SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ia4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		5 / 12 ALA A 257
ALA A 258
GLN A 261
LEU A 110
ALA A 111
 None
 0.83A 1fbyA-4ia4A:
undetectable		 1fbyA-4ia4A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		5 / 12 ALA A 257
ALA A 258
GLN A 261
LEU A 110
ALA A 111
 None
 0.83A 1fbyB-4ia4A:
undetectable		 1fbyB-4ia4A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		5 / 12 ALA A 257
ALA A 258
GLN A 261
LEU A 110
ALA A 111
 None
 0.76A 1fm6A-4ia4A:
undetectable		 1fm6A-4ia4A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		5 / 11 GLY A 252
ALA A 256
ALA A 257
LEU A 110
VAL A 179
 None
 1.03A 1ukbA-4ia4A:
undetectable		 1ukbA-4ia4A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		5 / 12 ALA A 257
ALA A 258
GLN A 261
LEU A 110
ALA A 111
 None
 0.83A 1xdkE-4ia4A:
undetectable		 1xdkE-4ia4A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		5 / 12 ALA A 257
ALA A 258
GLN A 261
LEU A 110
ALA A 111
 None
 0.80A 1xiuA-4ia4A:
undetectable		 1xiuA-4ia4A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		5 / 12 ALA A 257
ALA A 258
GLN A 261
LEU A 110
ALA A 111
 None
 0.92A 2aclA-4ia4A:
undetectable
2aclE-4ia4A:
undetectable		 2aclA-4ia4A:
22.45
2aclE-4ia4A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		5 / 12 ALA A 257
ALA A 258
GLN A 261
LEU A 110
ALA A 111
 None
 0.87A 2aclG-4ia4A:
undetectable		 2aclG-4ia4A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		4 / 5 ALA A  41
TRP A  38
LEU A  34
ALA A  40
 None
 1.23A 2jstA-4ia4A:
undetectable
2jstB-4ia4A:
undetectable		 2jstA-4ia4A:
13.60
2jstB-4ia4A:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		5 / 9 GLY A 129
TYR A 122
THR A  48
ALA A  47
THR A  92
 None
 1.20A 2npnA-4ia4A:
undetectable		 2npnA-4ia4A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		4 / 8 ILE A 232
GLN A 242
LEU A  52
GLY A 133
 None
 0.82A 2qqcH-4ia4A:
undetectable
2qqcK-4ia4A:
undetectable		 2qqcH-4ia4A:
18.52
2qqcK-4ia4A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		3 / 3 MET A  84
VAL A 179
GLU A  44
 None
 0.90A 2x9gA-4ia4A:
undetectable		 2x9gA-4ia4A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		5 / 10 ALA A 257
ALA A 258
GLN A 261
LEU A 110
ALA A 111
 None
 0.81A 3falC-4ia4A:
undetectable		 3falC-4ia4A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		5 / 11 ALA A 257
ALA A 258
GLN A 261
LEU A 110
ALA A 111
 None
 0.90A 3fc6A-4ia4A:
undetectable		 3fc6A-4ia4A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		5 / 12 ALA A 257
ALA A 258
GLN A 261
LEU A 110
ALA A 111
 None
 0.80A 3fc6C-4ia4A:
undetectable		 3fc6C-4ia4A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		5 / 10 TRP A 239
GLY A 150
GLY A 151
ASN A 153
ILE A  60
 None
 1.28A 3fw1A-4ia4A:
undetectable		 3fw1A-4ia4A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		5 / 12 GLY A 133
GLY A 129
ILE A 232
LEU A  50
VAL A  56
 None
 1.14A 3fzgA-4ia4A:
undetectable		 3fzgA-4ia4A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		3 / 3 ASN A 222
ASN A 153
GLU A 168
 None
 0.79A 3kpdB-4ia4A:
undetectable		 3kpdB-4ia4A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		5 / 12 ALA A 257
ALA A 258
GLN A 261
LEU A 110
ALA A 111
 None
 0.72A 3oapA-4ia4A:
undetectable		 3oapA-4ia4A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		4 / 7 TRP A 239
