SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ia5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		5 / 11 GLU A  82
ARG A  81
LEU A 217
HIS A 206
HIS A  86
 MPD  A 604 (-3.2A)
MPD  A 605 ( 4.1A)
MPD  A 604 (-4.6A)
None
None
 1.15A 1cmaA-4ia5A:
undetectable
1cmaB-4ia5A:
undetectable		 1cmaA-4ia5A:
11.84
1cmaB-4ia5A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		4 / 6 SER A 512
GLY A  29
THR A 288
ILE A  27
 None
 0.82A 1gtnD-4ia5A:
undetectable
1gtnE-4ia5A:
undetectable		 1gtnD-4ia5A:
9.19
1gtnE-4ia5A:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		5 / 12 HIS A  86
GLU A  82
ARG A  81
LEU A 217
HIS A 206
 None
MPD  A 604 (-3.2A)
MPD  A 605 ( 4.1A)
MPD  A 604 (-4.6A)
None
 1.11A 1mj2A-4ia5A:
undetectable
1mj2B-4ia5A:
undetectable		 1mj2A-4ia5A:
11.84
1mj2B-4ia5A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		5 / 12 HIS A  86
GLU A  82
ARG A  81
LEU A 217
HIS A 206
 None
MPD  A 604 (-3.2A)
MPD  A 605 ( 4.1A)
MPD  A 604 (-4.6A)
None
 1.09A 1mj2C-4ia5A:
undetectable
1mj2D-4ia5A:
undetectable		 1mj2C-4ia5A:
11.84
1mj2D-4ia5A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		5 / 11 HIS A  86
GLU A  82
ARG A  81
LEU A 217
HIS A 206
 None
MPD  A 604 (-3.2A)
MPD  A 605 ( 4.1A)
MPD  A 604 (-4.6A)
None
 1.19A 1mjlA-4ia5A:
undetectable
1mjlB-4ia5A:
undetectable		 1mjlA-4ia5A:
11.84
1mjlB-4ia5A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		5 / 12 HIS A  86
GLU A  82
ARG A  81
LEU A 217
HIS A 206
 None
MPD  A 604 (-3.2A)
MPD  A 605 ( 4.1A)
MPD  A 604 (-4.6A)
None
 1.08A 1mjoC-4ia5A:
undetectable
1mjoD-4ia5A:
undetectable		 1mjoC-4ia5A:
11.84
1mjoD-4ia5A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		4 / 5 ASP A 283
LEU A 523
ALA A 263
LEU A 279
 None
 1.09A 1nh8A-4ia5A:
undetectable		 1nh8A-4ia5A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		4 / 7 ILE A 410
LEU A 438
MET A 458
LEU A 351
 None
 0.88A 1v55A-4ia5A:
undetectable
1v55J-4ia5A:
undetectable		 1v55A-4ia5A:
21.70
1v55J-4ia5A:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		4 / 5 LEU A 211
GLY A 210
ILE A 208
PHE A 204
 None
None
None
MPD  A 604 (-3.6A)
 0.95A 1xf1A-4ia5A:
undetectable		 1xf1A-4ia5A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		4 / 6 ALA A 234
TYR A 107
ILE A  97
LEU A 100
 None
 0.99A 1xvaA-4ia5A:
2.3
1xvaB-4ia5A:
2.1		 1xvaA-4ia5A:
20.21
1xvaB-4ia5A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		5 / 11 THR A  37
ALA A 519
SER A  30
GLY A  29
SER A 512
 None
 1.18A 2f162-4ia5A:
undetectable		 2f162-4ia5A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		5 / 11 THR A  37
ALA A 519
SER A  30
GLY A  29
SER A 512
 None
 1.18A 2f16N-4ia5A:
undetectable		 2f16N-4ia5A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		4 / 7 ASP A 504
GLY A 495
ILE A 494
PRO A 481
 None
 0.79A 2fxdB-4ia5A:
undetectable		 2fxdB-4ia5A:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		5 / 9 PHE A 178
LEU A 194
ALA A 201
LEU A 152
PHE A 169
 None
 1.20A 2vcvD-4ia5A:
1.0		 2vcvD-4ia5A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		5 / 9 PHE A 178
LEU A 194
ALA A 201
LEU A 152
PHE A 169
 None
 1.18A 2vcvE-4ia5A:
undetectable		 2vcvE-4ia5A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		5 / 9 PHE A 178
LEU A 194
