SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i5s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 4i5s PUTATIVE HISTIDINE
KINASE COVS
VICK-LIKE PROTEIN
(Streptococcus
mutans) 		3 / 3 ASP A 324
THR A 329
GLU A 253
 None
 0.65A 1pj7A-4i5sA:
undetectable		 1pj7A-4i5sA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDK_A_C2FA1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 4i5s PUTATIVE HISTIDINE
KINASE COVS
VICK-LIKE PROTEIN
(Streptococcus
mutans) 		5 / 11 THR A 285
MET A 353
SER A 318
LEU A 431
HIS A 411
 None
 1.28A 2idkA-4i5sA:
undetectable
2idkB-4i5sA:
undetectable
2idkC-4i5sA:
undetectable
2idkD-4i5sA:
1.4		 2idkA-4i5sA:
20.13
2idkB-4i5sA:
20.13
2idkC-4i5sA:
20.13
2idkD-4i5sA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4i5s PUTATIVE HISTIDINE
KINASE COVS
VICK-LIKE PROTEIN
(Streptococcus
mutans) 		4 / 7 ILE A 321
LEU A 360
MET A 328
THR A 329
 None
 1.08A 2zxwN-4i5sA:
undetectable
2zxwW-4i5sA:
2.3		 2zxwN-4i5sA:
20.74
2zxwW-4i5sA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4i5s PUTATIVE HISTIDINE
KINASE COVS
VICK-LIKE PROTEIN
(Streptococcus
mutans) 		4 / 6 ILE A 321
LEU A 360
MET A 328
THR A 329
 None
 1.15A 3wg7A-4i5sA:
undetectable
3wg7J-4i5sA:
2.3		 3wg7A-4i5sA:
20.74
3wg7J-4i5sA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 4i5s VICK-LIKE PROTEIN
PUTATIVE HISTIDINE
KINASE COVS
(Streptococcus
mutans) 		4 / 8 LEU A 378
ILE A 379
GLY A 370
ILE A 371
 None
 0.86A 3wxoA-4i5sA:
undetectable		 3wxoA-4i5sA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 4i5s VICK-LIKE PROTEIN
PUTATIVE HISTIDINE
KINASE COVS
(Streptococcus
mutans) 		3 / 3 SER A 275
ASP A 263
GLN A 330
 None
 0.93A 4oltA-4i5sA:
undetectable
4oltB-4i5sA:
undetectable		 4oltA-4i5sA:
18.50
4oltB-4i5sA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB302_1
(CHITOSANASE)		 4i5s VICK-LIKE PROTEIN
PUTATIVE HISTIDINE
KINASE COVS
(Streptococcus
mutans) 		4 / 5 GLU A 253
ILE A 291
THR A 329
TYR A 229
 None
 1.47A 4qwpB-4i5sA:
undetectable		 4qwpB-4i5sA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 4i5s VICK-LIKE PROTEIN
PUTATIVE HISTIDINE
KINASE COVS
(Streptococcus
mutans) 		3 / 3 GLN A 330
SER A 275
ASP A 263
 None
 0.93A 4qwpA-4i5sA:
undetectable
4qwpB-4i5sA:
undetectable		 4qwpA-4i5sA:
18.10
4qwpB-4i5sA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 4i5s PUTATIVE HISTIDINE
KINASE COVS
VICK-LIKE PROTEIN
(Streptococcus
mutans) 		5 / 12 ILE A 139
VAL A 161
LEU A 108
PHE A 178
THR A 157
 None
 1.21A 5bykA-4i5sA:
undetectable		 5bykA-4i5sA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 4i5s VICK-LIKE PROTEIN
PUTATIVE HISTIDINE
KINASE COVS
(Streptococcus
mutans) 		4 / 6 ILE A 176
GLY A 190
ASN A 181
ILE A 139
 None
 0.78A 5j4nB-4i5sA:
undetectable		 5j4nB-4i5sA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 4i5s PUTATIVE HISTIDINE
KINASE COVS
VICK-LIKE PROTEIN
(Streptococcus
mutans) 		5 / 12 ILE A 176
LEU A 143
ILE A 116
LEU A 191
THR A 110
 None
 1.26A 5tiwA-4i5sA:
undetectable		 5tiwA-4i5sA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 4i5s PUTATIVE HISTIDINE
KINASE COVS
VICK-LIKE PROTEIN
(Streptococcus
mutans) 		5 / 12 ILE A 176
ASP A 145
LEU A 143
LEU A 191
THR A 110
 None
 1.32A 5tiwB-4i5sA:
undetectable		 5tiwB-4i5sA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4i5s PUTATIVE HISTIDINE
KINASE COVS
VICK-LIKE PROTEIN
(Streptococcus
mutans) 		4 / 7 ILE A 321
LEU A 360
MET A 328
THR A 329
 None
 0.83A 5xdqA-4i5sA:
undetectable
5xdqJ-4i5sA:
undetectable		 5xdqA-4i5sA:
20.74
5xdqJ-4i5sA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4i5s PUTATIVE HISTIDINE
KINASE COVS
VICK-LIKE PROTEIN
(Streptococcus
mutans) 		4 / 7 ILE A 321
LEU A 360
MET A 328
THR A 329
 None
 0.83A 5xdqN-4i5sA:
undetectable
5xdqW-4i5sA:
2.1		 5xdqN-4i5sA:
20.74
5xdqW-4i5sA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4i5s PUTATIVE HISTIDINE
KINASE COVS
VICK-LIKE PROTEIN
(Streptococcus
mutans) 		5 / 11 ALA A 417
SER A 425
ILE A 340
ASN A 338
ILE A 311
 None
 1.16A 5y80A-4i5sA:
undetectable		 5y80A-4i5sA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA609_0
(ALPHA-AMYLASE)		 4i5s PUTATIVE HISTIDINE
KINASE COVS
VICK-LIKE PROTEIN
(Streptococcus
mutans) 		4 / 7 LYS A 388
GLY A 398
ASP A 366
TYR A 342
 None
 1.45A 6ag0A-4i5sA:
undetectable		 6ag0A-4i5sA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC609_0
(ALPHA-AMYLASE)		 4i5s PUTATIVE HISTIDINE
KINASE COVS
VICK-LIKE PROTEIN
(Streptococcus
mutans) 		4 / 7 LYS A 388
GLY A 398
ASP A 366
TYR A 342
 None
 1.43A 6ag0C-4i5sA:
undetectable		 6ag0C-4i5sA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4i5s PUTATIVE HISTIDINE
KINASE COVS
VICK-LIKE PROTEIN
(Streptococcus
mutans) 		4 / 6 ILE A 321
LEU A 360
MET A 328
THR A 329
 None
 1.01A 6nmfN-4i5sA:
1.0
6nmfW-4i5sA:
undetectable		 6nmfN-4i5sA:
20.74
6nmfW-4i5sA:
8.31