SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i9r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1AV2_A_DVAA6_0 (GRAMICIDIN A)	4i9r	CELLULAR RETINOIC ACID-BINDING PROTEIN 2 (Homo sapiens)	3 / 3	ALA A 35 VAL A 33 TRP A 32	None None RET A 201 (-4.5A)	0.85A	1av2A-4i9rA: undetectable 1av2B-4i9rA: undetectable	1av2A-4i9rA: 10.48 1av2B-4i9rA: 10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1AV2_D_DVAD6_0 (GRAMICIDIN A)	4i9r	CELLULAR RETINOIC ACID-BINDING PROTEIN 2 (Homo sapiens)	3 / 3	TRP A 32 ALA A 35 VAL A 33	RET A 201 (-4.5A) None None	0.98A	1av2C-4i9rA: undetectable 1av2D-4i9rA: undetectable	1av2C-4i9rA: 10.48 1av2D-4i9rA: 10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1BDW_A_DVAA6_0 (GRAMICIDIN A)	4i9r	CELLULAR RETINOIC ACID-BINDING PROTEIN 2 (Homo sapiens)	3 / 3	ALA A 36 VAL A 33 TRP A 32	None None RET A 201 (-4.5A)	0.89A	1bdwA-4i9rA: undetectable 1bdwB-4i9rA: undetectable	1bdwA-4i9rA: 10.48 1bdwB-4i9rA: 10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1C4D_C_DVAC6_0 (GRAMICIDIN A)	4i9r	CELLULAR RETINOIC ACID-BINDING PROTEIN 2 (Homo sapiens)	3 / 3	ALA A 35 VAL A 33 TRP A 32	None None RET A 201 (-4.5A)	0.93A	1c4dC-4i9rA: undetectable 1c4dD-4i9rA: undetectable	1c4dC-4i9rA: 10.48 1c4dD-4i9rA: 10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1W5U_A_DVAA6_0 (GRAMICIDIN D)	4i9r	CELLULAR RETINOIC ACID-BINDING PROTEIN 2 (Homo sapiens)	3 / 3	ALA A 35 VAL A 33 TRP A 32	None None RET A 201 (-4.5A)	0.87A	1w5uA-4i9rA: undetectable 1w5uB-4i9rA: undetectable	1w5uA-4i9rA: 10.48 1w5uB-4i9rA: 10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1W5U_B_DVAB6_0 (GRAMICIDIN D)	4i9r	CELLULAR RETINOIC ACID-BINDING PROTEIN 2 (Homo sapiens)	3 / 3	TRP A 32 ALA A 35 VAL A 33	RET A 201 (-4.5A) None None	0.93A	1w5uA-4i9rA: undetectable 1w5uB-4i9rA: undetectable	1w5uA-4i9rA: 10.48 1w5uB-4i9rA: 10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IZQ_D_DVAD6_0 (GRAMICIDIN D)	4i9r	CELLULAR RETINOIC ACID-BINDING PROTEIN 2 (Homo sapiens)	3 / 3	TRP A 32 ALA A 35 VAL A 33	RET A 201 (-4.5A) None None	0.76A	2izqC-4i9rA: undetectable 2izqD-4i9rA: undetectable	2izqC-4i9rA: 10.48 2izqD-4i9rA: 10.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3CWK_A_REAA300_1 (CELLULAR RETINOIC ACID-BINDING PROTEIN 2)	4i9r	CELLULAR RETINOIC ACID-BINDING PROTEIN 2 (Homo sapiens)	5 / 12	PHE A 15 LEU A 19 PRO A 39 VAL A 54 THR A 56	RET A 201 (-4.4A) None RET A 201 (-4.0A) RET A 201 ( 4.8A) None	0.87A	3cwkA-4i9rA: 24.8	3cwkA-4i9rA: 96.