SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i97'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4i97 DELTA CLASS 1
GLUTATHIONE
S-TRANSFERASE
(Scaptomyza
nigrita) 		4 / 5 LEU A  31
ILE A  53
SER A  10
GLY A   9
 None
GSH  A 301 (-4.2A)
GSH  A 301 ( 4.6A)
None
 1.00A 2otfA-4i97A:
undetectable		 2otfA-4i97A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4i97 DELTA CLASS 1
GLUTATHIONE
S-TRANSFERASE
(Scaptomyza
nigrita) 		4 / 5 SER A  11
TYR A 106
PHE A 204
VAL A 169
 None
 1.49A 2x7hA-4i97A:
undetectable		 2x7hA-4i97A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4i97 DELTA CLASS 1
GLUTATHIONE
S-TRANSFERASE
(Scaptomyza
nigrita) 		4 / 5 SER A  11
TYR A 106
PHE A 204
VAL A 169
 None
 1.50A 2x7hB-4i97A:
undetectable		 2x7hB-4i97A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4i97 DELTA CLASS 1
GLUTATHIONE
S-TRANSFERASE
(Scaptomyza
nigrita) 		5 / 12 THR A 191
VAL A 190
VAL A  74
ILE A  23
THR A  80
 None
 1.30A 3em0A-4i97A:
undetectable		 3em0A-4i97A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 4i97 DELTA CLASS 1
GLUTATHIONE
S-TRANSFERASE
(Scaptomyza
nigrita) 		4 / 7 SER A  11
MET A 164
ASN A 197
LEU A 161
 None
 1.12A 3lslA-4i97A:
undetectable
3lslD-4i97A:
undetectable		 3lslA-4i97A:
22.01
3lslD-4i97A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 4i97 DELTA CLASS 1
GLUTATHIONE
S-TRANSFERASE
(Scaptomyza
nigrita) 		5 / 8 LEU A  98
ASP A 101
ALA A 159
SER A  15
SER A  66
 None
None
None
None
GSH  A 301 (-2.7A)
 1.37A 3rodA-4i97A:
undetectable		 3rodA-4i97A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_B_NCAB302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 4i97 DELTA CLASS 1
GLUTATHIONE
S-TRANSFERASE
(Scaptomyza
nigrita) 		5 / 9 LEU A  98
ASP A 101
ALA A 159
SER A  15
SER A  66
 None
None
None
None
GSH  A 301 (-2.7A)
 1.44A 3rodB-4i97A:
undetectable		 3rodB-4i97A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 4i97 DELTA CLASS 1
GLUTATHIONE
S-TRANSFERASE
(Scaptomyza
nigrita) 		3 / 3 PRO A  54
THR A  55
LEU A  32
 GSH  A 301 ( 4.6A)
None
None
 0.75A 3ttrA-4i97A:
undetectable		 3ttrA-4i97A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4i97 DELTA CLASS 1
GLUTATHIONE
S-TRANSFERASE
(Scaptomyza
nigrita) 		5 / 9 THR A 191
ALA A 148
VAL A  19
ALA A 159
ASP A 101
 None
 1.19A 4qvnK-4i97A:
undetectable
4qvnL-4i97A:
undetectable		 4qvnK-4i97A:
23.48
4qvnL-4i97A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4i97 DELTA CLASS 1
GLUTATHIONE
S-TRANSFERASE
(Scaptomyza
nigrita) 		5 / 9 THR A 191
ALA A 148
VAL A  19
ALA A 159
ASP A 101
 None
 1.18A 4qvnY-4i97A:
undetectable
4qvnZ-4i97A:
undetectable		 4qvnY-4i97A:
23.48
4qvnZ-4i97A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4i97 DELTA CLASS 1
GLUTATHIONE
S-TRANSFERASE
(Scaptomyza
nigrita) 		4 / 6 ARG A  14
GLU A 168
TYR A 184
LEU A 161
 None
 1.39A 4twdF-4i97A:
undetectable
4twdG-4i97A:
undetectable		 4twdF-4i97A:
20.72
4twdG-4i97A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4i97 DELTA CLASS 1
GLUTATHIONE
S-TRANSFERASE
(Scaptomyza
nigrita) 		5 / 12 LEU A  83
ILE A  23
GLY A  78
LEU A  98
LEU A  70
 None
 1.26A 5nfjC-4i97A:
undetectable		 5nfjC-4i97A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4i97 DELTA CLASS 1
GLUTATHIONE
S-TRANSFERASE
(Scaptomyza
nigrita) 		3 / 3 GLY A 171
VAL A 135
MET A 131
 None
 0.65A 5ycpA-4i97A:
undetectable		 5ycpA-4i97A:
18.63