SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i3r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 4i3r HEAVY CHAIN OF
VRC-PG04 FAB
LIGHT CHAIN OF
VRC-PG04 FAB
(Homo
sapiens) 		6 / 12 TYR L  36
GLN L  89
PHE L  98
VAL H  37
ALA H  93
TRP H 103
 None
 0.66A 1h8sA-4i3rL:
19.0		 1h8sA-4i3rL:
35.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 4i3r LIGHT CHAIN OF
VRC-PG04 FAB
(Homo
sapiens) 		4 / 7 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.82A 1ictD-4i3rL:
2.6		 1ictD-4i3rL:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 4i3r HEAVY CHAIN OF
VRC-PG04 FAB
(Homo
sapiens) 		5 / 12 ASP H  62
ILE H  82
ILE H 109
TYR H  90
ALA H  88
 None
 1.12A 1kijB-4i3rH:
undetectable		 1kijB-4i3rH:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 4i3r HEAVY CHAIN OF
VRC-PG04 FAB
(Homo
sapiens) 		4 / 4 ALA H  40
ARG H  38
GLN H  43
GLU H  46
 None
 0.91A 1lqtB-4i3rH:
undetectable		 1lqtB-4i3rH:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 4i3r HEAVY CHAIN OF
VRC-PG04 FAB
(Homo
sapiens) 		4 / 4 ALA H  40
ARG H  38
GLN H  43
GLU H  46
 None
 0.93A 1lquB-4i3rH:
undetectable		 1lquB-4i3rH:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4i3r LIGHT CHAIN OF
VRC-PG04 FAB
(Homo
sapiens) 		4 / 5 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.91A 2aojA-4i3rL:
undetectable		 2aojA-4i3rL:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4i3r HEAVY CHAIN OF
VRC-PG04 FAB
(Homo
sapiens) 		4 / 6 LEU H 189
GLY H 190
ALA H 125
PRO H 126
 None
 0.51A 3huoA-4i3rH:
undetectable		 3huoA-4i3rH:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 4i3r HEAVY CHAIN OF
VRC-PG04 FAB
(Homo
sapiens) 		5 / 12 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.41A 3nyaA-4i3rH:
undetectable		 3nyaA-4i3rH:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_B_CUB301_0
(E7)		 4i3r LIGHT CHAIN OF
VRC-PG04 FAB
(Homo
sapiens) 		4 / 5 ALA L  50
HIS L  32
GLN L  66
TYR L  71
 None
 1.50A 4gboB-4i3rL:
3.0		 4gboB-4i3rL:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4i3r HEAVY CHAIN OF
VRC-PG04 FAB
(Homo
sapiens) 		5 / 11 ALA H 137
THR H 183
GLY H 134
GLY H 133
SER H 132
 None
 1.10A 4qvwK-4i3rH:
undetectable
4qvwL-4i3rH:
undetectable		 4qvwK-4i3rH:
24.90
4qvwL-4i3rH:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4i3r HEAVY CHAIN OF
VRC-PG04 FAB
(Homo
sapiens) 		5 / 11 ALA H 137
THR H 183
GLY H 134
GLY H 133
SER H 132
 None
 1.10A 4qvwY-4i3rH:
undetectable
4qvwZ-4i3rH:
undetectable		 4qvwY-4i3rH:
24.90
4qvwZ-4i3rH:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 4i3r HEAVY CHAIN OF
VRC-PG04 FAB
(Homo
sapiens) 		5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 1.06A 4qvyH-4i3rH:
undetectable		 4qvyH-4i3rH:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4i3r HEAVY CHAIN OF
VRC-PG04 FAB
(Homo
sapiens) 		5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 1.06A 4qvyV-4i3rH:
undetectable
4qvyW-4i3rH:
undetectable		 4qvyV-4i3rH:
20.25
4qvyW-4i3rH:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4i3r HEAVY CHAIN OF
VRC-PG04 FAB
(Homo
sapiens) 		5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 1.00A 5bxnH-4i3rH:
undetectable
5bxnI-4i3rH:
undetectable		 5bxnH-4i3rH:
21.80
5bxnI-4i3rH:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 4i3r HEAVY CHAIN OF
VRC-PG04 FAB
(Homo
sapiens) 		5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 1.04A 5d0xV-4i3rH:
undetectable		 5d0xV-4i3rH:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4i3r HEAVY CHAIN OF
VRC-PG04 FAB
(Homo
sapiens) 		5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 1.02A 5l5fH-4i3rH:
undetectable
5l5fI-4i3rH:
undetectable		 5l5fH-4i3rH:
20.25
5l5fI-4i3rH:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4i3r HEAVY CHAIN OF
VRC-PG04 FAB
(Homo
sapiens) 		5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 1.02A 5l5fV-4i3rH:
undetectable
5l5fW-4i3rH:
undetectable		 5l5fV-4i3rH:
20.25
5l5fW-4i3rH:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4i3r HEAVY CHAIN OF
VRC-PG04 FAB
(Homo
sapiens) 		4 / 4 GLY H  49
ARG H  64
ASN H  57
LEU H  69
 None
 1.07A 6b58A-4i3rH:
undetectable		 6b58A-4i3rH:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 4i3r HEAVY CHAIN OF
VRC-PG04 FAB
(Homo
sapiens) 		5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 1.08A 6hwdV-4i3rH:
undetectable		 6hwdV-4i3rH:
21.23