SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i83'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 4i83 3-HYDROXYACYL-[ACYL-
CARRIER-PROTEIN]
DEHYDRATASE FABZ
(Neisseria
meningitidis) 		3 / 3 GLN A  49
TYR A  20
ARG A  19
 None
 0.85A 1gtbA-4i83A:
undetectable		 1gtbA-4i83A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCF_A_ESTA596_1
(ESTROGEN RECEPTOR)		 4i83 3-HYDROXYACYL-[ACYL-
CARRIER-PROTEIN]
DEHYDRATASE FABZ
(Neisseria
meningitidis) 		5 / 10 MET A  60
LEU A  64
ALA A  68
LEU A  25
LEU A 110
 None
 1.37A 2ocfA-4i83A:
undetectable		 2ocfA-4i83A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 4i83 3-HYDROXYACYL-[ACYL-
CARRIER-PROTEIN]
DEHYDRATASE FABZ
(Neisseria
meningitidis) 		5 / 11 ALA A  70
ILE A  66
ALA A 140
ALA A 128
VAL A 114
 None
 1.10A 2qhfA-4i83A:
undetectable		 2qhfA-4i83A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4i83 3-HYDROXYACYL-[ACYL-
CARRIER-PROTEIN]
DEHYDRATASE FABZ
(Neisseria
meningitidis) 		5 / 10 PHE A  50
PHE A  54
VAL A 138
PHE A 100
VAL A  63
 None
 1.42A 3u9fR-4i83A:
undetectable		 3u9fR-4i83A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 4i83 3-HYDROXYACYL-[ACYL-
CARRIER-PROTEIN]
DEHYDRATASE FABZ
(Neisseria
meningitidis) 		4 / 6 LEU A  76
GLU A  81
ILE A 142
PRO A  17
 None
 0.96A 4xi3C-4i83A:
undetectable		 4xi3C-4i83A:
18.81