SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i6v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 4i6v AMIDOHYDROLASE 2
(Planctopirus
limnophila) 		4 / 6 HIS A 204
ASP A 148
ASP A 145
PRO A 160
 None
 1.34A 1ilqA-4i6vA:
undetectable
1ilqC-4i6vA:
undetectable		 1ilqA-4i6vA:
9.51
1ilqC-4i6vA:
3.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4i6v AMIDOHYDROLASE 2
(Planctopirus
limnophila) 		3 / 3 ASP A 374
HIS A  25
HIS A  27
 ZN  A 501 (-2.6A)
ZN  A 501 (-3.4A)
ZN  A 501 (-3.2A)
 0.68A 1oe1A-4i6vA:
undetectable		 1oe1A-4i6vA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4i6v AMIDOHYDROLASE 2
(Planctopirus
limnophila) 		3 / 3 ASP A 374
HIS A  25
HIS A  27
 ZN  A 501 (-2.6A)
ZN  A 501 (-3.4A)
ZN  A 501 (-3.2A)
 0.68A 1oe3A-4i6vA:
undetectable		 1oe3A-4i6vA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 4i6v AMIDOHYDROLASE 2
(Planctopirus
limnophila) 		4 / 8 PHE A 380
TYR A  46
GLY A  39
TYR A 376
 None
GOL  A 503 (-4.4A)
None
None
 0.92A 1rmtC-4i6vA:
undetectable		 1rmtC-4i6vA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 4i6v AMIDOHYDROLASE 2
(Planctopirus
limnophila) 		5 / 12 VAL A 337
PHE A 169
VAL A 168
PHE A 271
LEU A 305
 None
GOL  A 502 (-4.4A)
None
None
None
 1.22A 2ft9A-4i6vA:
undetectable		 2ft9A-4i6vA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 4i6v AMIDOHYDROLASE 2
(Planctopirus
limnophila) 		4 / 8 TYR A 372
ASP A 374
TYR A 371
TYR A  46
 None
ZN  A 501 (-2.6A)
None
GOL  A 503 (-4.4A)
 1.07A 2ha2A-4i6vA:
undetectable		 2ha2A-4i6vA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 4i6v AMIDOHYDROLASE 2
(Planctopirus
limnophila) 		4 / 8 TYR A 372
ASP A 374
TYR A 371
TYR A  46
 None
ZN  A 501 (-2.6A)
None
GOL  A 503 (-4.4A)
 1.05A 2ha2B-4i6vA:
undetectable		 2ha2B-4i6vA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4i6v AMIDOHYDROLASE 2
(Planctopirus
limnophila) 		5 / 12 ARG A 420
GLY A 370
ILE A 426
ASN A 422
PHE A 141
 None
 1.16A 2zznA-4i6vA:
undetectable		 2zznA-4i6vA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4i6v AMIDOHYDROLASE 2
(Planctopirus
limnophila) 		3 / 3 LEU A 419
TRP A 382
TYR A 371
 None
 0.78A 3aicA-4i6vA:
undetectable		 3aicA-4i6vA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4i6v AMIDOHYDROLASE 2
(Planctopirus
limnophila) 		3 / 3 LEU A 419
TRP A 382
TYR A 371
 None
 0.77A 3aicB-4i6vA:
undetectable		 3aicB-4i6vA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4i6v AMIDOHYDROLASE 2
(Planctopirus
limnophila) 		3 / 3 LEU A 419
TRP A 382
TYR A 371
 None
 0.77A 3aicE-4i6vA:
2.2		 3aicE-4i6vA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4i6v AMIDOHYDROLASE 2
(Planctopirus
limnophila) 		3 / 3 LEU A 419
TRP A 382
TYR A 371
 None
 0.81A 3aicF-4i6vA:
undetectable		 3aicF-4i6vA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4i6v AMIDOHYDROLASE 2
(Planctopirus
limnophila) 		3 / 3 LEU A 419
TRP A 382
TYR A 371
 None
 0.81A 3aicG-4i6vA:
undetectable		 3aicG-4i6vA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4i6v AMIDOHYDROLASE 2
