SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i93'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4i93 PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE
AT5G41260
(Arabidopsis
thaliana) 		5 / 9 VAL A  73
LYS A  87
LEU A 118
LEU A 130
MET A 135
 None
 0.72A 1xkkA-4i93A:
23.9		 1xkkA-4i93A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4i93 PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE
AT5G41260
(Arabidopsis
thaliana) 		4 / 5 LEU A 268
PRO A 253
ALA A 256
ILE A 260
 None
 0.93A 2aofB-4i93A:
undetectable		 2aofB-4i93A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 4i93 PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE
AT5G41260
(Arabidopsis
thaliana) 		5 / 9 LEU A 242
PHE A 238
LEU A 285
LEU A 158
ALA A 309
 None
 1.41A 2bxeA-4i93A:
undetectable		 2bxeA-4i93A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 4i93 PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE
AT5G41260
(Arabidopsis
thaliana) 		5 / 11 LEU A 293
ILE A 235
PRO A 303
ASN A 302
LEU A 246
 None
 1.33A 2ft9A-4i93A:
undetectable		 2ft9A-4i93A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4i93 PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE
AT5G41260
(Arabidopsis
thaliana) 		4 / 7 GLY A 120
GLY A 201
PHE A  89
PHE A 100
 None
 0.95A 2qwxA-4i93A:
undetectable
2qwxB-4i93A:
undetectable		 2qwxA-4i93A:
22.19
2qwxB-4i93A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4i93 PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE
AT5G41260
(Arabidopsis
thaliana) 		4 / 6 LEU A 285
ALA A 309
LEU A 306
ALA A 165
 None
 0.87A 2vcvB-4i93A:
1.1		 2vcvB-4i93A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4i93 PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE
AT5G41260
(Arabidopsis
thaliana) 		4 / 8 LEU A 285
ALA A 309
LEU A 306
ALA A 165
 None
 0.74A 2vcvP-4i93A:
undetectable		 2vcvP-4i93A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 4i93 PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE
AT5G41260
(Arabidopsis
thaliana) 		4 / 5 SER A 233
LEU A 224
GLY A 227
GLU A 222
 None
 1.18A 3aiaA-4i93A:
undetectable
3aiaB-4i93A:
undetectable		 3aiaA-4i93A:
20.79
3aiaB-4i93A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 4i93 PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE
AT5G41260
(Arabidopsis
thaliana) 		5 / 12 GLY A 201
SER A 213
THR A 214
VAL A 229
HIS A 250
 None
 1.30A 3d91B-4i93A:
undetectable		 3d91B-4i93A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4i93 PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE
AT5G41260
(Arabidopsis
thaliana) 		4 / 6 VAL A  86
ILE A  46
ILE A 131
LEU A 130
 None
 0.78A 3hegA-4i93A:
12.9		 3hegA-4i93A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4i93 PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE
AT5G41260
(Arabidopsis
thaliana) 		5 / 12 ALA A 104
LEU A 118
LEU A 110
GLY A 201
HIS A 180
 None
 0.89A 3olsA-4i93A:
undetectable		 3olsA-4i93A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4i93 PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE
AT5G41260
(Arabidopsis
thaliana) 		3 / 3 TYR A 170
LEU A 140
ARG A 114
 None
 0.75A 3sufB-4i93A:
undetectable		 3sufB-4i93A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 4i93 PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE
AT5G41260
(Arabidopsis
thaliana) 		4 / 5 ASN A 183
LEU A 241
SER A 237
LEU A 168
 None
 1.14A 4n09C-4i93A:
undetectable		 4n09C-4i93A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 4i93 PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE
AT5G41260
(Arabidopsis
thaliana) 		4 / 6 VAL A  73
ALA A  85
THR A 139
LEU A 188
 None
 0.46A 4o0uA-4i93A:
9.0		 4o0uA-4i93A:
29.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 4i93 PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE
AT5G41260
(Arabidopsis
thaliana) 		3 / 3 LEU A 162
ARG A 159
ARG A 114
 None
 0.82A 4yiaB-4i93A:
undetectable		 4yiaB-4i93A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4i93 PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE
AT5G41260
(Arabidopsis
thaliana) 		5 / 12 GLY A 209
LEU A 130
GLY A 108
LEU A 202
HIS A 180
 None
 1.26A 4ze1A-4i93A:
undetectable		 4ze1A-4i93A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 4i93 PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE
AT5G41260
(Arabidopsis
thaliana) 		4 / 4 CYH A 292
LEU A 288
LEU A 306
ALA A 309
 None
 0.97A 5hpuA-4i93A:
undetectable
5hpuB-4i93A:
undetectable		 5hpuA-4i93A:
5.68
5hpuB-4i93A:
8.30