SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i4z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 4i4z NAPHTHOATE SYNTHASE
(Synechocystis
sp.
PCC
6803) 		5 / 11 ALA A 136
THR A 134
LEU A  42
GLY A  62
ALA A  33
 None
None
None
None
2NE  A 301 ( 3.7A)
 1.13A 1b02A-4i4zA:
undetectable		 1b02A-4i4zA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4i4z NAPHTHOATE SYNTHASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 ALA A 136
PHE A 142
ALA A 120
ALA A 114
 None
 0.89A 4du2A-4i4zA:
undetectable		 4du2A-4i4zA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4i4z NAPHTHOATE SYNTHASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 ALA A 136
PHE A 142
ALA A 120
ALA A 114
 None
 0.79A 4du2B-4i4zA:
undetectable		 4du2B-4i4zA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4i4z NAPHTHOATE SYNTHASE
(Synechocystis
sp.
PCC
6803) 		4 / 5 TYR A  87
GLN A  79
GLY A  77
SER A  75
 2NE  A 301 (-4.3A)
2NE  A 301 (-3.7A)
2NE  A 301 (-3.7A)
2NE  A 301 (-3.1A)
 1.28A 4fu8A-4i4zA:
undetectable		 4fu8A-4i4zA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4i4z NAPHTHOATE SYNTHASE
(Synechocystis
sp.
PCC
6803) 		5 / 11 LEU A 222
PHE A 226
ASP A 229
ALA A 225
ILE A 164
 None
 1.25A 4uuuA-4i4zA:
undetectable
4uuuB-4i4zA:
undetectable		 4uuuA-4i4zA:
20.92
4uuuB-4i4zA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4i4z NAPHTHOATE SYNTHASE
(Synechocystis
sp.
PCC
6803) 		5 / 11 LEU A 222
PHE A 226
ASP A 229
ALA A 225
ILE A 164
 None
 1.22A 4uuuB-4i4zA:
undetectable		 4uuuB-4i4zA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 4i4z NAPHTHOATE SYNTHASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 GLU A 252
THR A 244
TYR A 247
PHE A 268
 None
 1.19A 5lrbA-4i4zA:
2.9		 5lrbA-4i4zA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA717_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4i4z NAPHTHOATE SYNTHASE
(Synechocystis
sp.
PCC
6803) 		4 / 5 SER A  80
ASP A  78
ARG A  27
LYS A  30
 2NE  A 301 ( 4.9A)
2NE  A 301 (-4.0A)
None
2NE  A 301 (-4.5A)
 1.33A 6dwdA-4i4zA:
undetectable		 6dwdA-4i4zA:
18.76