SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i84'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA2_0
(ACTINOMYCIN D)		 4i84 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		4 / 4 THR A  32
PRO A  30
THR A  31
PRO A  52
 None
 1.24A 1a7yA-4i84A:
undetectable
1a7yC-4i84A:
undetectable		 1a7yA-4i84A:
3.38
1a7yC-4i84A:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4i84 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 12 GLY A  72
GLY A  93
GLN A  71
THR A  91
GLN A  43
 None
 1.36A 2azxB-4i84A:
undetectable		 2azxB-4i84A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 4i84 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 9 PHE A 148
ASN A 139
ILE A 143
ALA A 145
VAL A  98
 None
 1.28A 2drdA-4i84A:
undetectable		 2drdA-4i84A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)		 4i84 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 12 GLY A  93
ALA A  94
ILE A  41
GLY A  42
ILE A  90
 None
 0.91A 3cyxB-4i84A:
undetectable		 3cyxB-4i84A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 4i84 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		4 / 7 PHE A 148
VAL A 149
ASN A 167
GLY A 168
 None
 1.13A 3kmoB-4i84A:
undetectable		 3kmoB-4i84A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4i84 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		4 / 6 PHE A 122
TYR A  81
VAL A  11
THR A  31
 None
 1.29A 3ltwA-4i84A:
undetectable		 3ltwA-4i84A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 4i84 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 10 ALA A 164
VAL A 149
ILE A 143
ILE A 205
VAL A 170
 None
 1.01A 3t3cB-4i84A:
undetectable		 3t3cB-4i84A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4i84 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		4 / 8 PHE A 178
TYR A  81
PHE A 180
ILE A 162
 None
 1.00A 4qoiA-4i84A:
undetectable
4qoiB-4i84A:
undetectable		 4qoiA-4i84A:
21.74
4qoiB-4i84A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H1E_A_VDXA501_1
(VITAMIN D3 RECEPTOR)		 4i84 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 12 PHE A 267
LEU A 246
ILE A 211
SER A 257
VAL A 200
 None
 1.43A 5h1eA-4i84A:
undetectable		 5h1eA-4i84A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4i84 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		4 / 6 GLY A 209
THR A 235
ASN A 241
LYS A 236
 None
 1.11A 5xxiA-4i84A:
undetectable		 5xxiA-4i84A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_A_68HA504_0
(BETA-1 ADRENERGIC
RECEPTOR)		 4i84 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 12 THR A  24
VAL A  16
SER A   7
PHE A  39
ASN A  60
 None
 1.33A 6h7mA-4i84A:
undetectable		 6h7mA-4i84A:
13.38