SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i3h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA
(Streptococcus
pneumoniae) 		4 / 5 ARG A 601
ALA A 538
LYS A 500
GLU A 428
 None
 1.04A 1e7cA-4i3hA:
2.5		 1e7cA-4i3hA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA
(Streptococcus
pneumoniae) 		4 / 8 TYR A1229
GLY A1210
LEU A1482
VAL A1238
 None
 1.10A 1gsfA-4i3hA:
undetectable		 1gsfA-4i3hA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA
(Streptococcus
pneumoniae) 		4 / 8 TYR A1229
GLY A1210
LEU A1482
VAL A1238
 None
 1.10A 1gsfB-4i3hA:
undetectable		 1gsfB-4i3hA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA
(Streptococcus
pneumoniae) 		4 / 8 TYR A1229
GLY A1210
LEU A1482
VAL A1238
 None
 1.10A 1gsfD-4i3hA:
undetectable		 1gsfD-4i3hA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA
(Streptococcus
pneumoniae) 		5 / 11 LEU A 328
GLY A 284
GLU A 287
GLY A 283
PRO A 333
 None
 1.12A 1p91A-4i3hA:
undetectable		 1p91A-4i3hA:
12.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA
(Streptococcus
pneumoniae) 		4 / 7 MET A 526
ALA A 485
PHE A 522
ASN A 497
 None
 1.39A 1t9wA-4i3hA:
4.2		 1t9wA-4i3hA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA
(Streptococcus
pneumoniae) 		3 / 3 ILE A1225
ASP A1212
PHE A1213
 None
 0.57A 1uwjB-4i3hA:
0.2		 1uwjB-4i3hA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA
(Streptococcus
pneumoniae) 		3 / 3 THR A1168
PRO A1180
TYR A1261
 None
 0.96A 2dxrA-4i3hA:
undetectable		 2dxrA-4i3hA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA
(Streptococcus
pneumoniae) 		5 / 12 LEU A  57
VAL A  53
VAL A 332
SER A 349
PHE A 339
 None
 1.49A 2y00A-4i3hA:
3.1		 2y00A-4i3hA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA
(Streptococcus
pneumoniae) 		5 / 12 LEU A  57
VAL A  53
VAL A 332
SER A 349
PHE A 339
 None
 1.49A 2y00B-4i3hA:
undetectable		 2y00B-4i3hA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA
(Streptococcus
pneumoniae) 		3 / 3 TYR A1046
GLU A1151
THR A1148
 None
 0.95A 2y7hB-4i3hA:
2.2		 2y7hB-4i3hA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA
(Streptococcus
pneumoniae) 		5 / 11 ILE A1178
GLY A1341
HIS A1181
PRO A1179
ILE A1342
 None
 1.38A 2y7kA-4i3hA:
undetectable		 2y7kA-4i3hA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA
(Streptococcus
pneumoniae) 		5 / 10 ILE A1178
GLY A1341
HIS A1181
PRO A1179
ILE A1342
 None
 1.47A 2y7pA-4i3hA:
undetectable		 2y7pA-4i3hA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA
(Streptococcus
pneumoniae) 		5 / 10 ILE A1178
GLY A1341
HIS A1181
PRO A1179
ILE A1342
 None
 1.35A 2y7wB-4i3hA:
undetectable		 2y7wB-4i3hA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA
(Streptococcus
pneumoniae) 		4 / 8 ASP A1333
GLY A1341
ILE A1342
PRO A1179
 None
 0.83A 3el9A-4i3hA:
undetectable		 3el9A-4i3hA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA
(Streptococcus
pneumoniae) 		3 / 3 ARG A1353
ILE A1126
THR A1054
 None
 0.68A 3ia4D-4i3hA:
undetectable		 3ia4D-4i3hA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA
(Streptococcus
pneumoniae) 		4 / 6 ARG A1478
PHE A1213
TYR A1261
PRO A1211
 None
 1.35A 3jqaA-4i3hA:
undetectable		 3jqaA-4i3hA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA
(Streptococcus
pneumoniae) 		4 / 6 ARG A1478
PHE A1213
TYR A1261
PRO A1211
 None
 1.27A 3jqaC-4i3hA:
undetectable		 3jqaC-4i3hA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA
(Streptococcus
pneumoniae) 		4 / 6 ARG A1478
PHE A1213
TYR A1261
PRO A1211
 None
 1.30A 3jqaD-4i3hA:
undetectable		 3jqaD-4i3hA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA
(Streptococcus
pneumoniae) 		5 / 12 VAL A 126
LEU A 130
LEU A 102
PHE A 183
GLY A  34
 None
 1.17A 3kk6B-4i3hA:
undetectable		 3kk6B-4i3hA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA
(Streptococcus
pneumoniae) 		3 / 3 GLY A1103
THR A1119
ASN A1105
 None
 0.65A 3v4tD-4i3hA:
undetectable		 3v4tD-4i3hA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFB_A_T27A607_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H,
EXORIBONUCLEA P66 RT)		 4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA
(Streptococcus
pneumoniae) 		5 / 12 PRO A1214
VAL A1236
TYR A1261
TYR A1325
PHE A1327
 None
 1.47A 4kfbA-4i3hA:
3.8		 4kfbA-4i3hA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA
(Streptococcus
pneumoniae) 		5 / 9 VAL A1343
ILE A1342
LEU A1163
ILE A1201
GLY A1210
 None
 1.09A 4kukA-4i3hA:
undetectable		 4kukA-4i3hA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA
(Streptococcus
pneumoniae) 		5 / 8 GLU A1290
GLU A1301
GLN A1253
ILE A1244
LEU A1302
 None
 1.12A 4mj8A-4i3hA:
undetectable		 4mj8A-4i3hA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA
(Streptococcus
pneumoniae) 		4 / 6 SER A1079
GLY A 434
ASP A 435
GLY A 457
 None
 0.68A 5cdnC-4i3hA:
55.6
5cdnD-4i3hA:
22.1		 5cdnC-4i3hA:
20.56
5cdnD-4i3hA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA
(Streptococcus
pneumoniae) 		4 / 6 SER A1079
GLY A 434
ASP A 435
GLY A 457
 None
 0.67A 5cdnT-4i3hA:
56.1
5cdnU-4i3hA:
22.0		 5cdnT-4i3hA:
20.56
5cdnU-4i3hA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA
(Streptococcus
pneumoniae) 		3 / 3 THR A1168
THR A1176
PHE A1327
 None
 0.85A 5cxvA-4i3hA:
undetectable		 5cxvA-4i3hA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA
(Streptococcus
pneumoniae) 		4 / 5 HIS A 534
ILE A 502
ILE A 501
TYR A 430
 None
 1.20A 5dnuA-4i3hA:
2.5		 5dnuA-4i3hA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA
(Streptococcus
pneumoniae) 		5 / 12 ASP A1177
ILE A1178
PRO A1211
ARG A1095
GLY A1166
 None
 1.20A 5k7uA-4i3hA:
undetectable		 5k7uA-4i3hA:
11.31