SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i70'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE
(Trypanosoma
brucei) 		5 / 11 CYH A 135
LEU A   7
THR A 137
THR A 264
VAL A 162
 None
 1.17A 1pkvA-4i70A:
undetectable
1pkvB-4i70A:
undetectable		 1pkvA-4i70A:
16.10
1pkvB-4i70A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE
(Trypanosoma
brucei) 		5 / 11 VAL A 162
CYH A 135
LEU A   7
THR A 137
THR A 264
 None
 1.18A 1pkvA-4i70A:
undetectable
1pkvB-4i70A:
undetectable		 1pkvA-4i70A:
16.10
1pkvB-4i70A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE
(Trypanosoma
brucei) 		4 / 6 MET A 237
VAL A 238
LEU A 234
MET A  57
 None
 1.21A 1x8vA-4i70A:
undetectable		 1x8vA-4i70A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE
(Trypanosoma
brucei) 		5 / 11 TRP A 185
ASN A 186
ALA A  73
SER A  71
ASP A  14
 None
CA  A 401 ( 4.3A)
None
None
None
 1.27A 2iyfA-4i70A:
3.4		 2iyfA-4i70A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE
(Trypanosoma
brucei) 		3 / 3 SER A  86
ASP A  10
ASP A  14
 None
CA  A 401 (-3.0A)
None
 0.76A 2plwA-4i70A:
undetectable		 2plwA-4i70A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE
(Trypanosoma
brucei) 		4 / 7 ILE A   6
ARG A 204
ILE A 203
PHE A 154
 None
 1.06A 2q6hA-4i70A:
undetectable		 2q6hA-4i70A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2REZ_A_ACTA156_0
(MULTIFUNCTIONAL
CYCLASE-DEHYDRATASE-
3-O-METHYL
TRANSFERASE TCMN)		 4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE
(Trypanosoma
brucei) 		4 / 7 GLU A 111
TRP A 105
MET A  54
LEU A  65
 None
 1.42A 2rezA-4i70A:
undetectable		 2rezA-4i70A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE
(Trypanosoma
brucei) 		4 / 8 VAL A 174
ARG A 293
TYR A 188
ILE A 187
 None
 0.83A 3remA-4i70A:
undetectable		 3remA-4i70A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE
(Trypanosoma
brucei) 		4 / 8 VAL A 174
ARG A 293
TYR A 188
ILE A 187
 None
 0.81A 3remB-4i70A:
undetectable		 3remB-4i70A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE
(Trypanosoma
brucei) 		5 / 10 VAL A 174
ALA A 167
ARG A 293
TYR A 188
ILE A 187
 None
 1.47A 3retA-4i70A:
undetectable
3retB-4i70A:
undetectable		 3retA-4i70A:
15.58
3retB-4i70A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE
(Trypanosoma
brucei) 		5 / 11 LEU A 269
VAL A  29
LEU A   7
VAL A 134
THR A 133
 None
 1.32A 3tbgA-4i70A:
undetectable		 3tbgA-4i70A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE
(Trypanosoma
brucei) 		4 / 6 LEU A  21
ASN A  25
MET A 241
ILE A  61
 None
 0.98A 4okxA-4i70A:
undetectable		 4okxA-4i70A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE
(Trypanosoma
brucei) 		5 / 10 THR A 294
ALA A 194
ALA A 193
GLY A 166
GLY A 165
 None
 1.02A 4qvpK-4i70A:
undetectable
4qvpL-4i70A:
undetectable		 4qvpK-4i70A:
19.52
4qvpL-4i70A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE
(Trypanosoma
brucei) 		5 / 10 THR A 294
ALA A 194
ALA A 193
GLY A 166
GLY A 165
 None
 1.02A 4qvpY-4i70A:
undetectable
4qvpZ-4i70A:
undetectable		 4qvpY-4i70A:
19.52
4qvpZ-4i70A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE
(Trypanosoma
brucei) 		5 / 11 THR A 294
ALA A 194
ALA A 193
GLY A 166
GLY A 165
 None
 1.03A 4qw1K-4i70A:
undetectable
4qw1L-4i70A:
undetectable		 4qw1K-4i70A:
19.52
4qw1L-4i70A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE
(Trypanosoma
brucei) 		5 / 10 THR A 294
ALA A 194
ALA A 193
GLY A 166
GLY A 165
 None
 1.03A 4qw1Y-4i70A:
undetectable
4qw1Z-4i70A:
undetectable		 4qw1Y-4i70A:
19.52
4qw1Z-4i70A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE
(Trypanosoma
brucei) 		5 / 9 THR A 294
ALA A 194
ALA A 193
GLY A 166
GLY A 165
 None
 1.16A 4qwuK-4i70A:
undetectable
4qwuL-4i70A:
undetectable		 4qwuK-4i70A:
19.52
4qwuL-4i70A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE
(Trypanosoma
brucei) 		5 / 9 THR A 294
ALA A 194
ALA A 193
GLY A 166
GLY A 165
 None
 1.11A 4qwuY-4i70A:
undetectable
4qwuZ-4i70A:
undetectable		 4qwuY-4i70A:
19.52
4qwuZ-4i70A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE
(Trypanosoma
brucei) 		4 / 6 GLY A 181
ASP A 180
ARG A 293
GLY A 171
 None
 0.82A 5cdnA-4i70A:
undetectable
5cdnB-4i70A:
undetectable		 5cdnA-4i70A:
21.91
5cdnB-4i70A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE
(Trypanosoma
brucei) 		5 / 9 LEU A 198
THR A 294
ARG A 293
ILE A 187
GLY A 292
 None
 1.30A 5ifuB-4i70A:
undetectable		 5ifuB-4i70A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE
(Trypanosoma
brucei) 		3 / 3 VAL A 238
SER A  24
MET A  54
 None
 0.83A 5ikqA-4i70A:
undetectable		 5ikqA-4i70A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)		 4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE
(Trypanosoma
brucei) 		5 / 12 ALA A  18
LEU A 319
ARG A 325
VAL A 238
PHE A 226
 None
 1.48A 5vlmC-4i70A:
undetectable		 5vlmC-4i70A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE
(Trypanosoma
brucei) 		5 / 12 ALA A  18
LEU A 319
ARG A 325
VAL A 238
PHE A 226
 None
 1.34A 5vlmD-4i70A:
undetectable		 5vlmD-4i70A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE
(Trypanosoma
brucei) 		4 / 6 GLY A 181
ASP A 180
SER A 290
ARG A 293
 None
 1.18A 6dwdA-4i70A:
undetectable
6dwdC-4i70A:
undetectable		 6dwdA-4i70A:
19.06
6dwdC-4i70A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE
(Trypanosoma
brucei) 		3 / 3 SER A  24
SER A 323
ALA A 262
 None
 0.54A 6dwnC-4i70A:
undetectable		 6dwnC-4i70A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE
(Trypanosoma
brucei) 		4 / 6 LEU A   7
VAL A 223
MET A 164
GLY A 138
 None
None
None
CA  A 401 ( 4.2A)
 1.06A 6hd4B-4i70A:
undetectable		 6hd4B-4i70A:
15.02