SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i6f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		5 / 12 ILE A 189
GLY A 267
VAL A 269
SER A 313
MET A 314
 None
 1.21A 1nbhA-4i6fA:
undetectable		 1nbhA-4i6fA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		5 / 12 ILE A 189
GLY A 267
VAL A 269
SER A 313
MET A 314
 None
 1.21A 1nbhC-4i6fA:
undetectable		 1nbhC-4i6fA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		5 / 12 ILE A 189
GLY A 267
VAL A 269
SER A 313
MET A 314
 None
 1.22A 1nbhD-4i6fA:
undetectable		 1nbhD-4i6fA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		6 / 12 ALA A 109
GLU A 130
CYH A 162
LEU A 196
HIS A 203
GLY A 222
 1C7  A 401 (-3.2A)
None
1C7  A 401 (-4.1A)
None
None
None
 0.62A 1uwhA-4i6fA:
23.4		 1uwhA-4i6fA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		6 / 12 ALA A 109
GLU A 130
LEU A 196
HIS A 203
GLY A 222
PHE A 212
 1C7  A 401 (-3.2A)
None
None
None
None
1C7  A 401 (-4.0A)
 1.28A 1uwhA-4i6fA:
23.4		 1uwhA-4i6fA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		7 / 12 ALA A 109
LYS A 111
GLU A 130
CYH A 162
LEU A 196
HIS A 203
GLY A 222
 1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
None
1C7  A 401 (-4.1A)
None
None
None
 0.66A 1uwhB-4i6fA:
23.1		 1uwhB-4i6fA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		6 / 12 ALA A 109
GLU A 130
CYH A 162
LEU A 196
HIS A 203
GLY A 222
 1C7  A 401 (-3.2A)
None
1C7  A 401 (-4.1A)
None
None
None
 0.63A 1uwjA-4i6fA:
22.7		 1uwjA-4i6fA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		6 / 12 ALA A 109
GLU A 130
CYH A 162
LEU A 196
HIS A 203
GLY A 222
 1C7  A 401 (-3.2A)
None
1C7  A 401 (-4.1A)
None
None
None
 0.62A 1uwjB-4i6fA:
4.5		 1uwjB-4i6fA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		5 / 12 ALA A 307
ILE A 311
VAL A 182
LEU A 208
ILE A 189
 None
 0.93A 1xozA-4i6fA:
undetectable		 1xozA-4i6fA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		5 / 12 LEU A 206
GLU A 250
GLY A 258
SER A 248
ALA A 259
 None
 1.06A 2br4D-4i6fA:
undetectable		 2br4D-4i6fA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		5 / 12 LEU A 206
GLU A 250
GLY A 258
SER A 248
ALA A 259
 None
 0.99A 2br4F-4i6fA:
undetectable		 2br4F-4i6fA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		4 / 7 MET A 314
ARG A 183
PRO A 279
MET A 299
 None
 1.35A 2hrcA-4i6fA:
undetectable		 2hrcA-4i6fA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA802_0
(FERROCHELATASE)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		4 / 6 MET A 314
ARG A 183
PRO A 279
MET A 299
 None
 1.44A 2qd4A-4i6fA:
undetectable		 2qd4A-4i6fA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		4 / 6 MET A 314
ARG A 183
PRO A 279
MET A 299
 None
 1.31A 3aqiA-4i6fA:
undetectable		 3aqiA-4i6fA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		3 / 3 GLU A 181
VAL A 351
CYH A 347
 None
 0.90A 3fbxA-4i6fA:
undetectable		 3fbxA-4i6fA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		7 / 12 LEU A  88
ALA A 109
LYS A 111
GLU A 130
VAL A 143
ILE A 157
TYR A 161
 1C7  A 401 ( 4.4A)
1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
None
1C7  A 401 (-4.5A)
None
1C7  A 401 (-3.5A)
 0.69A 3k54A-4i6fA:
22.3		 3k54A-4i6fA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		3 / 3 LEU A 137
ARG A 204
ASN A 210
 None
 0.78A 3qxvD-4i6fA:
undetectable		 3qxvD-4i6fA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		5 / 12 VAL A 142
ILE A 155
ILE A 157
LEU A 159
VAL A 143
 None
None
None
1C7  A 401 (-4.0A)
1C7  A 401 (-4.5A)
 1.05A 3w68D-4i6fA:
undetectable		 3w68D-4i6fA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		5 / 12 LEU A  88
ALA A 109
LEU A 159
GLY A 222
ASP A 223
 1C7  A 401 ( 4.4A)
1C7  A 401 (-3.2A)
1C7  A 401 (-4.0A)
None
None
 0.56A 3zbfA-4i6fA:
24.4		 3zbfA-4i6fA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		4 / 5 MET A 314
ARG A 183
PRO A 279
MET A 299
 None
 1.37A 4klaB-4i6fA:
0.0		 4klaB-4i6fA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		6 / 11 ALA A 109
LYS A 111
GLU A 130
ILE A 157
TYR A 161
ASP A 223
 1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
None
None
1C7  A 401 (-3.5A)
None
 0.77A 4qmsA-4i6fA:
30.1		 4qmsA-4i6fA:
27.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		6 / 12 ALA A 109
LYS A 111
ILE A 157
SER A 166
PHE A 212
GLY A 222
 1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
None
None
1C7  A 401 (-4.0A)
None
 0.64A 4rzvA-4i6fA:
22.4		 4rzvA-4i6fA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		6 / 12 ALA A 109
LYS A 111
SER A 166
PHE A 212
GLY A 222
GLY A 225
 1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
None
1C7  A 401 (-4.0A)
