SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i7z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4i7z APOCYTOCHROME F
(Mastigocladus
laminosus) 		5 / 12 VAL C 116
GLY C 117
LEU C 119
VAL C  98
PHE C 103
 None
 1.44A 1a27A-4i7zC:
undetectable		 1a27A-4i7zC:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4i7z APOCYTOCHROME F
(Mastigocladus
laminosus) 		3 / 3 GLN C 159
HIS C  26
ARG C 155
 None
HEM  C 301 (-3.4A)
None
 0.78A 1zlqA-4i7zC:
undetectable		 1zlqA-4i7zC:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4i7z APOCYTOCHROME F
(Mastigocladus
laminosus) 		5 / 6 PHE C 129
LEU C 119
PRO C   2
ALA C  74
LEU C 115
 None
None
HEM  C 301 ( 3.7A)
HEM  C 301 (-4.8A)
None
 1.40A 2vcvB-4i7zC:
undetectable		 2vcvB-4i7zC:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 4i7z APOCYTOCHROME F
(Mastigocladus
laminosus) 		4 / 8 LEU C 151
ALA C  74
LEU C  76
VAL C  72
 None
HEM  C 301 (-4.8A)
None
HEM  C 301 (-4.9A)
 0.95A 4ik6B-4i7zC:
undetectable		 4ik6B-4i7zC:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 4i7z APOCYTOCHROME F
(Mastigocladus
laminosus) 		4 / 4 THR C 181
GLY C 178
ASP C 202
SER C 198
 None
 1.36A 4rfqA-4i7zC:
undetectable		 4rfqA-4i7zC:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 4i7z APOCYTOCHROME F
(Mastigocladus
laminosus) 		4 / 5 LEU C  76
ALA C  74
LEU C 114
VAL C  72
 None
HEM  C 301 (-4.8A)
None
HEM  C 301 (-4.9A)
 0.97A 5cr1A-4i7zC:
undetectable		 5cr1A-4i7zC:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 4i7z APOCYTOCHROME F
(Mastigocladus
laminosus) 		5 / 12 LEU C  41
PRO C 252
VAL C 255
ILE C 259
ALA C 260
 None
None
None
None
OZ2  C 303 ( 4.3A)
 0.82A 5j2tC-4i7zC:
undetectable		 5j2tC-4i7zC:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 4i7z APOCYTOCHROME F
(Mastigocladus
laminosus) 		4 / 6 GLY C  81
GLU C  80
TYR C 147
ILE C 247
 None
 0.94A 5kmfA-4i7zC:
undetectable
5kmfC-4i7zC:
undetectable		 5kmfA-4i7zC:
21.05
5kmfC-4i7zC:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4i7z APOCYTOCHROME F
(Mastigocladus
laminosus) 		5 / 12 GLY C 152
VAL C  50
VAL C  34
PHE C 129
VAL C 113
 None
 1.19A 5n0oA-4i7zC:
undetectable		 5n0oA-4i7zC:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4i7z APOCYTOCHROME F
(Mastigocladus
laminosus) 		5 / 12 GLY C 152
VAL C  50
VAL C  34
PHE C 129
VAL C 113
 None
 1.22A 5n0rA-4i7zC:
undetectable		 5n0rA-4i7zC:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4i7z APOCYTOCHROME F
(Mastigocladus
laminosus) 		5 / 10 GLY C 214
GLY C  65
LYS C 194
ASN C 169
PHE C 172
 None
 1.46A 6nqaK-4i7zC:
undetectable		 6nqaK-4i7zC:
20.24