GLY A 150
GLY A 151
ASN A 153
 None
 0.89A 4fgkB-4ia4A:
undetectable		 4fgkB-4ia4A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		5 / 12 ALA A 257
ALA A 258
GLN A 261
LEU A 110
ALA A 111
 None
 0.80A 4k6iA-4ia4A:
undetectable		 4k6iA-4ia4A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		5 / 12 ALA A 257
ALA A 258
GLN A 261
LEU A 110
ALA A 111
 None
 0.80A 4nqaH-4ia4A:
undetectable		 4nqaH-4ia4A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		5 / 12 GLY A 151
GLY A 150
ALA A 229
ILE A 221
ASN A 222
 None
 1.04A 4rtmA-4ia4A:
undetectable		 4rtmA-4ia4A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		5 / 9 ALA A  41
ALA A  43
SER A  96
ALA A  47
ALA A 125
 None
 1.33A 4twdA-4ia4A:
undetectable
4twdB-4ia4A:
undetectable
4twdC-4ia4A:
undetectable
4twdD-4ia4A:
undetectable
4twdE-4ia4A:
undetectable		 4twdA-4ia4A:
20.36
4twdB-4ia4A:
20.36
4twdC-4ia4A:
20.36
4twdD-4ia4A:
20.36
4twdE-4ia4A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_E_MZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		5 / 12 VAL A 104
LEU A 197
THR A 183
ALA A 182
PRO A 199
 None
 1.16A 4yhaE-4ia4A:
undetectable		 4yhaE-4ia4A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		5 / 12 ILE A  77
ALA A  78
GLY A 149
GLY A 218
GLY A  61
 None
 0.90A 5i73A-4ia4A:
1.9		 5i73A-4ia4A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		6 / 12 PHE A  86
GLY A 203
VAL A 104
THR A 105
ALA A 198
LEU A 197
 None
 1.44A 5kocA-4ia4A:
undetectable		 5kocA-4ia4A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		4 / 8 LEU A 197
ALA A 111
VAL A  89
HIS A 260
 None
 0.87A 5nu7A-4ia4A:
undetectable		 5nu7A-4ia4A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_A_EZLA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		5 / 10 VAL A 104
LEU A 197
THR A 183
ALA A 182
PRO A 199
 None
 1.24A 5tt3A-4ia4A:
undetectable		 5tt3A-4ia4A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_C_EZLC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		5 / 10 VAL A 104
LEU A 197
THR A 183
ALA A 182
PRO A 199
 None
 1.15A 5tt3C-4ia4A:
undetectable		 5tt3C-4ia4A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		4 / 8 VAL A 104
LEU A 197
THR A 183
ALA A 182
 None
 0.93A 5tt3H-4ia4A:
undetectable		 5tt3H-4ia4A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		5 / 12 ALA A 257
ALA A 258
GLN A 261
LEU A 110
ALA A 111
 None
 0.91A 5uanA-4ia4A:
undetectable		 5uanA-4ia4A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		4 / 5 PRO A 102
GLU A  44
ARG A 118
THR A 105
 None
 1.33A 5uxcA-4ia4A:
0.8		 5uxcA-4ia4A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		5 / 12 ALA A 257
ALA A 258
GLN A 261
LEU A 110
ALA A 111
 None
 0.86A 5z12C-4ia4A:
undetectable		 5z12C-4ia4A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		5 / 12 ALA A 257
ALA A 258
GLN A 261
LEU A 110
ALA A 111
 None
 0.70A 6a5yD-4ia4A:
undetectable		 6a5yD-4ia4A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		5 / 12 ALA A 257
ALA A 258
GLN A 261
LEU A 110
ALA A 111
 None
 0.67A 6a5zD-4ia4A:
undetectable		 6a5zD-4ia4A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ia4 AQUAPORIN
(Spinacia
oleracea) 		5 / 12 ALA A 257
ALA A 258
GLN A 261
LEU A 110
ALA A 111
 None
 0.69A 6a5zL-4ia4A:
undetectable		 6a5zL-4ia4A:
15.75