SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i7i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 4i7i RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		5 / 11 ARG A 221
LEU A 259
GLU A 397
LEU A 477
GLY A 482
 None
 1.37A 1cmaA-4i7iA:
undetectable
1cmaB-4i7iA:
undetectable		 1cmaA-4i7iA:
12.25
1cmaB-4i7iA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 4i7i RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		4 / 6 LEU A 280
PHE A 316
TYR A 341
VAL A 348
 None
 0.94A 1ibgH-4i7iA:
undetectable		 1ibgH-4i7iA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_A_NIOA704_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4i7i RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		4 / 4 SER A 406
PHE A  42
GLU A  40
GLY A  41
 None
 1.45A 1icvA-4i7iA:
undetectable
1icvB-4i7iA:
undetectable		 1icvA-4i7iA:
17.80
1icvB-4i7iA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4i7i RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		5 / 12 LEU A 443
ASN A  44
ALA A  39
SER A 119
LEU A 121
 None
 1.14A 1ya3B-4i7iA:
undetectable		 1ya3B-4i7iA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 4i7i RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		4 / 5 LEU A 522
LEU A 525
LEU A 484
LEU A 486
 None
 0.73A 2ab2B-4i7iA:
undetectable		 2ab2B-4i7iA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 4i7i RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		5 / 12 LEU A 390
GLY A 212
LEU A 262
THR A 215
LEU A 274
 None
 0.97A 2egvB-4i7iA:
undetectable		 2egvB-4i7iA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 4i7i RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		3 / 3 SER A 119
HIS A 113
ASP A  61
 None
 0.74A 2wa2B-4i7iA:
undetectable		 2wa2B-4i7iA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 4i7i RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		5 / 12 ARG A 493
GLY A 409
ALA A 408
ILE A 404
LEU A 486
 None
 1.02A 3ogqB-4i7iA:
undetectable		 3ogqB-4i7iA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 4i7i RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		5 / 12 VAL A 219
PRO A  60
ILE A 205
VAL A  21
CYH A  66
 None
 1.30A 3p6gA-4i7iA:
undetectable		 3p6gA-4i7iA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 4i7i RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		3 / 3 THR A 232
SER A 258
ARG A 257
 None
 0.73A 3phnA-4i7iA:
undetectable		 3phnA-4i7iA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4i7i RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		4 / 5 LEU A 522
LEU A 525
LEU A 484
SER A 485
 None
 0.91A 3vhuA-4i7iA:
undetectable		 3vhuA-4i7iA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 4i7i RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		4 / 5 ILE A 404
ALA A 400
HIS A 284
ARG A 221
 None
 1.32A 4ac9B-4i7iA:
undetectable
4ac9C-4i7iA:
undetectable		 4ac9B-4i7iA:
21.94
4ac9C-4i7iA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4i7i RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		4 / 5 ILE A 404
ALA A 400
HIS A 284
ARG A 221
 None
 1.31A 4acaB-4i7iA:
undetectable
4acaC-4i7iA:
undetectable		 4acaB-4i7iA:
21.94
4acaC-4i7iA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4i7i RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		4 / 4 LEU A 448
LEU A 521
GLN A 475
GLU A 453
 None
 1.27A 4i41A-4i7iA:
undetectable		 4i41A-4i7iA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4i7i RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		4 / 6 GLY A 409
ILE A  64
ILE A 404
LEU A 448
 None
 0.71A 4o8fB-4i7iA:
undetectable		 4o8fB-4i7iA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA207_0
(OXIDOREDUCTASE)		 4i7i RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		4 / 4 GLU A 248
GLY A 250
HIS A 255
ARG A 257
 None
 0.82A 4r82A-4i7iA:
undetectable
4r82B-4i7iA:
undetectable		 4r82A-4i7iA:
16.74
4r82B-4i7iA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 4i7i RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		5 / 12 LEU A 262
LEU A 280
ILE A 282
VAL A 348
LEU A 390
 None
 0.94A 4y0sA-4i7iA:
undetectable		 4y0sA-4i7iA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4i7i RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		5 / 10 ALA A 400
GLU A 397
LEU A 477
ARG A 221
GLY A 482
 None
 1.37A 5dx3A-4i7iA:
undetectable		 5dx3A-4i7iA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4i7i RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		5 / 10 LEU A 477
ALA A 256
GLU A 397
LEU A 259
GLY A 288
 None
 1.40A 5dx3A-4i7iA:
undetectable		 5dx3A-4i7iA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 4i7i RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		5 / 10 ALA A 400
GLU A 397
LEU A 477
ARG A 221
GLY A 482
 None
 1.35A 5dxbA-4i7iA:
undetectable		 5dxbA-4i7iA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 4i7i RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		4 / 6 CYH A  47
LEU A  37
HIS A 181
LEU A 180
 None
 0.93A 5hpuC-4i7iA:
undetectable
5hpuD-4i7iA:
undetectable		 5hpuC-4i7iA:
3.18
5hpuD-4i7iA:
4.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 4i7i RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		3 / 3 GLU A  70
ARG A 110
TYR A 117
 None
 0.66A 5trqB-4i7iA:
undetectable		 5trqB-4i7iA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4i7i RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		4 / 7 SER A 353
PHE A 314
VAL A 348
ILE A 377
 None
 1.21A 5vkqA-4i7iA:
undetectable
5vkqB-4i7iA:
undetectable		 5vkqA-4i7iA:
15.06
5vkqB-4i7iA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4i7i RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		4 / 7 SER A 353
PHE A 314
VAL A 348
ILE A 377
 None
 1.19A 5vkqC-4i7iA:
undetectable
5vkqD-4i7iA:
undetectable		 5vkqC-4i7iA:
15.06
5vkqD-4i7iA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4i7i RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		3 / 3 HIS A 255
GLU A 397
ASN A 473
 None
 1.02A 5wbvA-4i7iA:
undetectable		 5wbvA-4i7iA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4i7i RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		5 / 9 ALA A 400
GLU A 397
LEU A 477
ARG A 221
GLY A 482
 None
 1.38A 5wgqA-4i7iA:
undetectable		 5wgqA-4i7iA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4i7i RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		4 / 5 THR A  27
THR A 198
HIS A 181
LEU A 189
 None
 1.22A 6aphA-4i7iA:
undetectable		 6aphA-4i7iA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 4i7i RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		4 / 5 THR A  27
THR A 198
HIS A 181
LEU A 189
 None
 1.23A 6gbnB-4i7iA:
undetectable		 6gbnB-4i7iA:
21.78