(Planctopirus
limnophila) 		3 / 3 LEU A 419
TRP A 382
TYR A 371
 None
 0.76A 3aicH-4i6vA:
undetectable		 3aicH-4i6vA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 4i6v AMIDOHYDROLASE 2
(Planctopirus
limnophila) 		3 / 3 CYH A 264
HIS A 267
PHE A 263
 None
 1.14A 3cr4X-4i6vA:
undetectable		 3cr4X-4i6vA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 4i6v AMIDOHYDROLASE 2
(Planctopirus
limnophila) 		3 / 3 CYH A  95
PHE A  98
PHE A  99
 None
 1.08A 3cr5X-4i6vA:
undetectable		 3cr5X-4i6vA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 4i6v AMIDOHYDROLASE 2
(Planctopirus
limnophila) 		4 / 6 ILE A 316
LYS A 367
ILE A 369
HIS A  25
 None
None
None
ZN  A 501 (-3.4A)
 0.90A 3eteA-4i6vA:
undetectable
3eteE-4i6vA:
undetectable		 3eteA-4i6vA:
22.81
3eteE-4i6vA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 4i6v AMIDOHYDROLASE 2
(Planctopirus
limnophila) 		4 / 7 LYS A 367
ILE A 369
HIS A  25
ILE A 316
 None
None
ZN  A 501 (-3.4A)
None
 0.91A 3eteD-4i6vA:
undetectable
3eteF-4i6vA:
undetectable		 3eteD-4i6vA:
22.81
3eteF-4i6vA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 4i6v AMIDOHYDROLASE 2
(Planctopirus
limnophila) 		5 / 10 SER A 346
LEU A 299
SER A 323
ILE A 275
GLY A 276
 None
 1.43A 3ik6B-4i6vA:
undetectable
3ik6E-4i6vA:
undetectable		 3ik6B-4i6vA:
19.55
3ik6E-4i6vA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 4i6v AMIDOHYDROLASE 2
(Planctopirus
limnophila) 		4 / 6 SER A 253
PHE A 257
ILE A 215
PHE A 146
 None
 0.91A 3ko0S-4i6vA:
undetectable		 3ko0S-4i6vA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 4i6v AMIDOHYDROLASE 2
(Planctopirus
limnophila) 		4 / 8 LEU A 378
SER A  26
SER A 373
TYR A 158
 None
 0.90A 3rodA-4i6vA:
undetectable		 3rodA-4i6vA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 4i6v AMIDOHYDROLASE 2
(Planctopirus
limnophila) 		5 / 12 VAL A 297
LEU A 217
ILE A 316
GLN A 301
LEU A 299
 None
 1.30A 4o5fA-4i6vA:
undetectable
4o5fB-4i6vA:
undetectable		 4o5fA-4i6vA:
22.07
4o5fB-4i6vA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 4i6v AMIDOHYDROLASE 2
(Planctopirus
limnophila) 		5 / 12 GLN A 301
LEU A 299
VAL A 297
LEU A 217
ILE A 316
 None
 1.29A 4o5fA-4i6vA:
undetectable
4o5fB-4i6vA:
undetectable		 4o5fA-4i6vA:
22.07
4o5fB-4i6vA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 4i6v AMIDOHYDROLASE 2
(Planctopirus
limnophila) 		4 / 8 ILE A 215
LEU A 217
LEU A 305
PHE A 306
 None
 0.78A 4qopC-4i6vA:
undetectable		 4qopC-4i6vA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 4i6v AMIDOHYDROLASE 2
(Planctopirus
limnophila) 		5 / 12 VAL A 297
LEU A 217
ILE A 316
GLN A 301
LEU A 299
 None
 1.26A 5b8hA-4i6vA:
undetectable
5b8hB-4i6vA:
undetectable		 5b8hA-4i6vA:
21.25
5b8hB-4i6vA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 4i6v AMIDOHYDROLASE 2
(Planctopirus
limnophila) 		5 / 12 GLN A 301
LEU A 299
VAL A 297
LEU A 217
ILE A 316
 None
 1.25A 5b8hA-4i6vA:
undetectable
5b8hB-4i6vA:
undetectable		 5b8hA-4i6vA:
21.25
5b8hB-4i6vA:
21.25