SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i6k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 4i6k AMIDOHYDROLASE
FAMILY PROTEIN
(Acinetobacter
baumannii) 		3 / 3 ALA A 205
VAL A 189
TRP A 223
 None
 0.92A 1av2A-4i6kA:
undetectable
1av2B-4i6kA:
undetectable		 1av2A-4i6kA:
6.03
1av2B-4i6kA:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 4i6k AMIDOHYDROLASE
FAMILY PROTEIN
(Acinetobacter
baumannii) 		4 / 5 PHE A 152
TYR A 150
LEU A 112
VAL A 100
 None
 1.35A 1dz6A-4i6kA:
undetectable		 1dz6A-4i6kA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 4i6k AMIDOHYDROLASE
FAMILY PROTEIN
(Acinetobacter
baumannii) 		3 / 3 ALA A 205
VAL A 189
TRP A 223
 None
 0.90A 1w5uA-4i6kA:
undetectable
1w5uB-4i6kA:
undetectable		 1w5uA-4i6kA:
6.03
1w5uB-4i6kA:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4i6k AMIDOHYDROLASE
FAMILY PROTEIN
(Acinetobacter
baumannii) 		5 / 11 TRP A 227
LEU A  50
HIS A  11
HIS A 158
ALA A 241
 None
None
CIT  A 301 (-4.1A)
CIT  A 301 (-4.1A)
None
 1.46A 2a58A-4i6kA:
undetectable
2a58E-4i6kA:
undetectable		 2a58A-4i6kA:
18.77
2a58E-4i6kA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4i6k AMIDOHYDROLASE
FAMILY PROTEIN
(Acinetobacter
baumannii) 		5 / 11 HIS A 158
ALA A 241
TRP A 227
LEU A  50
HIS A  11
 CIT  A 301 (-4.1A)
None
None
None
CIT  A 301 (-4.1A)
 1.46A 2a58C-4i6kA:
undetectable
2a58D-4i6kA:
undetectable		 2a58C-4i6kA:
18.77
2a58D-4i6kA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 4i6k AMIDOHYDROLASE
FAMILY PROTEIN
(Acinetobacter
baumannii) 		3 / 3 TRP A 223
ALA A 205
VAL A 189
 None
 0.93A 2izqC-4i6kA:
undetectable
2izqD-4i6kA:
undetectable		 2izqC-4i6kA:
6.03
2izqD-4i6kA:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 4i6k AMIDOHYDROLASE
FAMILY PROTEIN
(Acinetobacter
baumannii) 		5 / 12 LEU A 109
LEU A 140
LEU A 143
GLY A 160
HIS A 158
 None
None
None
None
CIT  A 301 (-4.1A)
 0.89A 2ouzA-4i6kA:
undetectable		 2ouzA-4i6kA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 4i6k AMIDOHYDROLASE
FAMILY PROTEIN
(Acinetobacter
baumannii) 		4 / 7 GLY A 268
ILE A   6
THR A   8
LEU A 266
 None
 0.75A 2xrhA-4i6kA:
undetectable		 2xrhA-4i6kA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 4i6k AMIDOHYDROLASE
FAMILY PROTEIN
(Acinetobacter
baumannii) 		3 / 3 TRP A 223
ALA A 205
VAL A 189
 None
 0.94A 3l8lC-4i6kA:
undetectable
3l8lD-4i6kA:
undetectable		 3l8lC-4i6kA:
6.03
3l8lD-4i6kA:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 4i6k AMIDOHYDROLASE
FAMILY PROTEIN
(Acinetobacter
baumannii) 		5 / 12 LEU A  64
ALA A  62
LEU A  56
ILE A  97
LEU A  50
 None
 1.02A 3olsB-4i6kA:
undetectable		 3olsB-4i6kA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 4i6k AMIDOHYDROLASE
FAMILY PROTEIN
(Acinetobacter
baumannii) 		4 / 5 SER A 190
GLY A 224
VAL A  49
ASP A   7
 None
 1.11A 4eohA-4i6kA:
undetectable		 4eohA-4i6kA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 4i6k AMIDOHYDROLASE
FAMILY PROTEIN
(Acinetobacter
baumannii) 		4 / 8 VAL A 162
GLN A 174
GLN A 206
ILE A 211
 None
 1.02A 4iilA-4i6kA:
undetectable		 4iilA-4i6kA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 4i6k AMIDOHYDROLASE
FAMILY PROTEIN
(Acinetobacter
baumannii) 		5 / 6 HIS A   9
HIS A  11
HIS A 134
HIS A 158
ASP A 226
 CIT  A 301 (-4.1A)
CIT  A 301 (-4.1A)
CIT  A 301 (-3.9A)
CIT  A 301 (-4.1A)
CIT  A 301 (-2.5A)
 1.02A 4ubpC-4i6kA:
11.4		 4ubpC-4i6kA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4i6k AMIDOHYDROLASE
FAMILY PROTEIN
(Acinetobacter
baumannii) 		4 / 7 ILE A 248
ILE A 222
ASN A 210
PHE A 217
 None
 0.98A 5hieC-4i6kA:
undetectable		 5hieC-4i6kA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4i6k AMIDOHYDROLASE
FAMILY PROTEIN
(Acinetobacter
baumannii) 		5 / 12 VAL A  79
THR A  58
PHE A 120
LEU A 121
VAL A 124
 None
 1.37A 6a93B-4i6kA:
undetectable		 6a93B-4i6kA:
21.59