ALA A 201
LEU A 152
PHE A 169
 None
 1.20A 2vcvH-4ia5A:
undetectable		 2vcvH-4ia5A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		5 / 9 PHE A 178
LEU A 194
ALA A 201
LEU A 152
PHE A 169
 None
 1.15A 2vcvI-4ia5A:
undetectable		 2vcvI-4ia5A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		5 / 10 ALA A 349
LEU A 351
LEU A 439
PHE A 390
THR A 460
 None
 1.14A 2w9sD-4ia5A:
undetectable		 2w9sD-4ia5A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		5 / 10 ALA A 349
LEU A 351
LEU A 439
PHE A 390
THR A 460
 None
 1.13A 2w9sF-4ia5A:
undetectable		 2w9sF-4ia5A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		4 / 7 ILE A 410
LEU A 438
MET A 458
LEU A 351
 None
 0.89A 3ag3A-4ia5A:
undetectable
3ag3J-4ia5A:
undetectable		 3ag3A-4ia5A:
21.70
3ag3J-4ia5A:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		4 / 8 ILE A 410
LEU A 438
MET A 458
LEU A 351
 None
 0.87A 3ag3N-4ia5A:
undetectable
3ag3W-4ia5A:
undetectable		 3ag3N-4ia5A:
21.70
3ag3W-4ia5A:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		4 / 6 ASP A 539
HIS A 207
HIS A 206
HIS A  86
 None
MPD  A 604 ( 4.9A)
None
None
 1.12A 3c0zC-4ia5A:
undetectable		 3c0zC-4ia5A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		5 / 12 LEU A 321
GLY A 290
ASP A 313
GLY A  29
VAL A 252
 None
 1.04A 3cyxA-4ia5A:
undetectable		 3cyxA-4ia5A:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		4 / 7 MET A  47
ILE A  52
TYR A  26
ILE A  27
 None
 0.90A 3hgxA-4ia5A:
undetectable		 3hgxA-4ia5A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		5 / 11 LYS A 158
GLY A 478
ASP A 325
ALA A 327
ASP A 477
 None
 1.37A 3id5B-4ia5A:
undetectable		 3id5B-4ia5A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		5 / 11 LYS A 158
GLY A 478
ASP A 325
ALA A 327
ASP A 477
 None
 1.37A 3id5F-4ia5A:
undetectable		 3id5F-4ia5A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		5 / 12 ASN A 496
GLY A  29
SER A 291
ILE A 494
THR A 515
 None
 0.88A 3iv6A-4ia5A:
2.2		 3iv6A-4ia5A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		4 / 8 SER A  36
MET A 517
ARG A  95
VAL A  39
 None
 1.23A 3jx1A-4ia5A:
undetectable
3jx1B-4ia5A:
undetectable		 3jx1A-4ia5A:
21.27
3jx1B-4ia5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		4 / 8 SER A  36
MET A 517
ARG A  95
VAL A  39
 None
 1.26A 3nlyA-4ia5A:
undetectable
3nlyB-4ia5A:
undetectable		 3nlyA-4ia5A:
21.27
3nlyB-4ia5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		4 / 8 SER A  36
MET A 517
ARG A  95
VAL A  39
 None
 1.25A 3rqlA-4ia5A:
undetectable
3rqlB-4ia5A:
undetectable		 3rqlA-4ia5A:
21.27
3rqlB-4ia5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		5 / 12 LEU A 338
SER A 342
ALA A 187
ILE A 292
PHE A 344
 None
None
MPD  A 605 ( 3.9A)
None
None
 1.17A 3w67C-4ia5A:
undetectable		 3w67C-4ia5A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		4 / 8 SER A  36
MET A 517
ARG A  95
VAL A  39
 None
 1.34A 4capA-4ia5A:
undetectable
4capB-4ia5A:
undetectable		 4capA-4ia5A:
21.27
4capB-4ia5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		4 / 8 SER A  36
MET A 517
ARG A  95
VAL A  39
 None
 1.33A 4d32A-4ia5A:
undetectable
4d32B-4ia5A:
undetectable		 4d32A-4ia5A:
21.27
4d32B-4ia5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		4 / 8 ASN A 223
