SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i9u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 4i9u L-LACTATE
DEHYDROGENASE A
CHAIN
(Oryctolagus
cuniculus) 		6 / 9 VAL A  25
GLY A  26
ASP A  51
TYR A  82
ALA A  95
ILE A 115
 1E7  A 401 (-4.5A)
1E7  A 401 (-3.2A)
1E7  A 401 (-3.4A)
None
1E7  A 401 (-3.5A)
1E7  A 401 (-4.2A)
 0.70A 1cetA-4i9uA:
38.9		 1cetA-4i9uA:
31.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4i9u L-LACTATE
DEHYDROGENASE A
CHAIN
(Oryctolagus
cuniculus) 		4 / 8 SER A 136
ASN A 112
ILE A 115
GLY A  28
 None
None
1E7  A 401 (-4.2A)
None
 1.01A 1meiA-4i9uA:
undetectable		 1meiA-4i9uA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 4i9u L-LACTATE
DEHYDROGENASE A
CHAIN
(Oryctolagus
cuniculus) 		5 / 10 ILE A  38
LEU A 253
ALA A 259
VAL A 135
ILE A 251
 None
 1.05A 2nnjA-4i9uA:
undetectable		 2nnjA-4i9uA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4i9u L-LACTATE
DEHYDROGENASE A
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 VAL A 255
VAL A 139
SER A 136
 None
 0.75A 3n8xB-4i9uA:
undetectable		 3n8xB-4i9uA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 4i9u L-LACTATE
DEHYDROGENASE A
CHAIN
(Oryctolagus
cuniculus) 		4 / 6 GLN A 225
ARG A 176
ASP A 220
GLU A 310
 None
 1.49A 4azvA-4i9uA:
4.3		 4azvA-4i9uA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUZ_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 4i9u L-LACTATE
DEHYDROGENASE A
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 LYS A  21
PRO A  18
LYS A  75
 None
 1.48A 4duzL-4i9uA:
undetectable		 4duzL-4i9uA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV7_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 4i9u L-LACTATE
DEHYDROGENASE A
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 LYS A  21
PRO A  18
LYS A  75
 None
 1.41A 4dv7L-4i9uA:
undetectable		 4dv7L-4i9uA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4i9u L-LACTATE
DEHYDROGENASE A
CHAIN
(Oryctolagus
cuniculus) 		5 / 12 LEU A 132
ILE A 120
ILE A 119
VAL A  25
VAL A  50
 None
None
1E7  A 401 (-4.7A)
1E7  A 401 (-4.5A)
None
 0.92A 4nkvA-4i9uA:
undetectable		 4nkvA-4i9uA:
23.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 4i9u L-LACTATE
DEHYDROGENASE A
CHAIN
(Oryctolagus
cuniculus) 		8 / 9 ASP A  51
VAL A  52
TYR A  82
ALA A  95
ARG A 111
ILE A 115
PHE A 118
ILE A 119
 1E7  A 401 (-3.4A)
1E7  A 401 (-4.3A)
None
1E7  A 401 (-3.5A)
1E7  A 401 (-4.3A)
1E7  A 401 (-4.2A)
1E7  A 401 (-4.6A)
1E7  A 401 (-4.7A)
 0.61A 4oknB-4i9uA:
50.7		 4oknB-4i9uA:
93.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 4i9u L-LACTATE
DEHYDROGENASE A
CHAIN
(Oryctolagus
cuniculus) 		4 / 6 LEU A 108
ASN A 107
LEU A 142
ILE A 325
 None
 1.05A 4okxA-4i9uA:
undetectable		 4okxA-4i9uA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H1E_A_VDXA501_1
(VITAMIN D3 RECEPTOR)		 4i9u L-LACTATE
DEHYDROGENASE A
CHAIN
(Oryctolagus
cuniculus) 		5 / 12 PHE A 152
LEU A 132
SER A  88
SER A 127
VAL A  25
 None
None
None
None
1E7  A 401 (-4.5A)
 1.43A 5h1eA-4i9uA:
undetectable		 5h1eA-4i9uA:
21.45