SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i4n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		5 / 11 GLY A 190
THR A  80
HIS A  76
ILE A 154
ALA A  58
 None
 1.13A 1gtnM-4i4nA:
undetectable
1gtnN-4i4nA:
undetectable		 1gtnM-4i4nA:
12.10
1gtnN-4i4nA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		5 / 11 LEU A 237
PHE A 242
GLY A 190
VAL A  56
LEU A 195
 None
 1.05A 1mx1A-4i4nA:
2.3		 1mx1A-4i4nA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_T_TRPT81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		5 / 10 GLY A 190
THR A  80
HIS A  76
ILE A 154
ALA A  58
 None
 1.09A 1utdT-4i4nA:
undetectable
1utdU-4i4nA:
undetectable		 1utdT-4i4nA:
12.10
1utdU-4i4nA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		6 / 12 ALA A 192
GLY A 156
GLY A 157
LEU A 161
LEU A 164
MET A 162
 None
 1.18A 1ya4A-4i4nA:
2.4		 1ya4A-4i4nA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		3 / 3 LEU A  54
LEU A 260
MET A 259
 None
 0.47A 2itzA-4i4nA:
undetectable		 2itzA-4i4nA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		5 / 9 ALA A 275
GLY A 268
LEU A  82
PRO A 155
ILE A 185
 None
 1.04A 3em4B-4i4nA:
undetectable		 3em4B-4i4nA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		5 / 12 ILE A 139
ALA A 142
LEU A 133
VAL A 173
THR A 141
 None
 1.11A 3ix9A-4i4nA:
undetectable		 3ix9A-4i4nA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		5 / 12 ILE A 139
ALA A 142
LEU A 133
VAL A 173
THR A 141
 None
 1.12A 3ix9B-4i4nA:
undetectable		 3ix9B-4i4nA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		5 / 9 PHE A  94
PHE A 183
ILE A 150
ALA A 275
VAL A 283
 None
 1.19A 3me6C-4i4nA:
undetectable		 3me6C-4i4nA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		5 / 9 PHE A  94
PHE A 183
ILE A 150
ALA A 275
VAL A 283
 None
 1.22A 3me6D-4i4nA:
undetectable		 3me6D-4i4nA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		5 / 12 ALA A 142
SER A  93
TYR A 149
VAL A 173
ALA A  97
 None
 1.22A 3qxvE-4i4nA:
undetectable		 3qxvE-4i4nA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		5 / 9 PHE A 203
PHE A 194
ILE A 184
THR A 261
PHE A 242
 None
 1.33A 3t3rB-4i4nA:
undetectable		 3t3rB-4i4nA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		4 / 4 ASN A  75
ALA A  58
GLY A  57
THR A  98
 None
 1.26A 4bboC-4i4nA:
undetectable		 4bboC-4i4nA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		3 / 3 ASP A  13
ARG A  61
ASP A  17
 None
 0.90A 4fp9C-4i4nA:
undetectable		 4fp9C-4i4nA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		3 / 3 ASP A  13
ARG A  61
ASP A  17
 None
 0.84A 4fp9F-4i4nA:
undetectable		 4fp9F-4i4nA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		4 / 7 TYR A  25
PHE A  30
SER A  23
SER A 221
 None
 1.19A 4lv9A-4i4nA:
undetectable
4lv9B-4i4nA:
undetectable		 4lv9A-4i4nA:
20.75
4lv9B-4i4nA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZP0_A_DXCA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		5 / 10 TYR A 224
MET A  65
LEU A  63
LEU A 229
GLY A 156
 None
 1.44A 4zp0A-4i4nA:
undetectable		 4zp0A-4i4nA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		5 / 9 SER A 186
ALA A 210
GLY A 156
GLY A 157
ASP A 216
 None
 1.03A 5d0xK-4i4nA:
undetectable
5d0xL-4i4nA:
undetectable		 5d0xK-4i4nA:
21.05
5d0xL-4i4nA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		5 / 9 SER A 186
ALA A 210
GLY A 156
GLY A 157
ASP A 216
 None
 1.02A 5d0xY-4i4nA:
undetectable
5d0xZ-4i4nA:
undetectable		 5d0xY-4i4nA:
21.05
5d0xZ-4i4nA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		5 / 10 ALA A  58
GLY A 190
THR A  80
HIS A  76
ILE A 154
 None
 1.10A 5eeuF-4i4nA:
undetectable
5eeuG-4i4nA:
undetectable		 5eeuF-4i4nA:
12.10
5eeuG-4i4nA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		5 / 12 ALA A  58
