SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i8p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 10 GLY A 365
ALA A 354
THR A 380
ILE A 361
GLY A 398
None
0.98A 1c9sN-4i8pA:
undetectable
1c9sO-4i8pA:
undetectable
1c9sN-4i8pA:
9.81
1c9sO-4i8pA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 11 GLY A 365
ALA A 354
THR A 380
ILE A 361
GLY A 398
None
0.99A 1c9sP-4i8pA:
undetectable
1c9sQ-4i8pA:
undetectable
1c9sP-4i8pA:
9.81
1c9sQ-4i8pA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 9 GLY A 365
ALA A 354
THR A 380
ILE A 361
GLY A 398
None
0.97A 1c9sQ-4i8pA:
undetectable
1c9sR-4i8pA:
undetectable
1c9sQ-4i8pA:
9.81
1c9sR-4i8pA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 10 GLY A 398
GLY A 365
ALA A 354
THR A 380
ILE A 361
None
0.97A 1c9sL-4i8pA:
undetectable
1c9sV-4i8pA:
undetectable
1c9sL-4i8pA:
9.81
1c9sV-4i8pA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 10 ALA A 184
LEU A 208
LEU A 199
ALA A 200
ILE A 174
None
1.12A 1g5yC-4i8pA:
undetectable
1g5yC-4i8pA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 9 GLY A 398
GLY A 365
ALA A 354
THR A 380
ILE A 361
None
0.93A 1gtfD-4i8pA:
undetectable
1gtfE-4i8pA:
undetectable
1gtfD-4i8pA:
9.81
1gtfE-4i8pA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 10 GLY A 398
GLY A 365
ALA A 354
THR A 380
ILE A 361
None
0.93A 1gtfJ-4i8pA:
undetectable
1gtfK-4i8pA:
undetectable
1gtfJ-4i8pA:
9.81
1gtfK-4i8pA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 11 GLY A 365
ALA A 354
THR A 380
ILE A 361
GLY A 398
None
0.98A 1gtfQ-4i8pA:
undetectable
1gtfR-4i8pA:
undetectable
1gtfQ-4i8pA:
9.81
1gtfR-4i8pA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 9 GLY A 365
ALA A 354
THR A 380
ILE A 361
GLY A 398
None
0.99A 1gtfR-4i8pA:
undetectable
1gtfS-4i8pA:
undetectable
1gtfR-4i8pA:
9.81
1gtfS-4i8pA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 11 GLY A 365
ALA A 354
THR A 380
ILE A 361
GLY A 398
None
0.98A 1gtfS-4i8pA:
undetectable
1gtfT-4i8pA:
undetectable
1gtfS-4i8pA:
9.81
1gtfT-4i8pA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 11 GLY A 365
ALA A 354
THR A 380
ILE A 361
GLY A 398
None
0.96A 1gtnT-4i8pA:
undetectable
1gtnU-4i8pA:
undetectable
1gtnT-4i8pA:
9.81
1gtnU-4i8pA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 12 GLY A 398
GLY A 365
ALA A 354
THR A 380
ILE A 361
None
0.97A 1gtnL-4i8pA:
undetectable
1gtnV-4i8pA:
undetectable
1gtnL-4i8pA:
9.81
1gtnV-4i8pA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_E_TRPE81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 10 GLY A 365
ALA A 354
THR A 380
ILE A 361
GLY A 398
None
0.96A 1utdE-4i8pA:
undetectable
1utdF-4i8pA:
undetectable
1utdE-4i8pA:
9.81
1utdF-4i8pA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 10 GLY A 365
ALA A 354
THR A 380
ILE A 361
GLY A 398
None
0.92A 1utdH-4i8pA:
undetectable
1utdI-4i8pA:
undetectable
1utdH-4i8pA:
9.81
1utdI-4i8pA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 12 GLY A 365
ALA A 354
THR A 380
ILE A 361
GLY A 398
None
0.97A 1utdL-4i8pA:
undetectable
1utdM-4i8pA:
undetectable
1utdL-4i8pA:
9.81
1utdM-4i8pA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 12 GLY A 365
ALA A 354
THR A 380
ILE A 361
GLY A 398
None
0.97A 1utdO-4i8pA:
undetectable
1utdP-4i8pA:
undetectable
1utdO-4i8pA:
9.81
1utdP-4i8pA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 11 GLY A 365
ALA A 354
THR A 380
ILE A 361
GLY A 398
None
0.94A 1utdP-4i8pA:
undetectable
1utdQ-4i8pA:
undetectable
1utdP-4i8pA:
9.81
