SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i4i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 4i4i 6-PHOSPHOFRUCTOKINAS
E
(Geobacillus
stearothermophil
us) 		4 / 5 LEU A 263
LEU A 267
LEU A 274
GLY A 285
 None
 1.03A 1a4lC-4i4iA:
undetectable		 1a4lC-4i4iA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4i4i 6-PHOSPHOFRUCTOKINAS
E
(Geobacillus
stearothermophil
us) 		4 / 7 THR A 238
VAL A 201
THR A 163
ILE A 218
 None
 0.85A 1gtnC-4i4iA:
undetectable
1gtnD-4i4iA:
undetectable		 1gtnC-4i4iA:
14.52
1gtnD-4i4iA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 4i4i 6-PHOSPHOFRUCTOKINAS
E
(Geobacillus
stearothermophil
us) 		5 / 10 ARG A 266
GLY A 138
ASP A 129
GLY A 101
ILE A 100
 None
 0.96A 1sh9B-4i4iA:
undetectable		 1sh9B-4i4iA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 4i4i 6-PHOSPHOFRUCTOKINAS
E
(Geobacillus
stearothermophil
us) 		5 / 10 ILE A 191
VAL A 224
ALA A 221
ILE A 218
VAL A 165
 None
 0.98A 2nnjA-4i4iA:
undetectable		 2nnjA-4i4iA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4i4i 6-PHOSPHOFRUCTOKINAS
E
(Geobacillus
stearothermophil
us) 		6 / 12 ILE A 130
ALA A 142
GLY A 138
GLY A 124
ASN A 144
ASN A 128
 None
 1.42A 2okcB-4i4iA:
undetectable		 2okcB-4i4iA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1437_1
(ORF12)		 4i4i 6-PHOSPHOFRUCTOKINAS
E
(Geobacillus
stearothermophil
us) 		5 / 10 SER A 105
SER A   9
GLY A 108
ALA A 109
PHE A  76
 None
 1.48A 2xh9B-4i4iA:
undetectable		 2xh9B-4i4iA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 4i4i 6-PHOSPHOFRUCTOKINAS
E
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 138
ASP A 127
GLY A 101
ILE A 100
ALA A 264
 None
 0.82A 3n3iA-4i4iA:
undetectable		 3n3iA-4i4iA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 4i4i 6-PHOSPHOFRUCTOKINAS
E
(Geobacillus
stearothermophil
us) 		5 / 9 ILE A  45
LEU A 112
PHE A 117
ARG A   3
GLY A  96
 None
 1.00A 3nxuB-4i4iA:
undetectable		 3nxuB-4i4iA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 4i4i 6-PHOSPHOFRUCTOKINAS
E
(Geobacillus
stearothermophil
us) 		5 / 9 ASP A  12
GLY A 102
ILE A 130
ILE A 176
ILE A 126
 None
 1.10A 3s56B-4i4iA:
undetectable		 3s56B-4i4iA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 4i4i 6-PHOSPHOFRUCTOKINAS
E
(Geobacillus
stearothermophil
us) 		5 / 9 ILE A 286
LEU A 267
ILE A 130
MET A  16
GLY A  15
 None
 1.33A 3sj4X-4i4iA:
undetectable		 3sj4X-4i4iA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4i4i 6-PHOSPHOFRUCTOKINAS
E
(Geobacillus
stearothermophil
us) 		4 / 5 TYR A 106
VAL A  99
SER A 105
GLY A 124
 None
 1.12A 3v4tA-4i4iA:
undetectable
3v4tD-4i4iA:
undetectable		 3v4tA-4i4iA:
22.33
3v4tD-4i4iA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4i4i 6-PHOSPHOFRUCTOKINAS
E
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 137
ASP A 260
THR A 145
ILE A 126
GLU A 222
 None
 1.30A 4i41A-4i4iA:
undetectable		 4i41A-4i4iA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4i4i 6-PHOSPHOFRUCTOKINAS
