SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i5u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 4i5u CHIMERIC CEL6A
(Chaetomium
thermophilum;
Humicola
insolens;
Trichoderma
reesei) 		5 / 12 PHE A 435
LEU A 439
PHE A 375
ALA A 127
HIS A 109
 None
 1.34A 1a4lB-4i5uA:
4.5		 1a4lB-4i5uA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3001_1
(SERUM ALBUMIN)		 4i5u CHIMERIC CEL6A
(Chaetomium
thermophilum;
Humicola
insolens;
Trichoderma
reesei) 		5 / 11 TYR A 104
LEU A 121
ARG A 122
LEU A 439
ALA A 112
 None
 1.18A 1hk1A-4i5uA:
undetectable		 1hk1A-4i5uA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3001_1
(SERUM ALBUMIN)		 4i5u CHIMERIC CEL6A
(Chaetomium
thermophilum;
Humicola
insolens;
Trichoderma
reesei) 		5 / 11 TYR A 104
LEU A 121
ARG A 122
LEU A 439
ALA A 112
 None
 1.26A 1hk3A-4i5uA:
undetectable		 1hk3A-4i5uA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4D_B_TOYB501_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 4i5u CHIMERIC CEL6A
(Chaetomium
thermophilum;
Humicola
insolens;
Trichoderma
reesei) 		5 / 9 ASP A 171
GLU A 220
SER A 182
ALA A 181
ASP A 138
 None
None
EDO  A 507 ( 4.3A)
None
None
 1.11A 1m4dB-4i5uA:
1.0		 1m4dB-4i5uA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_SAMB293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4i5u CHIMERIC CEL6A
(Humicola
insolens;
Trichoderma
reesei;
Chaetomium
thermophilum) 		5 / 12 TYR A 318
ASP A 401
ASN A 303
HIS A 267
ILE A 312
 None
None
None
EDO  A 512 (-4.2A)
None
 1.31A 1xvaB-4i5uA:
1.9		 1xvaB-4i5uA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_A_3TCA302_1
(DEOXYCYTIDINE KINASE)		 4i5u CHIMERIC CEL6A
(Chaetomium
thermophilum;
Humicola
insolens;
Trichoderma
reesei) 		5 / 12 ILE A 247
LEU A 297
PHE A 343
ALA A 345
PHE A 284
 None
 1.39A 2noaA-4i5uA:
undetectable		 2noaA-4i5uA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 4i5u CHIMERIC CEL6A
(Humicola
insolens;
Trichoderma
reesei;
Chaetomium
thermophilum) 		4 / 5 GLN A 432
ALA A 112
ILE A 116
ARG A 122
 None
 1.49A 2z0aA-4i5uA:
undetectable		 2z0aA-4i5uA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 4i5u CHIMERIC CEL6A
(Humicola
insolens;
Trichoderma
reesei;
Chaetomium
thermophilum) 		5 / 12 THR A 302
GLY A 266
GLY A 299
ASN A 303
LEU A 271
 None
 1.17A 3eeyD-4i5uA:
undetectable		 3eeyD-4i5uA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 4i5u CHIMERIC CEL6A
(Humicola
insolens;
Trichoderma
reesei;
Chaetomium
thermophilum) 		5 / 12 THR A 302
GLY A 266
GLY A 299
ASN A 303
LEU A 271
 None
 1.19A 3eeyH-4i5uA:
undetectable		 3eeyH-4i5uA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4i5u CHIMERIC CEL6A
(Humicola
insolens;
Trichoderma
reesei;
Chaetomium
thermophilum) 		5 / 12 LEU A 439
GLY A 398
GLY A 397
PRO A 396
ALA A 112
 None
None
None
EDO  A 505 ( 4.7A)
None
 1.22A 3i5uA-4i5uA:
undetectable		 3i5uA-4i5uA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 4i5u CHIMERIC CEL6A
(Humicola
insolens;
Trichoderma
reesei;
Chaetomium
thermophilum) 		5 / 12 LEU A 439
GLY A 398
GLY A 397
PRO A 396
ALA A 112
 None
None
None
EDO  A 505 ( 4.7A)
None
 1.20A 3i5uB-4i5uA:
undetectable		 3i5uB-4i5uA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4i5u CHIMERIC CEL6A
(Chaetomium
thermophilum;
Humicola
insolens;
Trichoderma
reesei) 		5 / 8 ASP A 118
HIS A 109
LEU A 447
LEU A 121
SER A 126
 None
 1.34A 3lm8B-4i5uA:
undetectable
3lm8D-4i5uA:
undetectable		 3lm8B-4i5uA:
19.78
3lm8D-4i5uA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4i5u CHIMERIC CEL6A
(Chaetomium
thermophilum;
Humicola
insolens;
Trichoderma
reesei) 		3 / 3 ARG A 105
THR A 149
TRP A  99
 None
 1.27A 4d7hA-4i5uA:
undetectable		 4d7hA-4i5uA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 4i5u CHIMERIC CEL6A