None
None
 1.28A 4rzvA-4i6fA:
22.4		 4rzvA-4i6fA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		6 / 12 ALA A 109
LYS A 111
SER A 166
PHE A 212
GLY A 222
PHE A 224
 1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
None
1C7  A 401 (-4.0A)
None
None
 0.94A 4rzvA-4i6fA:
22.4		 4rzvA-4i6fA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		7 / 12 ALA A 109
LYS A 111
CYH A 162
SER A 166
PHE A 212
GLY A 222
GLY A 225
 1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
1C7  A 401 (-4.1A)
None
1C7  A 401 (-4.0A)
None
None
 1.42A 4rzvB-4i6fA:
22.1		 4rzvB-4i6fA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		7 / 12 ALA A 109
LYS A 111
CYH A 162
SER A 166
PHE A 212
GLY A 222
PHE A 224
 1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
1C7  A 401 (-4.1A)
None
1C7  A 401 (-4.0A)
None
None
 1.04A 4rzvB-4i6fA:
22.1		 4rzvB-4i6fA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		7 / 12 ALA A 109
LYS A 111
CYH A 162
PHE A 212
GLY A 222
ASP A 223
PHE A 224
 1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
1C7  A 401 (-4.1A)
1C7  A 401 (-4.0A)
None
None
None
 0.78A 4xv2A-4i6fA:
22.7		 4xv2A-4i6fA:
28.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		7 / 12 ALA A 109
LYS A 111
CYH A 162
PHE A 212
GLY A 222
ASP A 223
PHE A 224
 1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
1C7  A 401 (-4.1A)
1C7  A 401 (-4.0A)
None
None
None
 0.72A 4xv2B-4i6fA:
23.0		 4xv2B-4i6fA:
28.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		4 / 6 ASP A 262
PRO A 278
THR A 272
VAL A 269
 None
 1.01A 4yoaA-4i6fA:
undetectable		 4yoaA-4i6fA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		6 / 12 ALA A 109
LYS A 111
CYH A 162
PHE A 212
GLY A 222
PHE A 224
 1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
1C7  A 401 (-4.1A)
1C7  A 401 (-4.0A)
None
None
 0.78A 5cswA-4i6fA:
22.6		 5cswA-4i6fA:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		6 / 12 ALA A 109
LYS A 111
CYH A 162
PHE A 212
GLY A 222
PHE A 224
 1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
1C7  A 401 (-4.1A)
1C7  A 401 (-4.0A)
None
None
 0.79A 5cswB-4i6fA:
22.6		 5cswB-4i6fA:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		4 / 6 LYS A 111
PHE A 145
SER A 166
ASP A 223
 1C7  A 401 ( 4.7A)
None
None
None
 0.83A 5hesA-4i6fA:
6.8		 5hesA-4i6fA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		7 / 12 ALA A 109
LYS A 111
GLU A 130
CYH A 162
LEU A 196
HIS A 203
GLY A 222
 1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
None
1C7  A 401 (-4.1A)
None
None
None
 0.70A 5hi2A-4i6fA:
22.7		 5hi2A-4i6fA:
27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		5 / 12 ALA A 109
LYS A 111
ILE A 157
PHE A 212
GLY A 222
 1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
None
1C7  A 401 (-4.0A)
None
 0.63A 5hieA-4i6fA:
21.7		 5hieA-4i6fA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		5 / 12 ALA A 109
LYS A 111
ILE A 157
PHE A 212
GLY A 222
 1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
None
1C7  A 401 (-4.0A)
None
 0.65A 5hieB-4i6fA:
21.7		 5hieB-4i6fA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		5 / 12 ALA A 109
LYS A 111
ILE A 157
PHE A 212
GLY A 222
 1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
None
1C7  A 401 (-4.0A)
None
 0.63A 5hieD-4i6fA:
21.8		 5hieD-4i6fA:
27.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		4 / 8 ALA A 109
GLU A 130
CYH A 162
ASP A 223
 1C7  A 401 (-3.2A)
None
1C7  A 401 (-4.1A)
None
 0.52A 5owrA-4i6fA:
23.4		 5owrA-4i6fA:
30.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		5 / 12 ILE A 170
LEU A 208
LEU A 343
PHE A 333
GLY A 267
 None
 0.95A 5uxdB-4i6fA:
4.4		 5uxdB-4i6fA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		7 / 12 GLY A  89
ALA A 109
GLU A 130
TYR A 161
CYH A 162
PHE A 212
ASP A 223
 1C7  A 401 ( 4.8A)
1C7  A 401 (-3.2A)
None
1C7  A 401 (-3.5A)
1C7  A 401 (-4.1A)
1C7  A 401 (-4.0A)
None
 0.81A 5vc3A-4i6fA:
25.2		 5vc3A-4i6fA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		6 / 12 LEU A  88
ALA A 109
GLU A 130
VAL A 143
PHE A 212
GLY A 222
 1C7  A 401 ( 4.4A)
1C7  A 401 (-3.2A)
None
1C7  A 401 (-4.5A)
1C7  A 401 (-4.0A)
None
 0.69A 5vcvA-4i6fA:
24.8		 5vcvA-4i6fA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		6 / 12 LEU A  88
ALA A 109
LYS A 111
GLU A 130
VAL A 143
GLY A 222
 1C7  A 401 ( 4.4A)
1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
None
1C7  A 401 (-4.5A)
None
 0.85A 5vcvA-4i6fA:
24.8		 5vcvA-4i6fA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens) 		5 / 10 LEU A 303
ALA A 307
TYR A 271
PRO A 279
GLU A 281
 None
 1.49A 6b89A-4i6fA:
undetectable		 6b89A-4i6fA:
14.24