1utdQ-4i8pA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 11 GLY A 365
ALA A 354
THR A 380
ILE A 361
GLY A 398
None
0.95A 1utdS-4i8pA:
undetectable
1utdT-4i8pA:
undetectable
1utdS-4i8pA:
9.81
1utdT-4i8pA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_U_TRPU81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 10 GLY A 365
ALA A 354
THR A 380
ILE A 361
GLY A 398
None
0.98A 1utdU-4i8pA:
undetectable
1utdV-4i8pA:
undetectable
1utdU-4i8pA:
9.81
1utdV-4i8pA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_V_TRPV81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 11 GLY A 398
GLY A 365
ALA A 354
THR A 380
ILE A 361
None
0.97A 1utdL-4i8pA:
undetectable
1utdV-4i8pA:
undetectable
1utdL-4i8pA:
9.81
1utdV-4i8pA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 12 GLY A 224
GLY A 218
GLU A 190
ILE A 248
PHE A 238
NAD  A 601 (-3.6A)
None
NAD  A 601 ( 2.9A)
None
NAD  A 601 (-4.6A)
1.37A 2akeA-4i8pA:
undetectable
2akeA-4i8pA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 12 GLY A 224
GLY A 218
GLU A 190
ILE A 248
PHE A 238
NAD  A 601 (-3.6A)
None
NAD  A 601 ( 2.9A)
None
NAD  A 601 (-4.6A)
1.34A 2azxB-4i8pA:
undetectable
2azxB-4i8pA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 11 GLY A 224
GLY A 218
GLU A 190
ILE A 248
PHE A 238
NAD  A 601 (-3.6A)
None
NAD  A 601 ( 2.9A)
None
NAD  A 601 (-4.6A)
1.34A 2dr2A-4i8pA:
undetectable
2dr2A-4i8pA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
4 / 6 THR A 383
GLU A 405
MET A 316
PHE A 312
None
1.14A 2w98B-4i8pA:
2.6
2w98B-4i8pA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_2
(PHOSPHOLIPASE A2)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 9 VAL A 338
GLY A 103
LYS A 104
PRO A 328
GLY A 374
None
1.49A 3bjwG-4i8pA:
undetectable
3bjwG-4i8pA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 12 ALA A 237
ILE A 248
LEU A 263
GLY A 240
TYR A 421
None
None
None
NAD  A 601 (-3.2A)
None
1.05A 3nrrA-4i8pA:
2.1
3nrrA-4i8pA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 12 ALA A 237
ILE A 248
LEU A 263
GLY A 240
TYR A 421
None
None
None
NAD  A 601 (-3.2A)
None
1.02A 3nrrB-4i8pA:
2.1
3nrrB-4i8pA:
22.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FR8_A_TNGA601_1
(ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 11 ASN A 164
LEU A 168
MET A 169
TRP A 172
SER A 297
NAD  A 601 (-3.2A)
None
NAD  A 601 ( 3.8A)
None
EDO  A 604 (-3.0A)
0.41A 4fr8A-4i8pA:
59.2
4fr8A-4i8pA:
42.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
4 / 4 ALA A  51
ALA A  54
ALA A  55
ALA A  58
None
0.09A 4oadA-4i8pA:
undetectable
4oadA-4i8pA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
4 / 4 ALA A  51
ALA A  54
ALA A  55
ALA A  58
None
0.08A 4oaeA-4i8pA:
undetectable
4oaeA-4i8pA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
3 / 3 GLY A 336
PRO A 337
GLN A 294
None
0.40A 4oltB-4i8pA:
undetectable
4oltB-4i8pA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 12 ILE A 295
CYH A 296
LEU A 423
CYH A 455
ALA A 424
None
NAD  A 601 ( 2.7A)
NAD  A 601 (-4.4A)
EDO  A 604 ( 4.0A)
None
1.00A 4p65F-4i8pA:
undetectable
4p65H-4i8pA:
undetectable
4p65K-4i8pA:
undetectable
4p65L-4i8pA:
undetectable
4p65F-4i8pA:
5.04
4p65H-4i8pA:
5.04
4p65K-4i8pA:
3.47
4p65L-4i8pA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
3 / 3 GLY A 336
PRO A 337
GLN A 294
None
0.39A 4qwpB-4i8pA:
undetectable
4qwpB-4i8pA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
3 / 3 ASP A  48
ARG A  26
PRO A  42
None
0.92A 4wanC-4i8pA:
undetectable