PHE A 398
VAL A 407
HIS A 393
 None
 1.11A 4f5zA-4ia5A:
undetectable		 4f5zA-4ia5A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA408_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		4 / 6 TYR A 200
THR A 505
ARG A  81
PHE A  87
 None
None
MPD  A 605 ( 4.1A)
None
 1.42A 4kf9A-4ia5A:
undetectable		 4kf9A-4ia5A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		4 / 6 VAL A 530
SER A 500
ALA A 492
PHE A 286
 None
 1.10A 4nedA-4ia5A:
undetectable		 4nedA-4ia5A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		5 / 12 TYR A  94
LEU A 232
ALA A 516
GLY A  31
GLY A  29
 None
 0.91A 4rn6B-4ia5A:
undetectable		 4rn6B-4ia5A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		4 / 6 GLY A 487
GLU A 486
ASP A 325
ASP A 259
 None
 0.92A 4uckB-4ia5A:
undetectable		 4uckB-4ia5A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		4 / 8 SER A  36
MET A 517
ARG A  95
VAL A  39
 None
 1.29A 4v3yA-4ia5A:
undetectable
4v3yB-4ia5A:
undetectable		 4v3yA-4ia5A:
21.27
4v3yB-4ia5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		5 / 9 GLY A 443
TYR A 421
ILE A 449
ALA A 453
GLU A 436
 None
 1.39A 4yp2B-4ia5A:
undetectable		 4yp2B-4ia5A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		5 / 12 TYR A 471
SER A 470
ALA A 498
TRP A 315
ASN A 289
 None
 1.37A 5cxvA-4ia5A:
undetectable		 5cxvA-4ia5A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		4 / 7 ILE A 410
LEU A 438
MET A 458
LEU A 351
 None
 0.88A 5iy5A-4ia5A:
undetectable
5iy5J-4ia5A:
undetectable		 5iy5A-4ia5A:
21.70
5iy5J-4ia5A:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		4 / 6 ARG A 125
GLY A 377
THR A 391
SER A 389
 None
None
None
MPD  A 605 ( 4.1A)
 1.12A 5ny7A-4ia5A:
undetectable		 5ny7A-4ia5A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		5 / 12 LEU A 279
SER A 488
PHE A 328
LEU A 317
VAL A 287
 None
 1.18A 5tudA-4ia5A:
undetectable		 5tudA-4ia5A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		4 / 8 SER A  36
MET A 517
ARG A  95
VAL A  39
 None
 1.27A 5uo7A-4ia5A:
undetectable
5uo7B-4ia5A:
undetectable		 5uo7A-4ia5A:
21.29
5uo7B-4ia5A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		4 / 7 ILE A 410
LEU A 438
MET A 458
LEU A 351
 None
 0.90A 5zcqA-4ia5A:
undetectable
5zcqJ-4ia5A:
undetectable		 5zcqA-4ia5A:
21.70
5zcqJ-4ia5A:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		3 / 3 VAL A 506
TYR A 471
GLU A 499
 None
 0.91A 5zmqD-4ia5A:
undetectable
5zmqE-4ia5A:
undetectable		 5zmqD-4ia5A:
16.25
5zmqE-4ia5A:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		5 / 9 ASP A 416
LEU A 388
ARG A 425
VAL A 345
SER A 346
 None
 1.22A 6c2mB-4ia5A:
undetectable		 6c2mB-4ia5A:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		4 / 4 ARG A 199
GLU A 196
GLU A 499
ARG A 475
 None
 1.21A 6fk2A-4ia5A:
undetectable		 6fk2A-4ia5A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		4 / 7 ILE A 410
LEU A 438
MET A 458
LEU A 351
 None
 0.98A 6nmfA-4ia5A:
undetectable
6nmfJ-4ia5A:
undetectable		 6nmfA-4ia5A:
21.70
6nmfJ-4ia5A:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN
(Lactobacillus
acidophilus) 		4 / 7 ILE A 410
LEU A 438
MET A 458
LEU A 351
 None
 0.92A 6nmpA-4ia5A:
undetectable
6nmpJ-4ia5A:
undetectable		 6nmpA-4ia5A:
21.70
6nmpJ-4ia5A:
8.09