SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4i9y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 4i9y E3 SUMO-PROTEIN
LIGASE RANBP2
(Homo
sapiens) 		5 / 12 MET A 100
PHE A   8
MET A  22
ILE A  67
PRO A   4
 None
 1.42A 1hrkB-4i9yA:
undetectable		 1hrkB-4i9yA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4i9y E3 SUMO-PROTEIN
LIGASE RANBP2
(Homo
sapiens) 		5 / 11 ILE A  67
GLY A  65
PHE A 112
PHE A   8
ILE A 158
 None
 1.33A 2y7kA-4i9yA:
undetectable		 2y7kA-4i9yA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1304_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4i9y E3 SUMO-PROTEIN
LIGASE RANBP2
(Homo
sapiens) 		5 / 10 ILE A  67
GLY A  65
PHE A 112
PHE A   8
ILE A 158
 None
 1.37A 2y7kB-4i9yA:
undetectable		 2y7kB-4i9yA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4i9y E3 SUMO-PROTEIN
LIGASE RANBP2
(Homo
sapiens) 		5 / 12 ILE A  67
GLY A  65
PHE A 112
PHE A   8
ILE A 158
 None
 1.26A 2y7kC-4i9yA:
undetectable		 2y7kC-4i9yA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4i9y E3 SUMO-PROTEIN
LIGASE RANBP2
(Homo
sapiens) 		5 / 7 ILE A  67
GLY A  65
PHE A 112
PHE A   8
ILE A 158
 None
 1.20A 2y7wC-4i9yA:
undetectable		 2y7wC-4i9yA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA1_0
(FERROCHELATASE)		 4i9y E3 SUMO-PROTEIN
LIGASE RANBP2
(Homo
sapiens) 		5 / 11 MET A 100
PHE A   8
MET A  22
ILE A  67
PRO A   4
 None
 1.47A 3aqiA-4i9yA:
undetectable		 3aqiA-4i9yA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4i9y E3 SUMO-PROTEIN
LIGASE RANBP2
(Homo
sapiens) 		5 / 9 LEU A  17
VAL A  10
VAL A  56
ILE A  52
VAL A  61
 None
None
None
None
GOL  A 201 ( 4.9A)
 1.16A 3cs9C-4i9yA:
undetectable		 3cs9C-4i9yA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 4i9y E3 SUMO-PROTEIN
LIGASE RANBP2
(Homo
sapiens) 		4 / 7 PHE A  48
GLY A  64
THR A 157
PHE A   8
 None
 0.89A 3vnsA-4i9yA:
undetectable		 3vnsA-4i9yA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_A_MIYA391_1
(TETX2 PROTEIN)		 4i9y E3 SUMO-PROTEIN
LIGASE RANBP2
(Homo
sapiens) 		5 / 10 PHE A  48
ASN A  50
GLY A  65
SER A 110
GLY A  45
 None
 1.41A 4a99A-4i9yA:
undetectable		 4a99A-4i9yA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_B_MIYB391_1
(TETX2 PROTEIN)		 4i9y E3 SUMO-PROTEIN
LIGASE RANBP2
(Homo
sapiens) 		5 / 11 PHE A  48
ASN A  50
GLY A  65
SER A 110
GLY A  45
 None
 1.40A 4a99B-4i9yA:
undetectable		 4a99B-4i9yA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC391_1
(TETX2 PROTEIN)		 4i9y E3 SUMO-PROTEIN
LIGASE RANBP2
(Homo
sapiens) 		5 / 11 PHE A  48
ASN A  50
GLY A  65
SER A 110
GLY A  45
 None
 1.40A 4a99C-4i9yA:
undetectable		 4a99C-4i9yA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD391_1
(TETX2 PROTEIN)		 4i9y E3 SUMO-PROTEIN
LIGASE RANBP2
(Homo
sapiens) 		5 / 11 PHE A  48
ASN A  50
GLY A  65
SER A 110
GLY A  45
 None
 1.39A 4a99D-4i9yA:
undetectable		 4a99D-4i9yA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 4i9y E3 SUMO-PROTEIN
LIGASE RANBP2
(Homo
sapiens) 		4 / 7 GLY A  65
GLN A 111
SER A  51
HIS A  54
 None
 1.18A 4ws0A-4i9yA:
undetectable		 4ws0A-4i9yA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4i9y E3 SUMO-PROTEIN
LIGASE RANBP2
(Homo
sapiens) 		4 / 7 ILE A  67
VAL A 139
ILE A 156
CYH A  40
 None
 1.00A 5hieC-4i9yA:
undetectable		 5hieC-4i9yA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 4i9y E3 SUMO-PROTEIN
LIGASE RANBP2
(Homo
sapiens) 		5 / 12 VAL A  61
VAL A 113
GLY A 104
THR A  73
GLY A  72
 GOL  A 201 ( 4.9A)
GOL  A 201 ( 4.2A)
None
None
None
 1.10A 6brdC-4i9yA:
undetectable		 6brdC-4i9yA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 4i9y E3 SUMO-PROTEIN
LIGASE RANBP2
(Homo
sapiens) 		4 / 7 GLN A 111
PHE A  53
VAL A 152
SER A  51
 None
 1.00A 6hu9S-4i9yA:
undetectable
6hu9q-4i9yA:
undetectable		 6hu9S-4i9yA:
18.82
6hu9q-4i9yA:
20.38