4wanC-4i8pA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 10 GLY A 398
GLY A 365
ALA A 354
THR A 380
ILE A 361
None
0.96A 5eevA-4i8pA:
undetectable
5eevB-4i8pA:
undetectable
5eevA-4i8pA:
9.81
5eevB-4i8pA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 10 GLY A 398
GLY A 365
ALA A 354
THR A 380
ILE A 361
None
0.96A 5eewA-4i8pA:
undetectable
5eewB-4i8pA:
undetectable
5eewA-4i8pA:
9.81
5eewB-4i8pA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 10 GLY A 398
GLY A 365
ALA A 354
THR A 380
ILE A 361
None
0.96A 5eexA-4i8pA:
undetectable
5eexB-4i8pA:
undetectable
5eexA-4i8pA:
9.81
5eexB-4i8pA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 10 GLY A 398
GLY A 365
ALA A 354
THR A 380
ILE A 361
None
0.96A 5eeyA-4i8pA:
undetectable
5eeyB-4i8pA:
undetectable
5eeyA-4i8pA:
9.81
5eeyB-4i8pA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 10 GLY A 398
GLY A 365
ALA A 354
THR A 380
ILE A 361
None
0.96A 5eezA-4i8pA:
undetectable
5eezB-4i8pA:
undetectable
5eezA-4i8pA:
9.81
5eezB-4i8pA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 10 GLY A 398
GLY A 365
ALA A 354
THR A 380
ILE A 361
None
0.96A 5ef0A-4i8pA:
undetectable
5ef0B-4i8pA:
undetectable
5ef0A-4i8pA:
9.81
5ef0B-4i8pA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 10 GLY A 398
GLY A 365
ALA A 354
THR A 380
ILE A 361
None
0.96A 5ef1A-4i8pA:
undetectable
5ef1B-4i8pA:
undetectable
5ef1A-4i8pA:
9.81
5ef1B-4i8pA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 10 GLY A 398
GLY A 365
ALA A 354
THR A 380
ILE A 361
None
0.96A 5ef2A-4i8pA:
undetectable
5ef2B-4i8pA:
undetectable
5ef2A-4i8pA:
9.81
5ef2B-4i8pA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 10 GLY A 398
GLY A 365
ALA A 354
THR A 380
ILE A 361
None
0.96A 5ef3A-4i8pA:
undetectable
5ef3B-4i8pA:
undetectable
5ef3A-4i8pA:
9.81
5ef3B-4i8pA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 12 LEU A 186
GLY A  44
LEU A  27
GLU A 190
CYH A 196
None
None
GOL  A 603 ( 4.1A)
NAD  A 601 ( 2.9A)
None
1.18A 5emlA-4i8pA:
3.8
5emlA-4i8pA:
21.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 12 ASN A 164
LEU A 168
MET A 169
TRP A 172
CYH A 296
NAD  A 601 (-3.2A)
None
NAD  A 601 ( 3.8A)
None
NAD  A 601 ( 2.7A)
0.55A 5fhzA-4i8pA:
56.4
5fhzA-4i8pA:
39.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 12 VAL A 157
ASP A 234
ALA A 177
ARG A  62
PRO A 153
None
1.40A 5hnzB-4i8pA:
undetectable
5hnzB-4i8pA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 12 VAL A 157
ASP A 234
LEU A 208
ALA A 177
PRO A 153
None
1.03A 5hnzB-4i8pA:
undetectable
5hnzB-4i8pA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
4 / 5 HIS A 230
VAL A 216
GLY A 224
ALA A 223
None
None
NAD  A 601 (-3.6A)
None
1.01A 5hwaA-4i8pA:
undetectable
5hwaA-4i8pA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 12 VAL A 157
ASP A 234
LEU A 208
ALA A 177
PRO A 153
None
1.13A 5nd2B-4i8pA:
undetectable
5nd2B-4i8pA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 12 VAL A 157
ASP A 234
LEU A 208
ALA A 177
PRO A 153
None
1.25A 5nd3B-4i8pA:
undetectable
5nd3B-4i8pA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
5 / 12 VAL A 157
ASP A 234
LEU A 208
ALA A 177
PRO A 153
None
1.16A 5syfB-4i8pA:
undetectable
5syfB-4i8pA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea
mays)
4 / 8 PRO A  42
ALA A 192
THR A 217
ALA A 200
None
NA  A 602 ( 4.6A)
None
None
0.97A 5x2tI-4i8pA:
undetectable
5x2tJ-4i8pA:
undetectable
5x2tK-4i8pA:
undetectable
5x2tL-4i8pA:
undetectable
5x2tI-4i8pA:
14.81
5x2tJ-4i8pA:
14.17
5x2tK-4i8pA:
14.81
5x2tL-4i8pA:
14.17