SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i4j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 4i4j ACP-POLYENE
THIOESTERASE
(Streptomyces
globisporus) 		3 / 3 ASP A  77
PHE A  17
ASN A  25
 None
 0.68A 1sg9B-4i4jA:
undetectable		 1sg9B-4i4jA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 4i4j ACP-POLYENE
THIOESTERASE
(Streptomyces
globisporus) 		3 / 3 THR A 126
THR A 128
PRO A 124
 None
 0.84A 209dC-4i4jA:
undetectable		 209dC-4i4jA:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4i4j ACP-POLYENE
THIOESTERASE
(Streptomyces
globisporus) 		4 / 7 TYR A  31
THR A  20
LEU A  79
VAL A  15
 None
 0.97A 2cppA-4i4jA:
undetectable		 2cppA-4i4jA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 4i4j ACP-POLYENE
THIOESTERASE
(Streptomyces
globisporus) 		3 / 3 THR A 128
PRO A 124
THR A 126
 None
 0.83A 316dC-4i4jA:
undetectable		 316dC-4i4jA:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 4i4j ACP-POLYENE
THIOESTERASE
(Streptomyces
globisporus) 		5 / 10 LEU A  60
GLU A  40
LEU A  43
LEU A 141
PHE A  95
 None
 1.21A 3jw5B-4i4jA:
undetectable		 3jw5B-4i4jA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4A_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4i4j ACP-POLYENE
THIOESTERASE
(Streptomyces
globisporus) 		4 / 8 TYR A  31
THR A  20
LEU A  79
VAL A  15
 None
 0.96A 4l4aA-4i4jA:
undetectable		 4l4aA-4i4jA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4i4j ACP-POLYENE
THIOESTERASE
(Streptomyces
globisporus) 		4 / 8 TYR A  31
THR A  20
LEU A  79
VAL A  15
 None
 0.95A 4l4dA-4i4jA:
undetectable		 4l4dA-4i4jA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 4i4j ACP-POLYENE
THIOESTERASE
(Streptomyces
globisporus) 		4 / 4 VAL A  26
THR A  20
GLU A  19
GLU A  18
 None
 1.26A 4l78A-4i4jA:
undetectable		 4l78A-4i4jA:
9.40