SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i96'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 4i96 RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		5 / 11 ARG A 221
LEU A 259
GLU A 397
LEU A 477
GLY A 482
 None
 1.37A 1cmaA-4i96A:
undetectable
1cmaB-4i96A:
undetectable		 1cmaA-4i96A:
15.56
1cmaB-4i96A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 4i96 RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		4 / 6 LEU A 280
PHE A 316
TYR A 341
VAL A 348
 None
 0.93A 1ibgH-4i96A:
undetectable		 1ibgH-4i96A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 4i96 RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		5 / 12 SER A 344
PHE A 316
LEU A 262
LEU A 231
LEU A 357
 None
 1.37A 1p33C-4i96A:
undetectable		 1p33C-4i96A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 4i96 RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		4 / 5 ALA A 504
TYR A 506
ALA A 500
TYR A 497
 None
 1.07A 1xl6A-4i96A:
undetectable
1xl6B-4i96A:
undetectable		 1xl6A-4i96A:
23.82
1xl6B-4i96A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 4i96 RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		4 / 5 LEU A 522
LEU A 525
LEU A 484
LEU A 486
 None
 0.77A 2ab2B-4i96A:
undetectable		 2ab2B-4i96A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 4i96 RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		4 / 4 ALA A 504
TYR A 506
ALA A 500
TYR A 497
 None
 1.09A 2wlkA-4i96A:
undetectable
2wlkB-4i96A:
undetectable		 2wlkA-4i96A:
23.82
2wlkB-4i96A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4i96 RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		4 / 7 ILE A 282
LEU A 262
ARG A 289
THR A 286
 None
 1.06A 2zxwN-4i96A:
undetectable
2zxwW-4i96A:
undetectable		 2zxwN-4i96A:
19.34
2zxwW-4i96A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4i96 RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		4 / 7 ILE A 282
LEU A 262
ARG A 289
THR A 286
 None
 1.05A 3ag4N-4i96A:
undetectable
3ag4W-4i96A:
undetectable		 3ag4N-4i96A:
19.34
3ag4W-4i96A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 4i96 RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		5 / 12 ARG A 493
GLY A 409
ALA A 408
ILE A 404
LEU A 486
 None
 1.06A 3ogqB-4i96A:
undetectable		 3ogqB-4i96A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 4i96 RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		3 / 3 THR A 232
SER A 258
ARG A 257
 None
 0.72A 3phnA-4i96A:
undetectable		 3phnA-4i96A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4i96 RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		4 / 5 LEU A 522
LEU A 525
LEU A 484
SER A 485
 None
 0.70A 3vhuA-4i96A:
undetectable		 3vhuA-4i96A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4i96 RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		4 / 6 ILE A 282
ARG A 221
THR A 391
LEU A 390
 None
 1.06A 3wg7N-4i96A:
2.4
3wg7W-4i96A:
undetectable		 3wg7N-4i96A:
19.34
3wg7W-4i96A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 4i96 RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		5 / 12 MET A 403
LEU A 410
LEU A 445
LEU A 443
GLY A 450
 None
 1.00A 4pxmA-4i96A:
undetectable		 4pxmA-4i96A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4i96 RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		5 / 11 SER A 234
THR A 286
THR A 287
GLY A 482
ALA A 235
 None
 1.50A 4qwuV-4i96A:
undetectable
4qwub-4i96A:
undetectable		 4qwuV-4i96A:
22.76
4qwub-4i96A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4i96 RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		5 / 11 SER A 234
THR A 286
THR A 287
GLY A 482
ALA A 235
 None
 1.49A 4qwuH-4i96A:
undetectable
4qwuN-4i96A:
undetectable		 4qwuH-4i96A:
22.76
4qwuN-4i96A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4i96 RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		5 / 11 LEU A 220
ARG A 221
LEU A 222
GLU A 263
LEU A 262
 None
 0.89A 4wg0B-4i96A:
undetectable
4wg0C-4i96A:
undetectable
4wg0D-4i96A:
undetectable		 4wg0B-4i96A:
4.74
4wg0C-4i96A:
4.74
4wg0D-4i96A:
4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4i96 RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		5 / 11 LEU A 220
ARG A 221
LEU A 222
GLU A 263
LEU A 262
 None
 0.88A 4wg0D-4i96A:
undetectable
4wg0E-4i96A:
undetectable
4wg0F-4i96A:
undetectable		 4wg0D-4i96A:
4.74
4wg0E-4i96A:
4.74
4wg0F-4i96A:
4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4i96 RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		5 / 11 GLU A 263
LEU A 262
LEU A 220
ARG A 221
LEU A 222
 None
 1.01A 4wg0C-4i96A:
undetectable
4wg0D-4i96A:
undetectable
4wg0E-4i96A:
undetectable		 4wg0C-4i96A:
4.74
4wg0D-4i96A:
4.74
4wg0E-4i96A:
4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4i96 RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		5 / 11 GLU A 263
LEU A 262
LEU A 220
ARG A 221
LEU A 222
 None
 0.99A 4wg0E-4i96A:
undetectable
4wg0F-4i96A:
undetectable
4wg0G-4i96A:
undetectable		 4wg0E-4i96A:
4.74
4wg0F-4i96A:
4.74
4wg0G-4i96A:
4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 4i96 RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		5 / 12 LEU A 262
LEU A 280
ILE A 282
VAL A 348
LEU A 390
 None
 0.86A 4y0sA-4i96A:
undetectable		 4y0sA-4i96A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4i96 RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		5 / 11 SER A 234
THR A 286
THR A 287
GLY A 482
ALA A 235
 None
 1.46A 5bxnV-4i96A:
undetectable
5bxnb-4i96A:
undetectable		 5bxnV-4i96A:
22.76
5bxnb-4i96A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4i96 RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		5 / 11 SER A 234
THR A 286
THR A 287
GLY A 482
ALA A 235
 None
 1.47A 5bxnH-4i96A:
undetectable
5bxnN-4i96A:
undetectable		 5bxnH-4i96A:
22.76
5bxnN-4i96A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4i96 RYANODINE RECEPTOR 1
(Oryctolagus
cuniculus) 		5 / 11 MET A 403
LEU A 410
LEU A 445
LEU A 443
GLY A 450
 None
 1.00A 5dxgB-4i96A:
undetectable		 5dxgB-4i96A:
21.99