SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i66'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 4i66 UNCHARACTERIZED
PROTEIN HOCH_4089
(Haliangium
ochraceum) 		5 / 10 GLU A  57
ARG A  61
GLU A 219
ALA A 221
ALA A 197
 None
 1.27A 1mjqG-4i66A:
undetectable
1mjqH-4i66A:
undetectable		 1mjqG-4i66A:
19.90
1mjqH-4i66A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 4i66 UNCHARACTERIZED
PROTEIN HOCH_4089
(Haliangium
ochraceum) 		5 / 11 LEU A 185
GLY A 178
VAL A 132
LEU A 136
LEU A 228
 None
 0.81A 1mx1B-4i66A:
undetectable		 1mx1B-4i66A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 4i66 UNCHARACTERIZED
PROTEIN HOCH_4089
(Haliangium
ochraceum) 		5 / 12 ILE A 117
VAL A 139
LEU A 105
ALA A  95
PHE A  94
 None
 1.25A 2jj8C-4i66A:
undetectable		 2jj8C-4i66A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4i66 UNCHARACTERIZED
PROTEIN HOCH_4089
(Haliangium
ochraceum) 		5 / 12 LEU A  40
PHE A  94
ILE A 117
SER A  76
VAL A 139
 None
 1.33A 3w1wA-4i66A:
undetectable		 3w1wA-4i66A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 4i66 UNCHARACTERIZED
PROTEIN HOCH_4089
(Haliangium
ochraceum) 		4 / 6 SER A 173
ASP A 129
ARG A 133
GLU A 177
 None
 1.05A 4eysA-4i66A:
3.0		 4eysA-4i66A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4i66 UNCHARACTERIZED
PROTEIN HOCH_4089
(Haliangium
ochraceum) 		6 / 11 GLU A 101
ALA A 104
LEU A 105
LEU A 135
LEU A  88
LEU A 115
 None
 1.43A 4wg0C-4i66A:
undetectable
4wg0D-4i66A:
undetectable
4wg0E-4i66A:
undetectable		 4wg0C-4i66A:
5.39
4wg0D-4i66A:
5.39
4wg0E-4i66A:
5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4i66 UNCHARACTERIZED
PROTEIN HOCH_4089
(Haliangium
ochraceum) 		6 / 11 GLU A 101
ALA A 104
LEU A 105
LEU A 135
LEU A  88
LEU A 115
 None
 1.41A 4wg0E-4i66A:
undetectable
4wg0F-4i66A:
undetectable
4wg0G-4i66A:
undetectable		 4wg0E-4i66A:
5.39
4wg0F-4i66A:
5.39
4wg0G-4i66A:
5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4i66 UNCHARACTERIZED
PROTEIN HOCH_4089
(Haliangium
ochraceum) 		5 / 12 LEU A 116
GLY A 178
PRO A 145
MET A 176
LEU A 185
 None
 1.22A 4x61A-4i66A:
undetectable		 4x61A-4i66A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4i66 UNCHARACTERIZED
PROTEIN HOCH_4089
(Haliangium
ochraceum) 		5 / 10 LEU A  75
LEU A  40
LEU A  88
LEU A 115
LEU A 105
 None
 0.99A 4z91A-4i66A:
undetectable
4z91B-4i66A:
undetectable
4z91C-4i66A:
undetectable
4z91D-4i66A:
undetectable
4z91E-4i66A:
undetectable		 4z91A-4i66A:
24.22
4z91B-4i66A:
24.22
4z91C-4i66A:
24.22
4z91D-4i66A:
24.22
4z91E-4i66A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4i66 UNCHARACTERIZED
PROTEIN HOCH_4089
(Haliangium
ochraceum) 		5 / 10 LEU A  88
LEU A 115
LEU A 105
LEU A  75
LEU A  40
 None
 1.01A 4z91A-4i66A:
undetectable
4z91B-4i66A:
undetectable
4z91C-4i66A:
undetectable
4z91D-4i66A:
undetectable
4z91E-4i66A:
undetectable		 4z91A-4i66A:
24.22
4z91B-4i66A:
24.22
4z91C-4i66A:
24.22
4z91D-4i66A:
24.22
4z91E-4i66A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4i66 UNCHARACTERIZED
PROTEIN HOCH_4089
(Haliangium
ochraceum) 		5 / 10 LEU A 105
LEU A  75
LEU A  40
LEU A  88
LEU A 115
 None
 1.02A 4z91A-4i66A:
undetectable
4z91B-4i66A:
undetectable
4z91C-4i66A:
undetectable
4z91D-4i66A:
undetectable
4z91E-4i66A:
undetectable		 4z91A-4i66A:
24.22
4z91B-4i66A:
24.22
4z91C-4i66A:
24.22
4z91D-4i66A:
24.22
4z91E-4i66A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4i66 UNCHARACTERIZED
PROTEIN HOCH_4089
(Haliangium
ochraceum) 		5 / 10 LEU A 115
LEU A 105
LEU A  75
LEU A  40
LEU A  88
 None
 1.04A 4z91A-4i66A:
undetectable
4z91B-4i66A:
undetectable
4z91C-4i66A:
undetectable
4z91D-4i66A:
undetectable
4z91E-4i66A:
undetectable		 4z91A-4i66A:
24.22
4z91B-4i66A:
24.22
4z91C-4i66A:
24.22
4z91D-4i66A:
24.22
4z91E-4i66A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4i66 UNCHARACTERIZED
PROTEIN HOCH_4089
(Haliangium
ochraceum) 		5 / 12 GLY A 183
PHE A  33
ILE A  58
PHE A  85
HIS A 154
 None
 1.30A 5eslA-4i66A:
undetectable		 5eslA-4i66A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4i66 UNCHARACTERIZED
PROTEIN HOCH_4089
(Haliangium
ochraceum) 		3 / 3 LEU A 124
TYR A 189
SER A 119
 None
 0.89A 5iktA-4i66A:
undetectable		 5iktA-4i66A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 4i66 UNCHARACTERIZED
PROTEIN HOCH_4089
(Haliangium
ochraceum) 		4 / 4 PHE A  94
LEU A 109
LEU A  38
VAL A 139
 None
 1.33A 5xxiA-4i66A:
undetectable		 5xxiA-4i66A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4i66 UNCHARACTERIZED
PROTEIN HOCH_4089
(Haliangium
ochraceum) 		5 / 12 GLY A 183
PHE A  33
ILE A  58
PHE A  85
HIS A 154
 None
 1.22A 6e8qA-4i66A:
undetectable		 6e8qA-4i66A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 4i66 UNCHARACTERIZED
PROTEIN HOCH_4089
(Haliangium
ochraceum) 		5 / 11 ILE A  46
ALA A  39
TYR A  87
LEU A  88
ALA A  50
 None
 1.12A 6ieyA-4i66A:
2.9
6ieyB-4i66A:
3.0		 6ieyA-4i66A:
23.03
6ieyB-4i66A:
23.03