SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i4s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 4i4s BEL BETA-TREFOIL
(Boletus
edulis) 		4 / 5 LEU A 118
ILE A  24
SER A  26
ARG A  27
 None
None
None
GOL  A 203 (-3.9A)
 0.95A 2byoA-4i4sA:
undetectable		 2byoA-4i4sA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 4i4s BEL BETA-TREFOIL
(Boletus
edulis) 		5 / 10 ILE A  24
LEU A  71
ASN A  93
ASN A  67
ILE A  84
 None
None
LAT  A 201 (-3.1A)
None
LAT  A 201 (-3.9A)
 1.22A 2nnhB-4i4sA:
undetectable		 2nnhB-4i4sA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W13_A_ACTA1208_0
(ZINC
METALLOPROTEINASE
BAP1)		 4i4s BEL BETA-TREFOIL
(Boletus
edulis) 		4 / 4 THR A  28
ARG A  27
GLU A  29
ASN A  30
 None
GOL  A 203 (-3.9A)
None
None
 1.06A 2w13A-4i4sA:
undetectable		 2w13A-4i4sA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 4i4s BEL BETA-TREFOIL
(Boletus
edulis) 		5 / 12 ALA A  17
GLY A  21
LEU A 140
ARG A 108
SER A 120
 None
 1.05A 3bxoA-4i4sA:
undetectable		 3bxoA-4i4sA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF201_1
(PROTEIN S100-A4)		 4i4s BEL BETA-TREFOIL
(Boletus
edulis) 		4 / 5 PHE A  47
PHE A  13
PHE A  95
PHE A  97
 None
 1.32A 3ko0F-4i4sA:
undetectable
3ko0G-4i4sA:
undetectable		 3ko0F-4i4sA:
22.30
3ko0G-4i4sA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF201_1
(PROTEIN S100-A4)		 4i4s BEL BETA-TREFOIL
(Boletus
edulis) 		4 / 5 PHE A  95
PHE A  97
PHE A  47
PHE A  13
 None
 1.42A 3ko0F-4i4sA:
undetectable
3ko0G-4i4sA:
undetectable		 3ko0F-4i4sA:
22.30
3ko0G-4i4sA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 4i4s BEL BETA-TREFOIL
(Boletus
edulis) 		3 / 3 ARG A  27
ASP A  44
TYR A  37
 GOL  A 203 (-3.9A)
GOL  A 203 (-3.0A)
GOL  A 203 (-3.6A)
 0.90A 4yo9B-4i4sA:
undetectable		 4yo9B-4i4sA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 4i4s BEL BETA-TREFOIL
(Boletus
edulis) 		3 / 3 ARG A 121
ASP A 138
TYR A 131
 GOL  A 202 (-3.8A)
GOL  A 202 (-3.0A)
GOL  A 202 (-3.6A)
 0.87A 4yo9B-4i4sA:
undetectable		 4yo9B-4i4sA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 4i4s BEL BETA-TREFOIL
(Boletus
edulis) 		3 / 3 ARG A  27
PRO A  32
TYR A  37
 GOL  A 203 (-3.9A)
None
GOL  A 203 (-3.6A)
 0.97A 5tzoB-4i4sA:
undetectable		 5tzoB-4i4sA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 4i4s BEL BETA-TREFOIL
(Boletus
edulis) 		3 / 3 ARG A 121
PRO A 126
TYR A 131
 GOL  A 202 (-3.8A)
None
GOL  A 202 (-3.6A)
 0.97A 5tzoB-4i4sA:
undetectable		 5tzoB-4i4sA:
23.16