SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i98'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 4i98 SEGREGATION AND
CONDENSATION PROTEIN
B
(Streptococcus
pneumoniae) 		5 / 12 LEU B  39
LEU B  56
ILE B  19
ALA B  62
THR B  59
 None
 1.18A 2v0mC-4i98B:
undetectable		 2v0mC-4i98B:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4i98 SEGREGATION AND
CONDENSATION PROTEIN
A
SEGREGATION AND
CONDENSATION PROTEIN
B
(Streptococcus
pneumoniae) 		4 / 7 LEU B  87
ALA A 143
ALA B  99
PHE B 151
 None
 1.00A 2vcvG-4i98B:
undetectable		 2vcvG-4i98B:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4i98 SEGREGATION AND
CONDENSATION PROTEIN
B
(Streptococcus
pneumoniae) 		5 / 11 ILE B  19
ALA B  14
GLY B  15
GLU B  16
GLY B 114
 None
 0.74A 4e47A-4i98B:
undetectable		 4e47A-4i98B:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4i98 SEGREGATION AND
CONDENSATION PROTEIN
B
(Streptococcus
pneumoniae) 		5 / 11 ILE B  19
ALA B  14
GLY B  15
GLU B  16
GLY B 114
 None
 0.75A 4e47B-4i98B:
undetectable		 4e47B-4i98B:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4i98 SEGREGATION AND
CONDENSATION PROTEIN
B
(Streptococcus
pneumoniae) 		5 / 11 ILE B  19
ALA B  14
GLY B  15
GLU B  16
GLY B 114
 None
 0.77A 4e47C-4i98B:
undetectable		 4e47C-4i98B:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4i98 SEGREGATION AND
CONDENSATION PROTEIN
B
(Streptococcus
pneumoniae) 		5 / 11 ILE B  19
ALA B  14
GLY B  15
GLU B  16
GLY B 114
 None
 0.78A 4jdsA-4i98B:
undetectable		 4jdsA-4i98B:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4i98 SEGREGATION AND
CONDENSATION PROTEIN
B
(Streptococcus
pneumoniae) 		5 / 11 ILE B  19
ALA B  14
GLY B  15
GLU B  16
GLY B 114
 None
 0.77A 4jdsB-4i98B:
undetectable		 4jdsB-4i98B:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4i98 SEGREGATION AND
CONDENSATION PROTEIN
B
(Streptococcus
pneumoniae) 		5 / 11 ILE B  19
ALA B  14
GLY B  15
GLU B  16
GLY B 114
 None
 0.77A 4jdsC-4i98B:
undetectable		 4jdsC-4i98B:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4i98 SEGREGATION AND
CONDENSATION PROTEIN
B
(Streptococcus
pneumoniae) 		5 / 12 ILE B  19
ALA B  14
GLY B  15
GLU B  16
GLY B 114
 None
 0.77A 4jlgA-4i98B:
undetectable		 4jlgA-4i98B:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4i98 SEGREGATION AND
CONDENSATION PROTEIN
B
(Streptococcus
pneumoniae) 		5 / 11 ILE B  19
ALA B  14
GLY B  15
GLU B  16
GLY B 114
 None
 0.76A 5ayfA-4i98B:
undetectable		 5ayfA-4i98B:
21.13