SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i8o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E6W_C_ESTC302_1
(SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4i8o TOXIN RNLA
(Escherichia
coli) 		4 / 4 ALA A  86
GLN A  72
TYR A  73
LEU A  10
 None
 1.41A 1e6wC-4i8oA:
undetectable		 1e6wC-4i8oA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCF_A_ESTA596_1
(ESTROGEN RECEPTOR)		 4i8o TOXIN RNLA
(Escherichia
coli) 		5 / 10 LEU A 117
GLU A 110
LEU A 155
ARG A 133
LEU A 179
 None
 1.45A 2ocfA-4i8oA:
undetectable		 2ocfA-4i8oA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 4i8o TOXIN RNLA
(Escherichia
coli) 		5 / 12 LEU A 255
LEU A 179
LEU A 188
GLY A 234
LEU A 230
 None
 1.03A 2ouzA-4i8oA:
undetectable		 2ouzA-4i8oA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 4i8o TOXIN RNLA
(Escherichia
coli) 		4 / 8 LEU A 292
LEU A 262
LYS A 263
LEU A 269
 None
 0.88A 2xn3A-4i8oA:
undetectable
2xn3B-4i8oA:
undetectable		 2xn3A-4i8oA:
23.62
2xn3B-4i8oA:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 4i8o TOXIN RNLA
(Escherichia
coli) 		3 / 3 MET A 103
GLU A  99
ASP A 246
 None
 0.97A 3a25A-4i8oA:
undetectable		 3a25A-4i8oA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 4i8o TOXIN RNLA
(Escherichia
coli) 		3 / 3 LEU A  85
GLU A  20
ILE A  17
 None
 0.42A 3czhA-4i8oA:
undetectable		 3czhA-4i8oA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 4i8o TOXIN RNLA
(Escherichia
coli) 		5 / 11 LEU A 117
LEU A 114
GLU A 110
ARG A 133
LEU A 179
 None
 1.31A 3hm1B-4i8oA:
2.2		 3hm1B-4i8oA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLL_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4i8o TOXIN RNLA
(Escherichia
coli) 		5 / 10 LEU A 117
LEU A 114
GLU A 110
ARG A 133
LEU A 179
 None
 1.42A 3ollA-4i8oA:
undetectable		 3ollA-4i8oA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLL_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 4i8o TOXIN RNLA
(Escherichia
coli) 		5 / 9 LEU A 117
LEU A 114
GLU A 110
ARG A 133
LEU A 179
 None
 1.42A 3ollB-4i8oA:
0.0		 3ollB-4i8oA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 4i8o TOXIN RNLA
(Escherichia
coli) 		3 / 3 ASN A  11
GLU A  97
ARG A 167
 None
 1.00A 3wxoA-4i8oA:
0.9		 3wxoA-4i8oA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 4i8o TOXIN RNLA
(Escherichia
coli) 		3 / 3 LEU A 169
ARG A 173
ARG A 194
 None
 0.96A 4yiaB-4i8oA:
undetectable		 4yiaB-4i8oA:
8.81