SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i7u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 4i7u DIHYDRODIPICOLINATE
SYNTHASE
(Agrobacterium
sp.
H13-3) 		5 / 12 GLY A 194
ASN A 196
ILE A 204
LEU A 101
VAL A 131
 None
 1.17A 1r30A-4i7uA:
10.9		 1r30A-4i7uA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 4i7u DIHYDRODIPICOLINATE
SYNTHASE
(Agrobacterium
sp.
H13-3) 		5 / 12 GLY A 194
ASN A 196
ILE A 204
LEU A 101
VAL A 131
 None
 1.17A 1r30B-4i7uA:
7.0		 1r30B-4i7uA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 4i7u DIHYDRODIPICOLINATE
SYNTHASE
(Agrobacterium
sp.
H13-3) 		3 / 3 SER A 139
THR A 147
GLN A 112
 None
 0.80A 2fk8A-4i7uA:
undetectable		 2fk8A-4i7uA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4i7u DIHYDRODIPICOLINATE
SYNTHASE
(Agrobacterium
sp.
H13-3) 		5 / 12 ILE A  74
LEU A 101
GLY A 160
GLN A 174
ILE A 183
 None
 1.01A 2ycjA-4i7uA:
7.4		 2ycjA-4i7uA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4i7u DIHYDRODIPICOLINATE
SYNTHASE
(Agrobacterium
sp.
H13-3) 		4 / 8 GLY A 252
LEU A 271
PRO A 248
ARG A 138
 None
 1.13A 3bgdB-4i7uA:
undetectable		 3bgdB-4i7uA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 4i7u DIHYDRODIPICOLINATE
SYNTHASE
(Agrobacterium
sp.
H13-3) 		4 / 7 ARG A 261
LEU A 240
LEU A 193
ILE A 204
 None
 0.87A 3gp0A-4i7uA:
undetectable		 3gp0A-4i7uA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4i7u DIHYDRODIPICOLINATE
SYNTHASE
(Agrobacterium
sp.
H13-3) 		4 / 4 LEU A   9
PRO A  41
LEU A  39
ARG A  70
 None
 1.39A 3hcoA-4i7uA:
undetectable		 3hcoA-4i7uA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 4i7u DIHYDRODIPICOLINATE
SYNTHASE
(Agrobacterium
sp.
H13-3) 		5 / 12 VAL A  73
ILE A  74
ILE A   6
VAL A  40
PRO A  41
 None
 0.79A 3kpdC-4i7uA:
undetectable		 3kpdC-4i7uA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_D_ACTD901_0
(PYRANOSE 2-OXIDASE)		 4i7u DIHYDRODIPICOLINATE
SYNTHASE
(Agrobacterium
sp.
H13-3) 		4 / 6 SER A 186
GLN A 219
PHE A 218
ASN A 196
 None
 1.30A 3lskD-4i7uA:
undetectable		 3lskD-4i7uA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4i7u DIHYDRODIPICOLINATE
SYNTHASE
(Agrobacterium
sp.
H13-3) 		4 / 6 LEU A 275
GLU A 280
PRO A 277
ARG A 265
 None
 1.49A 3ltwA-4i7uA:
undetectable		 3ltwA-4i7uA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4i7u DIHYDRODIPICOLINATE
SYNTHASE
(Agrobacterium
sp.
H13-3) 		5 / 12 ILE A 204
GLY A 160
ILE A 130
ILE A  74
ASP A 163
 None
 0.96A 3uj6A-4i7uA:
undetectable		 3uj6A-4i7uA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4i7u DIHYDRODIPICOLINATE
SYNTHASE
(Agrobacterium
sp.
H13-3) 		4 / 4 ALA A 278
ALA A 281
ALA A 282
ALA A 285
 None
 0.12A 4oadA-4i7uA:
undetectable		 4oadA-4i7uA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4i7u DIHYDRODIPICOLINATE
SYNTHASE
(Agrobacterium
sp.
H13-3) 		4 / 4 ALA A 278
ALA A 281
ALA A 282
ALA A 285
 None
 0.10A 4oaeA-4i7uA:
0.8		 4oaeA-4i7uA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 4i7u DIHYDRODIPICOLINATE
SYNTHASE
(Agrobacterium
sp.
H13-3) 		3 / 3 ILE A   6
PRO A   7
ILE A 204
 None
 0.38A 5hw8F-4i7uA:
undetectable		 5hw8F-4i7uA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 4i7u DIHYDRODIPICOLINATE
SYNTHASE
(Agrobacterium
sp.
H13-3) 		4 / 6 GLN A  31
VAL A  73
LEU A 257
PRO A  12
 None
 1.24A 6brdB-4i7uA:
undetectable		 6brdB-4i7uA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 4i7u DIHYDRODIPICOLINATE
SYNTHASE
(Agrobacterium
sp.
H13-3) 		5 / 12 GLY A 187
LEU A 185
THR A 104
ASN A 196
GLN A 174
 None
 1.07A 6gngA-4i7uA:
undetectable		 6gngA-4i7uA:
22.28