SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i6n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4i6n UBIQUITIN
CARBOXYL-HYDROLASE
(Trichinella
spiralis) 		5 / 12 ILE A 222
ALA A 220
LEU A 218
LEU A  90
ALA A  89
 None
 1.24A 1g5yB-4i6nA:
undetectable		 1g5yB-4i6nA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 4i6n UBIQUITIN
CARBOXYL-HYDROLASE
(Trichinella
spiralis) 		5 / 12 THR A 128
LEU A 127
ILE A 133
VAL A 136
LEU A  95
 None
 1.32A 1wsvA-4i6nA:
undetectable		 1wsvA-4i6nA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 4i6n UBIQUITIN
CARBOXYL-HYDROLASE
(Trichinella
spiralis) 		5 / 12 THR A 128
LEU A 127
ILE A 133
VAL A 136
LEU A  95
 None
 1.31A 1wsvB-4i6nA:
undetectable		 1wsvB-4i6nA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 4i6n UBIQUITIN
CARBOXYL-HYDROLASE
(Trichinella
spiralis) 		3 / 3 THR A  70
PRO A  68
THR A  72
 None
 0.74A 209dC-4i6nA:
undetectable		 209dC-4i6nA:
3.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 4i6n UBIQUITIN
CARBOXYL-HYDROLASE
(Trichinella
spiralis) 		5 / 12 LEU A  36
LEU A 218
ILE A 199
ALA A 220
PHE A  49
 None
 0.86A 2qb4A-4i6nA:
undetectable		 2qb4A-4i6nA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 4i6n UBIQUITIN
CARBOXYL-HYDROLASE
(Trichinella
spiralis) 		5 / 11 LEU A  36
LEU A 218
ILE A 199
ALA A 220
PHE A  49
 None
 0.83A 2qjuA-4i6nA:
undetectable		 2qjuA-4i6nA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 4i6n UBIQUITIN
CARBOXYL-HYDROLASE
(Trichinella
spiralis) 		4 / 5 VAL A 166
TYR A 173
VAL A  74
ASP A  73
 None
 1.15A 2x45A-4i6nA:
undetectable		 2x45A-4i6nA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 4i6n UBIQUITIN
CARBOXYL-HYDROLASE
(Trichinella
spiralis) 		4 / 8 LEU A 127
LEU A  90
ASN A  92
LEU A  95
 None
 1.18A 2xn3A-4i6nA:
undetectable
2xn3B-4i6nA:
undetectable		 2xn3A-4i6nA:
21.59
2xn3B-4i6nA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 4i6n UBIQUITIN
CARBOXYL-HYDROLASE
(Trichinella
spiralis) 		5 / 12 LEU A  36
LEU A 218
ILE A 199
ALA A 220
PHE A  49
 None
 0.82A 3gwwA-4i6nA:
1.1		 3gwwA-4i6nA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 4i6n UBIQUITIN
CARBOXYL-HYDROLASE
(Trichinella
spiralis) 		3 / 3 GLU A 204
GLU A  59
ASN A 208
 None
 0.79A 3lp9B-4i6nA:
undetectable
3lp9D-4i6nA:
undetectable		 3lp9B-4i6nA:
18.70
3lp9D-4i6nA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4i6n UBIQUITIN
CARBOXYL-HYDROLASE
(Trichinella
spiralis) 		5 / 9 ALA A 198
ILE A 222
VAL A  30
GLY A  48
ILE A 202
 None
 1.04A 4r21B-4i6nA:
undetectable		 4r21B-4i6nA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4i6n UBIQUITIN
CARBOXYL-HYDROLASE
(Trichinella
spiralis) 		5 / 12 VAL A 168
GLY A  48
TYR A 173
GLN A 225
HIS A  47
 None
 1.30A 4xucA-4i6nA:
undetectable		 4xucA-4i6nA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4i6n UBIQUITIN
CARBOXYL-HYDROLASE
(Trichinella
spiralis) 		5 / 12 VAL A 168
GLY A  48
TYR A 173
GLN A 225
HIS A  47
 None
 1.33A 4xudA-4i6nA:
undetectable		 4xudA-4i6nA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 4i6n UBIQUITIN
CARBOXYL-HYDROLASE
(Trichinella
spiralis) 		4 / 6 LEU A  90
LEU A  93
LEU A 108
HIS A  21
 None
 0.95A 5gs4A-4i6nA:
undetectable		 5gs4A-4i6nA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 4i6n UBIQUITIN
CARBOXYL-HYDROLASE
(Trichinella
spiralis) 		4 / 6 GLN A  79
TRP A   6
HIS A 137
GLN A  88
 None
 1.37A 6f6jC-4i6nA:
undetectable
6f6jD-4i6nA:
undetectable		 6f6jC-4i6nA:
20.92
6f6jD-4i6nA:
20.92