SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i8i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4i8i HYPOTHETICAL PROTEIN
(Bacteroides
uniformis) 		4 / 4 ILE A  80
LEU A 154
VAL A 120
ILE A  37
 None
 0.87A 1fm6D-4i8iA:
undetectable		 1fm6D-4i8iA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 4i8i HYPOTHETICAL PROTEIN
(Bacteroides
uniformis) 		4 / 8 ALA A 207
GLY A 205
THR A 206
GLN A 158
 None
 0.94A 3rglA-4i8iA:
undetectable		 3rglA-4i8iA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4i8i HYPOTHETICAL PROTEIN
(Bacteroides
uniformis) 		5 / 12 GLN A  43
HIS A 226
ASP A 223
GLY A  69
SER A 127
 None
 1.17A 3sueD-4i8iA:
undetectable		 3sueD-4i8iA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 4i8i HYPOTHETICAL PROTEIN
(Bacteroides
uniformis) 		5 / 12 PHE A  41
ASP A 223
ILE A 216
ALA A 271
ALA A  45
 ACT  A 300 (-3.7A)
None
None
None
None
 1.29A 3ua1A-4i8iA:
undetectable		 3ua1A-4i8iA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i8i HYPOTHETICAL PROTEIN
(Bacteroides
uniformis) 		4 / 8 SER A 214
GLY A 232
ALA A 270
HIS A 219
 None
 0.87A 5eezL-4i8iA:
undetectable
5eezV-4i8iA:
undetectable		 5eezL-4i8iA:
16.42
5eezV-4i8iA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i8i HYPOTHETICAL PROTEIN
(Bacteroides
uniformis) 		4 / 8 SER A 214
GLY A 232
ALA A 270
HIS A 219
 None
 0.87A 5ef1L-4i8iA:
undetectable
5ef1V-4i8iA:
undetectable		 5ef1L-4i8iA:
16.42
5ef1V-4i8iA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4i8i HYPOTHETICAL PROTEIN
(Bacteroides
uniformis) 		4 / 8 SER A 214
GLY A 232
ALA A 270
HIS A 219
 None
 0.87A 5ef2L-4i8iA:
undetectable
5ef2V-4i8iA:
undetectable		 5ef2L-4i8iA:
16.42
5ef2V-4i8iA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 4i8i HYPOTHETICAL PROTEIN
(Bacteroides
uniformis) 		3 / 3 TRP A 160
ILE A 185
SER A 127
 None
 0.66A 5gqbA-4i8iA:
2.7		 5gqbA-4i8iA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 4i8i HYPOTHETICAL PROTEIN
(Bacteroides
uniformis) 		3 / 3 ARG A 233
HIS A 226
ARG A 222
 None
 0.97A 5iaoC-4i8iA:
1.4		 5iaoC-4i8iA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 4i8i HYPOTHETICAL PROTEIN
(Bacteroides
uniformis) 		3 / 3 ARG A 233
HIS A 226
ARG A 222
 None
 0.97A 5iaoF-4i8iA:
1.4		 5iaoF-4i8iA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 4i8i HYPOTHETICAL PROTEIN
(Bacteroides
uniformis) 		5 / 6 ILE A 106
MET A  66
ALA A 109
LEU A 110
ILE A 118
 None
 1.36A 5mvmB-4i8iA:
undetectable
5mvmC-4i8iA:
undetectable		 5mvmB-4i8iA:
14.44
5mvmC-4i8iA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 4i8i HYPOTHETICAL PROTEIN
(Bacteroides
uniformis) 		4 / 4 LEU A  35
MET A 155
ILE A  62
LEU A 244
 None
 1.35A 5nfpA-4i8iA:
undetectable		 5nfpA-4i8iA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 4i8i HYPOTHETICAL PROTEIN
(Bacteroides
uniformis) 		3 / 3 VAL A 153
LYS A  33
MET A  61
 None
 0.92A 5nknA-4i8iA:
undetectable		 5nknA-4i8iA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 4i8i HYPOTHETICAL PROTEIN
(Bacteroides
uniformis) 		5 / 12 PHE A  41
ASP A 223
ILE A 216
ALA A 271
ALA A  45
 ACT  A 300 (-3.7A)
None
None
None
None
 1.25A 5vcgA-4i8iA:
undetectable		 5vcgA-4i8iA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA609_0
(ALPHA-AMYLASE)		 4i8i HYPOTHETICAL PROTEIN
(Bacteroides
uniformis) 		4 / 7 GLY A 205
TRP A 160
MET A 179
TYR A 182
 None
 1.50A 6ag0A-4i8iA:
undetectable		 6ag0A-4i8iA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC609_0
(ALPHA-AMYLASE)		 4i8i HYPOTHETICAL PROTEIN
(Bacteroides
uniformis) 		4 / 7 GLY A 205
TRP A 160
MET A 179
TYR A 182
 None
 1.50A 6ag0C-4i8iA:
2.5		 6ag0C-4i8iA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 4i8i HYPOTHETICAL PROTEIN
(Bacteroides
uniformis) 		5 / 12 ASN A 142
ILE A 144
ILE A 106
VAL A 120
ILE A  37
 None
 1.07A 6hlpA-4i8iA:
3.5		 6hlpA-4i8iA:
18.74