E
(Geobacillus
stearothermophil
us) 		4 / 5 ASN A  17
GLY A  64
ASP A 129
ASP A  12
 None
 0.90A 4n48A-4i4iA:
undetectable		 4n48A-4i4iA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4i4i 6-PHOSPHOFRUCTOKINAS
E
(Geobacillus
stearothermophil
us) 		4 / 5 ASN A  17
GLY A  64
ASP A 129
ASP A  12
 None
 0.95A 4n48B-4i4iA:
undetectable		 4n48B-4i4iA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4i4i 6-PHOSPHOFRUCTOKINAS
E
(Geobacillus
stearothermophil
us) 		4 / 4 ASN A  17
GLY A  64
ASP A 129
ASP A  12
 None
 0.94A 4n49A-4i4iA:
undetectable		 4n49A-4i4iA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4i4i 6-PHOSPHOFRUCTOKINAS
E
(Geobacillus
stearothermophil
us) 		3 / 3 ASN A 288
ASP A 134
ASP A 307
 None
 0.82A 4obwD-4i4iA:
undetectable		 4obwD-4i4iA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4i4i 6-PHOSPHOFRUCTOKINAS
E
(Geobacillus
stearothermophil
us) 		5 / 9 ALA A  19
ALA A  18
GLY A 101
GLY A 124
ASP A 260
 None
 1.11A 4qwuK-4i4iA:
undetectable
4qwuL-4i4iA:
undetectable		 4qwuK-4i4iA:
21.12
4qwuL-4i4iA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4i4i 6-PHOSPHOFRUCTOKINAS
E
(Geobacillus
stearothermophil
us) 		5 / 9 ALA A  19
ALA A  18
GLY A 101
GLY A 124
ASP A 260
 None
 1.15A 4qwuY-4i4iA:
undetectable
4qwuZ-4i4iA:
undetectable		 4qwuY-4i4iA:
21.12
4qwuZ-4i4iA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4i4i 6-PHOSPHOFRUCTOKINAS
E
(Geobacillus
stearothermophil
us) 		5 / 12 THR A   8
GLY A  11
GLY A  10
ALA A 142
THR A 145
 None
 1.16A 4uckB-4i4iA:
undetectable		 4uckB-4i4iA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4i4i 6-PHOSPHOFRUCTOKINAS
E
(Geobacillus
stearothermophil
us) 		4 / 4 GLY A 268
VAL A 284
PHE A 135
ILE A 286
 None
 0.91A 4xv2B-4i4iA:
undetectable		 4xv2B-4i4iA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 4i4i 6-PHOSPHOFRUCTOKINAS
E
(Geobacillus
stearothermophil
us) 		6 / 12 LEU A 275
VAL A  23
ILE A  20
ALA A  18
VAL A   6
ILE A   4
 None
 1.32A 5j2tC-4i4iA:
undetectable		 5j2tC-4i4iA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 4i4i 6-PHOSPHOFRUCTOKINAS
E
(Geobacillus
stearothermophil
us) 		6 / 12 VAL A  23
ILE A  20
ALA A  18
VAL A   6
GLY A   5
ILE A   4
 None
 0.97A 5j2tC-4i4iA:
undetectable		 5j2tC-4i4iA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 4i4i 6-PHOSPHOFRUCTOKINAS
E
(Geobacillus
stearothermophil
us) 		3 / 3 HIS A 209
LYS A 206
PHE A 240
 None
 1.45A 5klaA-4i4iA:
undetectable		 5klaA-4i4iA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 4i4i 6-PHOSPHOFRUCTOKINAS
E
(Geobacillus
stearothermophil
us) 		4 / 7 ILE A  45
LEU A 112
PHE A 117
ARG A   3
 None
 0.99A 5vc0A-4i4iA:
undetectable		 5vc0A-4i4iA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 4i4i 6-PHOSPHOFRUCTOKINAS
E
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 268
ILE A 137
TYR A 106
CYH A 119
GLY A 101
 None
 1.05A 6bp4B-4i4iA:
undetectable		 6bp4B-4i4iA:
19.88