SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i62'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 4i62 AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING
PROTEIN, PUTATIVE
(Streptococcus
pneumoniae) 		4 / 8 SER A 175
PHE A  48
SER A 109
ILE A 159
 None
ARG  A 301 (-3.4A)
ARG  A 301 (-2.8A)
ARG  A 301 (-4.0A)
 1.08A 1gm7A-4i62A:
undetectable
1gm7B-4i62A:
undetectable		 1gm7A-4i62A:
21.75
1gm7B-4i62A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 4i62 AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING
PROTEIN, PUTATIVE
(Streptococcus
pneumoniae) 		4 / 6 THR A 244
VAL A 241
LEU A  70
SER A 121
 None
 1.10A 3b6rB-4i62A:
undetectable		 3b6rB-4i62A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 4i62 AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING
PROTEIN, PUTATIVE
(Streptococcus
pneumoniae) 		5 / 11 ALA A 101
VAL A  92
ALA A  71
LEU A  93
PRO A  46
 None
 1.04A 3sm2B-4i62A:
undetectable		 3sm2B-4i62A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4i62 AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING
PROTEIN, PUTATIVE
(Streptococcus
pneumoniae) 		4 / 8 PRO A  86
VAL A  42
LEU A  82
ILE A  63
 None
 0.85A 3u5kA-4i62A:
undetectable		 3u5kA-4i62A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4i62 AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING
PROTEIN, PUTATIVE
(Streptococcus
pneumoniae) 		4 / 8 PRO A  86
VAL A  42
LEU A  82
ILE A  63
 None
 0.90A 3u5kC-4i62A:
undetectable		 3u5kC-4i62A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4i62 AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING
PROTEIN, PUTATIVE
(Streptococcus
pneumoniae) 		4 / 8 PRO A  86
VAL A  42
LEU A  82
ILE A  63
 None
 0.87A 3u5kD-4i62A:
undetectable		 3u5kD-4i62A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 4i62 AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING
PROTEIN, PUTATIVE
(Streptococcus
pneumoniae) 		5 / 11 PHE A  48
GLY A 107
PRO A 199
ALA A 201
GLY A 203
 ARG  A 301 (-3.4A)
ARG  A 301 (-4.7A)
None
None
None
 1.25A 4a6nA-4i62A:
undetectable		 4a6nA-4i62A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 4i62 AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING
PROTEIN, PUTATIVE
(Streptococcus
pneumoniae) 		4 / 7 SER A 109
SER A 158
PHE A  48
GLU A 197
 ARG  A 301 (-2.8A)
ARG  A 301 (-4.8A)
ARG  A 301 (-3.4A)
ARG  A 301 (-2.7A)
 1.20A 4xzkA-4i62A:
undetectable		 4xzkA-4i62A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4i62 AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING
PROTEIN, PUTATIVE
(Streptococcus
pneumoniae) 		3 / 3 ASP A 166
ASN A 129
GLN A 160
 None
None
ARG  A 301 (-3.7A)
 0.68A 5k7uA-4i62A:
undetectable		 5k7uA-4i62A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 4i62 AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING
PROTEIN, PUTATIVE
(Streptococcus
pneumoniae) 		3 / 3 LEU A  70
VAL A 241
ASP A 242
 None
 0.53A 5x23A-4i62A:
undetectable		 5x23A-4i62A:
19.50