SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i99'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4i99 CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		4 / 4 ILE A 135
LEU A   7
VAL A  49
ILE A 102
 None
 0.88A 1fm6D-4i99A:
undetectable		 1fm6D-4i99A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 4i99 CHROMOSOME PARTITION
PROTEIN SMC
PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 PHE C 184
ILE C 207
LEU C 188
VAL A1153
 None
 0.88A 1fslB-4i99C:
undetectable		 1fslB-4i99C:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 4i99 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		3 / 3 ARG C 195
TYR C 152
LYS C 156
 None
 0.74A 1uujB-4i99C:
undetectable		 1uujB-4i99C:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 4i99 CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		5 / 12 GLY A  27
ILE A1140
SER A1156
LEU A1157
ALA A1137
 None
 0.99A 1v2xA-4i99A:
undetectable		 1v2xA-4i99A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 4i99 CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		5 / 12 PHE A  28
GLY A  27
ILE A1140
SER A1156
LEU A1157
 None
 0.85A 1v2xA-4i99A:
undetectable		 1v2xA-4i99A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 4i99 CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		5 / 12 VAL A  82
VAL A  20
THR A  29
VAL A1152
GLY A  43
 None
 1.07A 2cbrA-4i99A:
undetectable		 2cbrA-4i99A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 4i99 CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		5 / 11 ILE A1099
PHE A1124
PHE A1096
VAL A 143
THR A1128
 None
 1.13A 2w3aA-4i99A:
undetectable		 2w3aA-4i99A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 4i99 CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		3 / 3 GLU A1117
LEU A1114
ASP A1113
 None
 0.43A 3ko0A-4i99A:
undetectable		 3ko0A-4i99A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 4i99 CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		3 / 3 GLU A1117
LEU A1114
ASP A1113
 None
 0.37A 3ko0T-4i99A:
undetectable		 3ko0T-4i99A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4i99 CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		3 / 3 VAL A  20
VAL A1149
SER A  14
 None
 0.68A 3n8xB-4i99A:
3.0		 3n8xB-4i99A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 4i99 CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		5 / 12 PHE A  28
GLY A  27
ILE A1140
SER A1156
LEU A1157
 None
 0.86A 3nk7B-4i99A:
undetectable		 3nk7B-4i99A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 4i99 CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		5 / 12 ASP A 138
PHE A  93
ILE A 129
TYR A 114
ILE A 126
 None
 1.04A 3pwwA-4i99A:
undetectable		 3pwwA-4i99A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4i99 CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		5 / 12 ASN A  41
ILE A  42
LEU A   7
VAL A 106
VAL A  82
 None
 1.02A 3rukA-4i99A:
undetectable		 3rukA-4i99A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 4i99 CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		4 / 5 THR A 149
ILE A 152
LYS A 153
GLU A1067
 None
 1.15A 4ac9C-4i99A:
undetectable		 4ac9C-4i99A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4i99 CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		4 / 5 THR A 149
ILE A 152
LYS A 153
GLU A1067
 None
 1.14A 4acaC-4i99A:
undetectable		 4acaC-4i99A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4i99 CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		4 / 5 THR A 149
ILE A 152
LYS A 153
GLU A1067
 None
 1.11A 4acbC-4i99A:
undetectable		 4acbC-4i99A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4i99 CHROMOSOME PARTITION
PROTEIN SMC
PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		4 / 8 SER A1144
GLU C 197
ILE C 198
ASN C 192
 None
 1.15A 4d33A-4i99A:
undetectable		 4d33A-4i99A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 4i99 CHROMOSOME PARTITION
PROTEIN SMC
PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 PHE C 168
ILE C 198
LEU C 188
LEU A1157
LEU A1155
 None
 1.28A 4qynB-4i99C:
undetectable		 4qynB-4i99C:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 4i99 CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		3 / 3 MET A 154
GLU A 158
LEU A 162
 None
 0.61A 4v2oB-4i99A:
undetectable		 4v2oB-4i99A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 4i99 CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		4 / 8 ILE A1127
ASP A1097
GLY A  38
ASN A  35
 None
None
PO4  A1202 (-3.3A)
None
 1.04A 5hwaA-4i99A:
undetectable		 5hwaA-4i99A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4i99 CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		5 / 12 ILE A  46
LEU A1114
PHE A1096
LEU A1079
TYR A 140
 None
 1.37A 6a93A-4i99A:
undetectable		 6a93A-4i99A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4i99 CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		4 / 5 ASP A 164
ILE A1085
PHE A1081
ASN A1043
 None
 1.16A 6a93B-4i99A:
undetectable		 6a93B-4i99A:
23.17