SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i6j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 4i6j F-BOX/LRR-REPEAT
PROTEIN 3
(Homo
sapiens) 		5 / 10 LEU B 144
ILE B 179
LEU B 200
LEU B 174
VAL B 167
 None
 1.20A 1cqpA-4i6jB:
undetectable
1cqpB-4i6jB:
undetectable		 1cqpA-4i6jB:
19.69
1cqpB-4i6jB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4i6j F-BOX/LRR-REPEAT
PROTEIN 3
(Homo
sapiens) 		5 / 12 ILE B 216
ALA B 220
LEU B 255
SER B 276
ILE B 272
 None
 1.17A 1ddsB-4i6jB:
undetectable		 1ddsB-4i6jB:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4i6j F-BOX/LRR-REPEAT
PROTEIN 3
(Homo
sapiens) 		5 / 11 PHE B 379
LEU B 324
VAL B 319
PHE B 315
VAL B 327
 None
 1.41A 1q23L-4i6jB:
undetectable		 1q23L-4i6jB:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4i6j F-BOX/LRR-REPEAT
PROTEIN 3
(Homo
sapiens) 		5 / 12 ILE B 216
ALA B 220
LEU B 255
SER B 276
ILE B 272
 None
 1.17A 1rx3A-4i6jB:
undetectable		 1rx3A-4i6jB:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 4i6j F-BOX/LRR-REPEAT
PROTEIN 3
(Homo
sapiens) 		3 / 3 MET B 329
VAL B 339
GLU B 298
 None
 0.86A 2x9gA-4i6jB:
undetectable		 2x9gA-4i6jB:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4i6j F-BOX/LRR-REPEAT
PROTEIN 3
(Homo
sapiens) 		4 / 7 LEU B 131
LEU B 142
SER B 138
THR B 199
 None
 0.94A 3lm8B-4i6jB:
undetectable
3lm8D-4i6jB:
undetectable		 3lm8B-4i6jB:
20.57
3lm8D-4i6jB:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4i6j F-BOX/LRR-REPEAT
PROTEIN 3
(Homo
sapiens) 		5 / 9 LEU B 144
PHE B 115
VAL B 117
ILE B 130
ALA B 126
 None
 1.13A 3mdtA-4i6jB:
undetectable		 3mdtA-4i6jB:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4i6j F-BOX/LRR-REPEAT
PROTEIN 3
(Homo
sapiens) 		6 / 9 LEU B 144
PHE B 115
VAL B 117
ILE B 130
ALA B 126
ALA B 163
 None
 1.13A 3mdvA-4i6jB:
undetectable		 3mdvA-4i6jB:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4i6j F-BOX/LRR-REPEAT
PROTEIN 3
(Homo
sapiens) 		6 / 12 LEU B 144
PHE B 115
VAL B 117
ILE B 130
ALA B 126
ALA B 163
 None
 1.13A 3mdvB-4i6jB:
undetectable		 3mdvB-4i6jB:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4i6j F-BOX/LRR-REPEAT
PROTEIN 3
(Homo
sapiens) 		5 / 10 PHE B 379
LEU B 324
VAL B 319
PHE B 315
VAL B 327
 None
 1.46A 3u9fE-4i6jB:
undetectable		 3u9fE-4i6jB:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4i6j F-BOX/LRR-REPEAT
PROTEIN 3
(Homo
sapiens) 		5 / 10 PHE B 379
LEU B 324
VAL B 319
PHE B 315
VAL B 327
 None
 1.43A 3u9fR-4i6jB:
undetectable		 3u9fR-4i6jB:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4i6j F-BOX/LRR-REPEAT
PROTEIN 3
(Homo
sapiens) 		5 / 12 PHE B 379
LEU B 324
VAL B 319
PHE B 315
VAL B 327
 None
 1.43A 3u9fP-4i6jB:
undetectable
3u9fS-4i6jB:
undetectable		 3u9fP-4i6jB:
19.62
3u9fS-4i6jB:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 4i6j F-BOX/LRR-REPEAT
PROTEIN 3
(Homo
sapiens) 		4 / 5 VAL B 380
LEU B 387
LEU B 416
ILE B 392
 None
 0.89A 4a9jB-4i6jB:
undetectable		 4a9jB-4i6jB:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 4i6j F-BOX/LRR-REPEAT
PROTEIN 3
(Homo
sapiens) 		4 / 5 VAL B 380
LEU B 387
LEU B 416
ILE B 392
 None
 0.85A 4a9jC-4i6jB:
undetectable		 4a9jC-4i6jB:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4i6j F-BOX/LRR-REPEAT
PROTEIN 3
(Homo
sapiens) 		5 / 12 ILE B 216
ALA B 220
LEU B 255
SER B 276
ILE B 272
 None
 1.28A 4gh8B-4i6jB:
undetectable		 4gh8B-4i6jB:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4i6j F-BOX/LRR-REPEAT
PROTEIN 3
(Homo
sapiens) 		6 / 12 GLY B 384
GLY B 385
LEU B 361
SER B 362
ALA B 355
HIS B 415
 None
 1.33A 4htfA-4i6jB:
undetectable		 4htfA-4i6jB:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 4i6j F-BOX/LRR-REPEAT
PROTEIN 3
(Homo
sapiens) 		5 / 11 ALA B 243
LEU B 240
LEU B 231
VAL B 219
HIS B 249
 None
 1.33A 5eb5A-4i6jB:
undetectable		 5eb5A-4i6jB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4i6j F-BOX/LRR-REPEAT
PROTEIN 3
(Homo
sapiens) 		5 / 12 ILE B 392
VAL B 380
GLU B 349
ALA B 355
GLY B 328
 None
 0.89A 5igjA-4i6jB:
undetectable		 5igjA-4i6jB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4i6j F-BOX/LRR-REPEAT
PROTEIN 3
(Homo
sapiens) 		5 / 12 ILE B 392
VAL B 380
GLU B 349
ALA B 355
GLY B 328
 None
 0.93A 5igtA-4i6jB:
undetectable		 5igtA-4i6jB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYN_A_HSMA901_0
(EBONY)		 4i6j F-BOX/LRR-REPEAT
PROTEIN 3
(Homo
sapiens) 		4 / 4 GLU B 262
VAL B 260
LEU B 295
THR B 267
 None
 1.30A 6dynA-4i6jB:
undetectable		 6dynA-4i6jB:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 4i6j F-BOX/LRR-REPEAT
PROTEIN 3
(Homo
sapiens) 		4 / 5 GLU B 262
VAL B 260
LEU B 295
THR B 267
 None
 1.28A 6dyoA-4i6jB:
undetectable		 6dyoA-4i6jB:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 4i6j F-BOX/LRR-REPEAT
PROTEIN 3
(Homo
sapiens) 		5 / 9 LEU B 397
SER B 372
PHE B 376
LEU B 351
VAL B 412
 None
 1.29A 6ftpA-4i6jB:
undetectable
6ftpB-4i6jB:
undetectable		 6ftpA-4i6jB:
10.70
6ftpB-4i6jB:
7.49