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3L8L_B_DVAB6_0 (GRAMICIDIN D)	4i9r	CELLULAR RETINOIC ACID-BINDING PROTEIN 2 (Homo sapiens)	3 / 3	TRP A 32 ALA A 35 VAL A 33	RET A 201 (-4.5A) None None	0.83A	3l8lA-4i9rA: undetectable 3l8lB-4i9rA: undetectable	3l8lA-4i9rA: 10.48 3l8lB-4i9rA: 14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3L8L_D_DVAD6_0 (GRAMICIDIN D)	4i9r	CELLULAR RETINOIC ACID-BINDING PROTEIN 2 (Homo sapiens)	3 / 3	TRP A 32 ALA A 35 VAL A 33	RET A 201 (-4.5A) None None	0.79A	3l8lC-4i9rA: undetectable 3l8lD-4i9rA: undetectable	3l8lC-4i9rA: 10.48 3l8lD-4i9rA: 14.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5LJB_A_RTLA201_1 (RETINOL-BINDING PROTEIN 1)	4i9r	CELLULAR RETINOIC ACID-BINDING PROTEIN 2 (Homo sapiens)	4 / 8	LEU A 19 ILE A 63 TRP A 109 MET A 123	None RET A 201 ( 4.7A) RET A 201 (-3.7A) RET A 201 (-4.6A)	1.00A	5ljbA-4i9rA: 19.5	5ljbA-4i9rA: 43.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5LJC_A_RTLA201_1 (RETINOL-BINDING PROTEIN 1)	4i9r	CELLULAR RETINOIC ACID-BINDING PROTEIN 2 (Homo sapiens)	4 / 7	LEU A 19 ILE A 63 TRP A 109 MET A 123	None RET A 201 ( 4.7A) RET A 201 (-3.7A) RET A 201 (-4.6A)	1.02A	5ljcA-4i9rA: 19.6	5ljcA-4i9rA: 43.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5LJC_A_RTLA201_1 (RETINOL-BINDING PROTEIN 1)	4i9r	CELLULAR RETINOIC ACID-BINDING PROTEIN 2 (Homo sapiens)	4 / 7	LEU A 22 ILE A 63 TRP A 109 MET A 123	None RET A 201 ( 4.7A) RET A 201 (-3.7A) RET A 201 (-4.6A)	1.45A	5ljcA-4i9rA: 19.6	5ljcA-4i9rA: 43.57

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1AV2_A_DVAA6_0","GRAMICIDIN A","4i9r","CELLULAR RETINOIC ACID-BINDING PROTEIN 2","Homo sapiens",3,"ALA A  35;VAL A  33;TRP A  32","None;None;RET A 201 (-4.5A)","0.85A","1av2A-4i9rA:undetectable;1av2B-4i9rA:undetectable","1av2A-4i9rA:10.48;1av2B-4i9rA:10.48"],["1AV2_D_DVAD6_0","GRAMICIDIN A","4i9r","CELLULAR RETINOIC ACID-BINDING PROTEIN 2","Homo sapiens",3,"TRP A  32;ALA A  35;VAL A  33","RET A 201 (-4.5A);None;None","0.98A","1av2C-4i9rA:undetectable;1av2D-4i9rA:undetectable","1av2C-4i9rA:10.48;1av2D-4i9rA:10.48"],["1BDW_A_DVAA6_0","GRAMICIDIN A","4i9r","CELLULAR RETINOIC ACID-BINDING PROTEIN 2","Homo sapiens",3,"ALA A  36;VAL A  33;TRP A  32","None;None;RET A 201 (-4.5A)","0.89A","1bdwA-4i9rA:undetectable;1bdwB-4i9rA:undetectable","1bdwA-4i9rA:10.48;1bdwB-4i9rA:10.48"],["1C4D_C_DVAC6_0","GRAMICIDIN A","4i9r","CELLULAR RETINOIC ACID-BINDING PROTEIN 2","Homo sapiens",3,"ALA A  35;VAL A  33;TRP A  32","None;None;RET A 201 (-4.5A)","0.93A","1c4dC-4i9rA:undetectable;1c4dD-4i9rA:undetectable","1c4dC-4i9rA:10.48;1c4dD-4i9rA:10.48"],["1W5U_A_DVAA6_0","GRAMICIDIN D","4i9r","CELLULAR RETINOIC ACID-BINDING PROTEIN 2","Homo sapiens",3,"ALA A  35;VAL A  33;TRP A  32","None;None;RET A 201 (-4.5A)","0.87A","1w5uA-4i9rA:undetectable;1w5uB-4i9rA:undetectable","1w5uA-4i9rA:10.48;1w5uB-4i9rA:10.48"],["1W5U_B_DVAB6_0","GRAMICIDIN D","4i9r","CELLULAR RETINOIC ACID-BINDING PROTEIN 2","Homo sapiens",3,"TRP A  32;ALA A  35;VAL A  33","RET A 201 (-4.5A);None;None","0.93A","1w5uA-4i9rA:undetectable;1w5uB-4i9rA:undetectable","1w5uA-4i9rA:10.48;1w5uB-4i9rA:10.48"],["2IZQ_D_DVAD6_0","GRAMICIDIN D","4i9r","CELLULAR RETINOIC ACID-BINDING PROTEIN 2","Homo sapiens",3,"TRP A  32;ALA A  35;VAL A  33","RET A 201 (-4.5A);None;None","0.76A","2izqC-4i9rA:undetectable;2izqD-4i9rA:undetectable","2izqC-4i9rA:10.48;2izqD-4i9rA:10.48"],["3CWK_A_REAA300_1","CELLULAR RETINOIC ACID-BINDING PROTEIN 2","4i9r","CELLULAR RETINOIC ACID-BINDING PROTEIN 2","Homo sapiens",5,"PHE A  15;LEU A  19;PRO A  39;VAL A  54;THR A  56","RET A 201 (-4.4A);None;RET A 201 (-4.0A);RET A 201 ( 4.8A);None","0.87A","3cwkA-4i9rA:24.8","3cwkA-4i9rA:96.35"],["3L8L_B_DVAB6_0","GRAMICIDIN D","4i9r","CELLULAR RETINOIC ACID-BINDING PROTEIN 2","Homo sapiens",3,"TRP A  32;ALA A  35;VAL A  33","RET A 201 (-4.5A);None;None","0.83A","3l8lA-4i9rA:undetectable;3l8lB-4i9rA:undetectable","3l8lA-4i9rA:10.48;3l8lB-4i9rA:14.10"],["3L8L_D_DVAD6_0","GRAMICIDIN D","4i9r","CELLULAR RETINOIC ACID-BINDING PROTEIN 2","Homo sapiens",3,"TRP A  32;ALA A  35;VAL A  33","RET A 201 (-4.5A);None;None","0.79A","3l8lC-4i9rA:undetectable;3l8lD-4i9rA:undetectable","3l8lC-4i9rA:10.48;3l8lD-4i9rA:14.10"],["5LJB_A_RTLA201_1","RETINOL-BINDING PROTEIN 1","4i9r","CELLULAR RETINOIC ACID-BINDING PROTEIN 2","Homo sapiens",4,"LEU A  19;ILE A  63;TRP A 109;MET A 123","None;RET A 201 ( 4.7A);RET A 201 (-3.7A);RET A 201 (-4.6A)","1.00A","5ljbA-4i9rA:19.5","5ljbA-4i9rA:43.57"],["5LJC_A_RTLA201_1","RETINOL-BINDING PROTEIN 1","4i9r","CELLULAR RETINOIC ACID-BINDING PROTEIN 2","Homo sapiens",4,"LEU A  19;ILE A  63;TRP A 109;MET A 123","None;RET A 201 ( 4.7A);RET A 201 (-3.7A);RET A 201 (-4.6A)","1.02A","5ljcA-4i9rA:19.6","5ljcA-4i9rA:43.57"],["5LJC_A_RTLA201_1","RETINOL-BINDING PROTEIN 1","4i9r","CELLULAR RETINOIC ACID-BINDING PROTEIN 2","Homo sapiens",4,"LEU A  22;ILE A  63;TRP A 109;MET A 123","None;RET A 201 ( 4.7A);RET A 201 (-3.7A);RET A 201 (-4.6A)","1.45A","5ljcA-4i9rA:19.6","5ljcA-4i9rA:43.57"]]