GLY A 190
THR A  80
HIS A  76
ILE A 154
 None
 1.13A 5eeuI-4i4nA:
undetectable
5eeuJ-4i4nA:
undetectable		 5eeuI-4i4nA:
12.10
5eeuJ-4i4nA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		5 / 10 GLY A 190
THR A  80
HIS A  76
ILE A 154
ALA A  58
 None
 1.11A 5eeuO-4i4nA:
undetectable
5eeuP-4i4nA:
undetectable		 5eeuO-4i4nA:
12.10
5eeuP-4i4nA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		5 / 10 GLY A 190
THR A  80
HIS A  76
ILE A 154
ALA A  58
 None
 1.10A 5eeuQ-4i4nA:
undetectable
5eeuR-4i4nA:
undetectable		 5eeuQ-4i4nA:
12.10
5eeuR-4i4nA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		5 / 10 ALA A  58
GLY A 190
THR A  80
HIS A  76
ILE A 154
 None
 1.10A 5eevF-4i4nA:
undetectable
5eevG-4i4nA:
undetectable		 5eevF-4i4nA:
12.10
5eevG-4i4nA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		5 / 12 ALA A  58
GLY A 190
THR A  80
HIS A  76
ILE A 154
 None
 1.13A 5eevI-4i4nA:
undetectable
5eevJ-4i4nA:
undetectable		 5eevI-4i4nA:
12.10
5eevJ-4i4nA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		5 / 10 GLY A 190
THR A  80
HIS A  76
ILE A 154
ALA A  58
 None
 1.10A 5eevQ-4i4nA:
undetectable
5eevR-4i4nA:
undetectable		 5eevQ-4i4nA:
12.10
5eevR-4i4nA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		5 / 10 ALA A  58
GLY A 190
THR A  80
HIS A  76
ILE A 154
 None
 1.10A 5eewF-4i4nA:
undetectable
5eewG-4i4nA:
undetectable		 5eewF-4i4nA:
12.10
5eewG-4i4nA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		5 / 12 ALA A  58
GLY A 190
THR A  80
HIS A  76
ILE A 154
 None
 1.13A 5eewI-4i4nA:
undetectable
5eewJ-4i4nA:
undetectable		 5eewI-4i4nA:
12.10
5eewJ-4i4nA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		5 / 10 GLY A 190
THR A  80
HIS A  76
ILE A 154
ALA A  58
 None
 1.10A 5eewQ-4i4nA:
undetectable
5eewR-4i4nA:
undetectable		 5eewQ-4i4nA:
12.10
5eewR-4i4nA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		5 / 10 ALA A  58
GLY A 190
THR A  80
HIS A  76
ILE A 154
 None
 1.11A 5eexF-4i4nA:
undetectable
5eexG-4i4nA:
undetectable		 5eexF-4i4nA:
12.10
5eexG-4i4nA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		5 / 10 ALA A  58
GLY A 190
THR A  80
HIS A  76
ILE A 154
 None
 1.11A 5eeyF-4i4nA:
undetectable
5eeyG-4i4nA:
undetectable		 5eeyF-4i4nA:
12.10
5eeyG-4i4nA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		5 / 10 ALA A  58
GLY A 190
THR A  80
HIS A  76
ILE A 154
 None
 1.11A 5eezF-4i4nA:
undetectable
5eezG-4i4nA:
undetectable		 5eezF-4i4nA:
12.10
5eezG-4i4nA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		5 / 10 ALA A  58
GLY A 190
THR A  80
HIS A  76
ILE A 154
 None
 1.11A 5ef0F-4i4nA:
undetectable
5ef0G-4i4nA:
undetectable		 5ef0F-4i4nA:
12.10
5ef0G-4i4nA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		5 / 10 ALA A  58
GLY A 190
THR A  80
HIS A  76
ILE A 154
 None
 1.11A 5ef1F-4i4nA:
undetectable
5ef1G-4i4nA:
undetectable		 5ef1F-4i4nA:
12.10
5ef1G-4i4nA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		5 / 10 ALA A  58
GLY A 190
THR A  80
HIS A  76
ILE A 154
 None
 1.12A 5ef2F-4i4nA:
undetectable
5ef2G-4i4nA:
undetectable		 5ef2F-4i4nA:
12.10
5ef2G-4i4nA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		5 / 10 ALA A  58
GLY A 190
THR A  80
HIS A  76
ILE A 154
 None
 1.12A 5ef3F-4i4nA:
undetectable
5ef3G-4i4nA:
undetectable		 5ef3F-4i4nA:
12.10
5ef3G-4i4nA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		5 / 12 GLY A 234
PRO A 191
ALA A 192
PRO A 212
GLU A 214
 None
 1.30A 5x6yC-4i4nA:
undetectable		 5x6yC-4i4nA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 4i4n INTRACELLULAR
PROTEASE/AMIDASE
(Vibrio
cholerae) 		4 / 7 VAL A 104
LEU A 266
PHE A 153
LEU A 187
 None
 0.94A 6aycA-4i4nA:
undetectable		 6aycA-4i4nA:
17.76