SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i5v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 4i5v 5',5'''-P-1,P-4-TETR
APHOSPHATE
PHOSPHORYLASE 2
(Saccharomyces
cerevisiae) 		5 / 12 SER A 113
LEU A 103
TYR A  87
LEU A 253
LEU A 220
 None
 1.28A 1p33C-4i5vA:
undetectable		 1p33C-4i5vA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 4i5v 5',5'''-P-1,P-4-TETR
APHOSPHATE
PHOSPHORYLASE 2
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 127
THR A 254
LEU A 220
LEU A 120
MET A 121
LEU A 208
 None
 1.43A 2ouzA-4i5vA:
undetectable		 2ouzA-4i5vA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 4i5v 5',5'''-P-1,P-4-TETR
APHOSPHATE
PHOSPHORYLASE 2
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 159
GLN A 111
TYR A  87
THR A 122
 None
 1.30A 2vxaF-4i5vA:
0.1
2vxaG-4i5vA:
0.1
2vxaI-4i5vA:
0.1		 2vxaF-4i5vA:
10.13
2vxaG-4i5vA:
10.13
2vxaI-4i5vA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 4i5v 5',5'''-P-1,P-4-TETR
APHOSPHATE
PHOSPHORYLASE 2
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 203
VAL A 205
LEU A 307
GLY A 283
 None
 0.92A 2xfsA-4i5vA:
undetectable		 2xfsA-4i5vA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 4i5v 5',5'''-P-1,P-4-TETR
APHOSPHATE
PHOSPHORYLASE 2
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 203
VAL A 205
LEU A 307
GLY A 283
 None
 0.90A 2xh9A-4i5vA:
undetectable		 2xh9A-4i5vA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 4i5v 5',5'''-P-1,P-4-TETR
APHOSPHATE
PHOSPHORYLASE 2
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 217
ASP A 119
TYR A  87
 None
 0.88A 2yvlB-4i5vA:
undetectable		 2yvlB-4i5vA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4i5v 5',5'''-P-1,P-4-TETR
APHOSPHATE
PHOSPHORYLASE 2
(Saccharomyces
cerevisiae) 		5 / 12 GLN A 195
ALA A 231
THR A 315
PHE A 201
LEU A 252
 None
 1.38A 3aodC-4i5vA:
undetectable		 3aodC-4i5vA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 4i5v 5',5'''-P-1,P-4-TETR
APHOSPHATE
PHOSPHORYLASE 2
(Saccharomyces
cerevisiae) 		4 / 6 ASP A  35
LEU A 307
ASP A 196
LEU A 178
 None
 1.25A 3bj8C-4i5vA:
undetectable
3bj8D-4i5vA:
undetectable		 3bj8C-4i5vA:
20.66
3bj8D-4i5vA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 4i5v 5',5'''-P-1,P-4-TETR
APHOSPHATE
PHOSPHORYLASE 2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  89
LEU A   6
THR A 116
VAL A 126
THR A 122
 None
 1.08A 3dcjA-4i5vA:
undetectable
3dcjB-4i5vA:
undetectable		 3dcjA-4i5vA:
19.58
3dcjB-4i5vA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4i5v 5',5'''-P-1,P-4-TETR
APHOSPHATE
PHOSPHORYLASE 2
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 161
TYR A 147
SER A 113
ASP A 110
 None
 1.03A 4k0bB-4i5vA:
undetectable		 4k0bB-4i5vA:
20.87