SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i9c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4i9c RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE F
(Bacillus
subtilis) 		3 / 3 GLN A 217
ILE A 138
HIS A 174
 None
 0.70A 1fm9A-4i9cA:
undetectable		 1fm9A-4i9cA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4i9c RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE F
(Bacillus
subtilis) 		3 / 3 GLN A 217
ILE A 138
HIS A 174
 None
 0.70A 1k74A-4i9cA:
undetectable		 1k74A-4i9cA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 4i9c RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE F
(Bacillus
subtilis) 		3 / 3 TYR A 300
GLY A 288
PHE A 266
 None
 0.65A 2m2pB-4i9cA:
undetectable		 2m2pB-4i9cA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4i9c RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE F
(Bacillus
subtilis) 		4 / 7 TYR A 284
HIS A 285
HIS A 282
TYR A 273
 None
 1.20A 2ombC-4i9cA:
undetectable
2ombD-4i9cA:
undetectable		 2ombC-4i9cA:
18.65
2ombD-4i9cA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4i9c RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE F
(Bacillus
subtilis) 		4 / 5 LEU A  40
ILE A   5
SER A   9
GLY A  11
 None
 0.97A 2otfA-4i9cA:
undetectable		 2otfA-4i9cA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_2
(GENOME POLYPROTEIN)		 4i9c RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE F
(Bacillus
subtilis) 		4 / 4 PHE A 123
TYR A 110
VAL A 134
LEU A 131
 None
 1.24A 3keeD-4i9cA:
undetectable		 3keeD-4i9cA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4i9c RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE F
(Bacillus
subtilis) 		4 / 5 PHE A 103
TYR A 110
LEU A  98
ARG A  59
 None
 1.47A 3sudD-4i9cA:
undetectable		 3sudD-4i9cA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4i9c RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE F
(Bacillus
subtilis) 		4 / 5 PHE A 103
ILE A 132
LEU A 131
LYS A 130
 None
 1.25A 3sueC-4i9cA:
undetectable		 3sueC-4i9cA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 4i9c RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE F
(Bacillus
subtilis) 		3 / 3 GLN A 183
PHE A  24
TYR A  66
 None
 0.90A 3ucjB-4i9cA:
undetectable		 3ucjB-4i9cA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 4i9c RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE F
(Bacillus
subtilis) 		3 / 3 GLN A 183
PHE A  24
TYR A  66
 None
 0.89A 3ucjA-4i9cA:
undetectable		 3ucjA-4i9cA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4i9c RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE F
(Bacillus
subtilis) 		4 / 4 PRO A 218
LEU A 220
ILE A 179
ARG A 180
 None
 1.39A 4f4dA-4i9cA:
undetectable		 4f4dA-4i9cA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4i9c RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE F
(Bacillus
subtilis) 		4 / 6 ASN A  61
GLU A  30
GLU A  68
GLU A  71
 None
 1.26A 4mi4A-4i9cA:
undetectable		 4mi4A-4i9cA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4i9c RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE F
(Bacillus
subtilis) 		4 / 7 ASN A  61
GLU A  30
GLU A  68
GLU A  71
 None
 1.28A 4mi4A-4i9cA:
undetectable
4mi4C-4i9cA:
undetectable		 4mi4A-4i9cA:
22.05
4mi4C-4i9cA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4i9c RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE F
(Bacillus
subtilis) 		3 / 3 SER A 119
ASP A  89
ASP A  83
 None
 0.87A 4mwzA-4i9cA:
undetectable		 4mwzA-4i9cA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4i9c RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE F
(Bacillus
subtilis) 		4 / 7 GLU A 149
LEU A 230
ASN A 227
SER A 160
 None
 1.04A 4pfjA-4i9cA:
undetectable		 4pfjA-4i9cA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 4i9c RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE F
(Bacillus
subtilis) 		4 / 5 TYR A  18
PHE A  24
HIS A  60
LEU A  62
 None
 1.24A 5csyB-4i9cA:
undetectable		 5csyB-4i9cA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4i9c RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE F
(Bacillus
subtilis) 		4 / 6 ASP A 338
ARG A 115
TYR A 300
TYR A 226
 None
 1.40A 5igyA-4i9cA:
undetectable		 5igyA-4i9cA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4i9c RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE F
(Bacillus
subtilis) 		4 / 5 LEU A  99
TYR A 101
LEU A  55
TYR A  52
 None
 1.31A 5ki6A-4i9cA:
undetectable		 5ki6A-4i9cA:
18.38