(Chaetomium
thermophilum;
Humicola
insolens;
Trichoderma
reesei) 		4 / 7 PHE A 435
PHE A 375
ALA A 442
LEU A 121
 None
 1.05A 4ejgA-4i5uA:
undetectable		 4ejgA-4i5uA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4i5u CHIMERIC CEL6A
(Humicola
insolens;
Trichoderma
reesei;
Chaetomium
thermophilum) 		4 / 7 GLY A 397
GLY A 398
TYR A 434
ASN A 369
 None
 1.05A 4fgkB-4i5uA:
undetectable		 4fgkB-4i5uA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4i5u CHIMERIC CEL6A
(Humicola
insolens;
Trichoderma
reesei;
Chaetomium
thermophilum) 		4 / 4 ALA A 120
ALA A 123
ALA A 124
ALA A 127
 None
 0.13A 4oadA-4i5uA:
undetectable		 4oadA-4i5uA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4i5u CHIMERIC CEL6A
(Humicola
insolens;
Trichoderma
reesei;
Chaetomium
thermophilum) 		4 / 7 CYH A 246
ILE A 247
PRO A 173
ILE A 188
 ACT  A 502 ( 3.9A)
None
None
None
 0.98A 4w5oA-4i5uA:
undetectable		 4w5oA-4i5uA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4i5u CHIMERIC CEL6A
(Humicola
insolens;
Trichoderma
reesei;
Chaetomium
thermophilum) 		4 / 6 CYH A 246
ILE A 247
ILE A 188
ASP A 174
 ACT  A 502 ( 3.9A)
None
None
EDO  A 507 (-4.2A)
 1.19A 4w5qA-4i5uA:
undetectable		 4w5qA-4i5uA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4i5u CHIMERIC CEL6A
(Humicola
insolens;
Trichoderma
reesei;
Chaetomium
thermophilum) 		4 / 6 CYH A 246
ILE A 247
ILE A 188
ASP A 174
 ACT  A 502 ( 3.9A)
None
None
EDO  A 507 (-4.2A)
 1.17A 4w5tA-4i5uA:
undetectable		 4w5tA-4i5uA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4i5u CHIMERIC CEL6A
(Humicola
insolens;
Trichoderma
reesei;
Chaetomium
thermophilum) 		4 / 6 CYH A 246
ILE A 247
ILE A 188
ASP A 174
 ACT  A 502 ( 3.9A)
None
None
EDO  A 507 (-4.2A)
 1.18A 4z4dA-4i5uA:
undetectable		 4z4dA-4i5uA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4i5u CHIMERIC CEL6A
(Humicola
insolens;
Trichoderma
reesei;
Chaetomium
thermophilum) 		4 / 7 CYH A 246
ILE A 247
PRO A 173
ILE A 188
 ACT  A 502 ( 3.9A)
None
None
None
 0.99A 4z4eA-4i5uA:
undetectable		 4z4eA-4i5uA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4i5u CHIMERIC CEL6A
(Humicola
insolens;
Trichoderma
reesei;
Chaetomium
thermophilum) 		4 / 7 CYH A 246
ILE A 247
PRO A 173
ILE A 188
 ACT  A 502 ( 3.9A)
None
None
None
 0.99A 4z4gA-4i5uA:
undetectable		 4z4gA-4i5uA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 4i5u CHIMERIC CEL6A
(Chaetomium
thermophilum;
Humicola
insolens;
Trichoderma
reesei) 		4 / 6 VAL A 251
ALA A 291
VAL A 287
TYR A 288
 None
None
ACT  A 501 (-4.0A)
None
 0.83A 5i8fA-4i5uA:
undetectable		 5i8fA-4i5uA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4i5u CHIMERIC CEL6A
(Humicola
insolens;
Trichoderma
reesei;
Chaetomium
thermophilum) 		4 / 6 GLY A 184
ASP A 264
ILE A 247
TYR A 243
 EDO  A 507 (-3.3A)
None
None
None
 1.09A 5iwuA-4i5uA:
undetectable		 5iwuA-4i5uA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4i5u CHIMERIC CEL6A
(Chaetomium
thermophilum;
Humicola
insolens;
Trichoderma
reesei) 		5 / 12 ASP A 176
LEU A 283
ALA A 239
PRO A 173
ARG A 175
 None
ACT  A 501 (-4.5A)
None
None
None
 1.34A 5syfB-4i5uA:
undetectable		 5syfB-4i5uA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY4_A_TPFA506_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 4i5u CHIMERIC CEL6A
(Chaetomium
thermophilum;
Humicola
insolens;
Trichoderma
reesei) 		5 / 10 PHE A 334
ALA A 281
PHE A 284
ALA A 285
LEU A 297
 None
 1.20A 6ay4A-4i5uA:
undetectable		 6ay4A-4i5uA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 4i5u CHIMERIC CEL6A
(Humicola
insolens;
Trichoderma
reesei;
Chaetomium
thermophilum) 		4 / 6 CYH A 246
ILE A 247
ILE A 188
ASP A 174
 ACT  A 502 ( 3.9A)
None
None
EDO  A 507 (-4.2A)
 1.17A 6cbdA-4i5uA:
undetectable		 6cbdA-4i5uA:
17.69