SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i4q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 4i4q BEL-BETA TREFOIL
(Boletus
edulis) 		4 / 5 LEU A 118
ILE A  24
SER A  26
ARG A  27
 None
None
None
GOL  A 201 (-4.0A)
 0.91A 2byoA-4i4qA:
undetectable		 2byoA-4i4qA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4i4q BEL-BETA TREFOIL
(Boletus
edulis) 		5 / 11 SER A 120
ALA A  17
ALA A 125
GLY A 124
THR A 123
 None
 1.05A 2f16H-4i4qA:
undetectable
2f16I-4i4qA:
undetectable		 2f16H-4i4qA:
24.41
2f16I-4i4qA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4i4q BEL-BETA TREFOIL
(Boletus
edulis) 		5 / 11 SER A 120
ALA A  17
ALA A 125
GLY A 124
THR A 123
 None
 1.06A 2f16V-4i4qA:
undetectable
2f16W-4i4qA:
undetectable		 2f16V-4i4qA:
24.41
2f16W-4i4qA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 4i4q BEL-BETA TREFOIL
(Boletus
edulis) 		3 / 3 ASN A  91
TYR A 110
SER A  73
 None
 0.85A 2gvcB-4i4qA:
undetectable		 2gvcB-4i4qA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 4i4q BEL-BETA TREFOIL
(Boletus
edulis) 		3 / 3 ASN A  91
TYR A 110
SER A  73
 None
 0.88A 2gvcE-4i4qA:
undetectable		 2gvcE-4i4qA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W13_A_ACTA1208_0
(ZINC
METALLOPROTEINASE
BAP1)		 4i4q BEL-BETA TREFOIL
(Boletus
edulis) 		4 / 4 THR A  28
ARG A  27
GLU A  29
ASN A  30
 None
GOL  A 201 (-4.0A)
None
None
 1.11A 2w13A-4i4qA:
undetectable		 2w13A-4i4qA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 4i4q BEL-BETA TREFOIL
(Boletus
edulis) 		5 / 12 ALA A  17
GLY A  21
LEU A 140
ARG A 108
SER A 120
 None
 1.07A 3bxoA-4i4qA:
undetectable		 3bxoA-4i4qA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF201_1
(PROTEIN S100-A4)		 4i4q BEL-BETA TREFOIL
(Boletus
edulis) 		4 / 5 PHE A  47
PHE A  13
PHE A  95
PHE A  97
 None
 1.31A 3ko0F-4i4qA:
undetectable
3ko0G-4i4qA:
undetectable		 3ko0F-4i4qA:
19.44
3ko0G-4i4qA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF201_1
(PROTEIN S100-A4)		 4i4q BEL-BETA TREFOIL
(Boletus
edulis) 		4 / 5 PHE A  95
PHE A  97
PHE A  47
PHE A  13
 None
 1.41A 3ko0F-4i4qA:
undetectable
3ko0G-4i4qA:
undetectable		 3ko0F-4i4qA:
19.44
3ko0G-4i4qA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4i4q BEL-BETA TREFOIL
(Boletus
edulis) 		5 / 11 SER A 120
ALA A  17
ALA A 125
GLY A 124
THR A 123
 None
 1.09A 3mg0V-4i4qA:
undetectable
3mg0W-4i4qA:
undetectable		 3mg0V-4i4qA:
24.41
3mg0W-4i4qA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 4i4q BEL-BETA TREFOIL
(Boletus
edulis) 		3 / 3 ARG A 121
ASP A 138
TYR A 131
 GOL  A 203 (-3.6A)
GOL  A 203 (-3.0A)
GOL  A 203 ( 3.6A)
 0.87A 4yo9B-4i4qA:
undetectable		 4yo9B-4i4qA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 4i4q BEL-BETA TREFOIL
(Boletus
edulis) 		3 / 3 ARG A  27
PRO A  32
TYR A  37
 GOL  A 201 (-4.0A)
None
GOL  A 201 ( 4.0A)
 1.03A 5tzoB-4i4qA:
undetectable		 5tzoB-4i4qA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4i4q BEL-BETA TREFOIL
(Boletus
edulis) 		5 / 12 SER A 120
ALA A  17
ALA A 125
GLY A 124
THR A 123
 None
 1.05A 6hwdH-4i4qA:
undetectable
6hwdI-4i4qA:
undetectable		 6hwdH-4i4qA:
21.28
6hwdI-4i4qA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 4i4q BEL-BETA TREFOIL
(Boletus
edulis) 		5 / 11 SER A 120
ALA A  17
ALA A 125
GLY A 124
THR A 123
 None
 1.05A 6hwdV-4i4qA:
undetectable		 6hwdV-4i4qA:
21.28