA:
20.48
5vkqD-4i3gA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 12 ALA A 120
GLY A 612
ASP A 125
ARG A 176
TYR A 769
 None
None
SO4  A 905 (-3.7A)
SO4  A 905 (-4.1A)
None
 1.32A 5zvgA-4i3gA:
3.2		 5zvgA-4i3gA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 12 ALA A 120
GLY A 612
ASP A 125
ARG A 176
TYR A 769
 None
None
SO4  A 905 (-3.7A)
SO4  A 905 (-4.1A)
None
 1.30A 5zvgB-4i3gA:
undetectable		 5zvgB-4i3gA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		4 / 7 TRP A 545
THR A 547
PRO A 548
PRO A 479
 None
 1.43A 6a4iB-4i3gA:
undetectable		 6a4iB-4i3gA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 12 ILE A 182
LEU A 218
PHE A 197
PHE A 237
LEU A 255
 None
 1.42A 6a93A-4i3gA:
undetectable		 6a93A-4i3gA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		4 / 8 TYR A 131
GLY A 184
ILE A 182
ASP A 125
 None
None
None
SO4  A 905 (-3.7A)
 0.94A 6ag0A-4i3gA:
5.6		 6ag0A-4i3gA:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		5 / 12 LEU A 453
LEU A 476
GLY A 544
GLY A 445
PRO A 479
 None
 1.12A 6ce2B-4i3gA:
undetectable		 6ce2B-4i3gA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4i3g BETA-GLUCOSIDASE
(Streptomyces
venezuelae) 		4 / 7 THR A 166
ARG A 692
HIS A 688
ASP A 170
 None
 1.32A 6mn4E-4i3gA:
undetectable		 6mn4E-4i3gA:
15.36