SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i9a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		5 / 9 LEU A 108
VAL A 154
VAL A 147
GLY A 151
LEU A  54
 None
 1.24A 1lwfA-4i9aA:
4.7		 1lwfA-4i9aA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		5 / 9 LEU A  46
PHE A 281
GLY A  56
ALA A  55
LEU A  81
 None
 1.14A 1nr6A-4i9aA:
undetectable		 1nr6A-4i9aA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV5_A_65BA600_0
(REVERSE
TRANSCRIPTASE)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		5 / 10 LEU A 108
VAL A 154
VAL A 147
TRP A  73
LEU A  54
 None
 1.29A 1sv5A-4i9aA:
4.5		 1sv5A-4i9aA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		5 / 12 LEU A 167
ALA A 135
SER A 248
MET A 169
LEU A 220
 None
None
NCN  A 301 (-2.9A)
NCN  A 301 ( 4.6A)
None
 1.35A 1ya3B-4i9aA:
undetectable		 1ya3B-4i9aA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		3 / 3 PHE A  60
VAL A  71
TRP A  73
 None
 0.78A 2cc8A-4i9aA:
undetectable		 2cc8A-4i9aA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		3 / 3 PHE A  60
VAL A  71
TRP A  73
 None
 0.79A 2ccbA-4i9aA:
undetectable		 2ccbA-4i9aA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		4 / 6 LEU A 256
MET A 271
THR A 273
LEU A 272
 None
 1.08A 2dysA-4i9aA:
undetectable
2dysJ-4i9aA:
undetectable		 2dysA-4i9aA:
20.95
2dysJ-4i9aA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		4 / 6 LEU A 256
MET A 271
THR A 273
LEU A 272
 None
 1.07A 2eijA-4i9aA:
undetectable
2eijJ-4i9aA:
undetectable		 2eijA-4i9aA:
20.95
2eijJ-4i9aA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		4 / 7 SER A 248
ASP A 222
SER A 268
VAL A 266
 NCN  A 301 (-2.9A)
NCN  A 301 (-3.3A)
NCN  A 301 (-3.4A)
None
 1.06A 2hdnE-4i9aA:
undetectable
2hdnF-4i9aA:
2.2
2hdnH-4i9aA:
undetectable		 2hdnE-4i9aA:
7.94
2hdnF-4i9aA:
22.42
2hdnH-4i9aA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		4 / 7 SER A 268
VAL A 266
SER A 248
ASP A 222
 NCN  A 301 (-3.4A)
None
NCN  A 301 (-2.9A)
NCN  A 301 (-3.3A)
 1.05A 2hdnF-4i9aA:
2.4
2hdnG-4i9aA:
undetectable
2hdnH-4i9aA:
undetectable		 2hdnF-4i9aA:
22.42
2hdnG-4i9aA:
7.94
2hdnH-4i9aA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		4 / 6 SER A 248
ASP A 222
SER A 268
VAL A 266
 NCN  A 301 (-2.9A)
NCN  A 301 (-3.3A)
NCN  A 301 (-3.4A)
None
 1.04A 2hdnI-4i9aA:
undetectable
2hdnJ-4i9aA:
2.4
2hdnL-4i9aA:
2.1		 2hdnI-4i9aA:
7.94
2hdnJ-4i9aA:
22.42
2hdnL-4i9aA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		4 / 6 SER A 268
VAL A 266
SER A 248
ASP A 222
 NCN  A 301 (-3.4A)
None
NCN  A 301 (-2.9A)
NCN  A 301 (-3.3A)
 1.09A 2hdnJ-4i9aA:
2.3
2hdnK-4i9aA:
undetectable
2hdnL-4i9aA:
2.3		 2hdnJ-4i9aA:
22.42
2hdnK-4i9aA:
7.94
2hdnL-4i9aA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		3 / 3 PHE A  60
VAL A  71
TRP A  73
 None
 0.79A 2vx9A-4i9aA:
undetectable		 2vx9A-4i9aA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		4 / 6 LEU A 256
MET A 271
THR A 273
LEU A 272
 None
 1.10A 2zxwA-4i9aA:
undetectable
2zxwJ-4i9aA:
undetectable		 2zxwA-4i9aA:
20.95
2zxwJ-4i9aA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		4 / 6 LEU A 256
MET A 271
THR A 273
LEU A 272
 None
 1.05A 3abmA-4i9aA:
undetectable
3abmJ-4i9aA:
undetectable		 3abmA-4i9aA:
20.95
3abmJ-4i9aA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		4 / 6 LEU A 256
MET A 271
THR A 273
LEU A 272
 None
 1.05A 3asnA-4i9aA:
undetectable
3asnJ-4i9aA:
undetectable		 3asnA-4i9aA:
20.95
3asnJ-4i9aA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		4 / 6 LEU A 256
MET A 271
THR A 273
LEU A 272
 None
 1.04A 3asoA-4i9aA:
undetectable
3asoJ-4i9aA:
undetectable		 3asoA-4i9aA:
20.95
3asoJ-4i9aA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		4 / 7 LEU A 220
GLU A 201
ASP A 172
SER A 248
 None
NCN  A 301 (-3.6A)
None
NCN  A 301 (-2.9A)
 1.41A 3dzgA-4i9aA:
undetectable		 3dzgA-4i9aA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		5 / 7 LEU A 220
GLU A 201
ASP A 172
SER A 248
THR A 137
 None
NCN  A 301 (-3.6A)
None
NCN  A 301 (-2.9A)
NCN  A 301 ( 4.4A)
 1.50A 3dzgB-4i9aA:
2.2		 3dzgB-4i9aA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		5 / 12 VAL A 134
ALA A 157
GLY A 156
ALA A 276
LEU A 256
 None
 1.11A 3qxyA-4i9aA:
undetectable		 3qxyA-4i9aA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		5 / 11 VAL A 134
ALA A 157
GLY A 156
ALA A 276
LEU A 256
 None
 1.14A 3rc0A-4i9aA:
undetectable		 3rc0A-4i9aA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		5 / 12 VAL A 134
ALA A 157
GLY A 156
ALA A 276
LEU A 256
 None
 1.15A 3rc0B-4i9aA:
undetectable		 3rc0B-4i9aA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROP_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		4 / 6 LEU A 220
GLU A 199
SER A 248
THR A 137
 None
None
NCN  A 301 (-2.9A)
NCN  A 301 ( 4.4A)
 1.41A 3ropA-4i9aA:
2.1		 3ropA-4i9aA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		3 / 3 LYS A 171
ARG A 145
LEU A 164
 NCN  A 301 (-3.3A)
None
None
 1.34A 3v4tE-4i9aA:
undetectable		 3v4tE-4i9aA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		3 / 3 GLU A 288
ALA A 287
PHE A 286
 None
 0.65A 4v1fA-4i9aA:
undetectable		 4v1fA-4i9aA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		3 / 3 SER A  42
ALA A  44
VAL A  45
 None
 0.59A 4x1iA-4i9aA:
undetectable		 4x1iA-4i9aA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		3 / 3 LEU A 229
VAL A 245
ASP A 265
 None
 0.62A 5x23A-4i9aA:
undetectable		 5x23A-4i9aA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Sus
scrofa) 		4 / 7 SER A 268
HIS A 160
GLY A 136
LEU A 220
 NCN  A 301 (-3.4A)
NCN  A 301 (-3.5A)
None
None
 1.08A 6btxA-4i9aA:
undetectable		 6btxA-4i9aA:
21.14