SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iao'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
(Saccharomyces
cerevisiae) 		5 / 6 ALA A 263
SER A 266
ASN A 345
ILE A 346
ASP A 347
 APR  A 602 (-3.3A)
None
None
None
None
 0.26A 1yc2A-4iaoA:
23.8		 1yc2A-4iaoA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
(Saccharomyces
cerevisiae) 		5 / 6 ALA A 263
SER A 266
PHE A 274
ASN A 345
ILE A 346
 APR  A 602 (-3.3A)
None
APR  A 602 (-3.5A)
None
None
 0.71A 1yc2A-4iaoA:
23.8		 1yc2A-4iaoA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
(Saccharomyces
cerevisiae) 		5 / 5 ALA A 263
PHE A 274
ASN A 345
ILE A 346
ASP A 347
 APR  A 602 (-3.3A)
APR  A 602 (-3.5A)
None
None
None
 0.59A 1yc2D-4iaoA:
23.7		 1yc2D-4iaoA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
(Saccharomyces
cerevisiae) 		5 / 7 ILE A 271
PHE A 274
ASN A 345
ILE A 346
ASP A 347
 None
APR  A 602 (-3.5A)
None
None
None
 0.47A 1yc2E-4iaoA:
26.7		 1yc2E-4iaoA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
(Saccharomyces
cerevisiae) 		6 / 7 ALA A 263
SER A 266
ILE A 271
ASN A 345
ILE A 346
ASP A 347
 APR  A 602 (-3.3A)
None
None
None
None
None
 0.48A 1yc5A-4iaoA:
20.9		 1yc5A-4iaoA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
(Saccharomyces
cerevisiae) 		4 / 7 SER A 266
ILE A 271
ASP A 273
ASP A 347
 None
None
APR  A 602 (-3.9A)
None
 0.84A 1yc5A-4iaoA:
20.9		 1yc5A-4iaoA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
(Saccharomyces
cerevisiae) 		5 / 5 ALA A 263
ILE A 271
ASN A 345
ILE A 346
ASP A 347
 APR  A 602 (-3.3A)
None
None
None
None
 0.53A 2h4jA-4iaoA:
20.7		 2h4jA-4iaoA:
21.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
(Saccharomyces
cerevisiae) 		5 / 5 ILE A 271
PRO A 272
PHE A 274
PHE A 280
ILE A 346
 None
None
APR  A 602 (-3.5A)
None
None
 0.32A 2hjhA-4iaoA:
44.7		 2hjhA-4iaoA:
99.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HJH_B_NCAB901_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 271
PRO A 272
PHE A 274
VAL A 315
 None
None
APR  A 602 (-3.5A)
None
 0.43A 2hjhB-4iaoA:
44.1		 2hjhB-4iaoA:
99.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 471
GLY A 264
VAL A 500
LEU A 494
 APR  A 602 (-3.7A)
APR  A 602 (-3.3A)
None
None
 0.79A 2oa1B-4iaoA:
2.6		 2oa1B-4iaoA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 467
SER A 266
SER A 323
ASN A 345
ASN A 341
 None
 1.50A 2y00A-4iaoA:
undetectable		 2y00A-4iaoA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_A_CTCA1385_0
(TETX2 PROTEIN)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
(Saccharomyces
cerevisiae) 		5 / 10 MET A 314
PHE A 280
GLY A 279
PRO A 292
GLY A 288
 None
 1.41A 2y6rA-4iaoA:
3.7		 2y6rA-4iaoA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_C_CTCC1385_0
(TETX2 PROTEIN)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
(Saccharomyces
cerevisiae) 		5 / 12 MET A 314
PHE A 280
GLY A 279
PRO A 292
GLY A 288
 None
 1.41A 2y6rC-4iaoA:
3.6		 2y6rC-4iaoA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 258
ARG A 340
SER A 456
ILE A 461
ALA A 477
 None
 1.16A 2zbzA-4iaoA:
undetectable		 2zbzA-4iaoA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 516
SER A 323
GLY A 471
GLY A 264
LEU A 494
 None
None
APR  A 602 (-3.7A)
APR  A 602 (-3.3A)
None
 0.95A 2zw9A-4iaoA:
2.0		 2zw9A-4iaoA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 248
ALA A 521
LEU A 332
ILE A 468
LEU A 466
 None
 1.28A 3ia4B-4iaoA:
undetectable		 3ia4B-4iaoA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 474
LEU A 260
CYH A 469
ASN A 496
 None
None
None
APR  A 602 (-3.2A)
 0.87A 3lm8B-4iaoA:
3.3
3lm8D-4iaoA:
2.9		 3lm8B-4iaoA:
18.62
3lm8D-4iaoA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 474
LEU A 260
CYH A 469
ASN A 496
 None
None
None
APR  A 602 (-3.2A)
 0.88A 3lm8A-4iaoA:
2.6
3lm8C-4iaoA:
undetectable		 3lm8A-4iaoA:
18.62
3lm8C-4iaoA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 474
LEU A 260
CYH A 469
ASN A 496
 None
None
None
APR  A 602 (-3.2A)
 0.76A 3lm8B-4iaoA:
3.0
3lm8D-4iaoA:
2.9		 3lm8B-4iaoA:
18.62
3lm8D-4iaoA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
(Saccharomyces
cerevisiae) 		5 / 11 MET A 314
PHE A 280
GLY A 279
PRO A 292
GLY A 288
 None
 1.44A 3v3nA-4iaoA:
3.4		 3v3nA-4iaoA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 280
VAL A 295
PHE A 308
ILE A 388
 None
 0.90A 3zjqA-4iaoA:
undetectable		 3zjqA-4iaoA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 280
VAL A 295
PHE A 308
ILE A 388
 None
 0.89A 3zjqB-4iaoA:
undetectable		 3zjqB-4iaoA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_B_MIYB391_1
(TETX2 PROTEIN)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
(Saccharomyces
cerevisiae) 		5 / 11 MET A 314
PHE A 280
GLY A 279
PRO A 292
GLY A 288
 None
 1.37A 4a99B-4iaoA:
3.8		 4a99B-4iaoA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 516
LEU A 260
ILE A 468
CYH A 469
 None
 0.75A 4asdA-4iaoA:
undetectable		 4asdA-4iaoA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
(Saccharomyces
cerevisiae) 		4 / 4 ASN A 345
ALA A 263
GLY A 262
THR A 472
 None
APR  A 602 (-3.3A)
APR  A 602 (-3.1A)
APR  A 602 (-4.0A)
 1.27A 4bboC-4iaoA:
undetectable		 4bboC-4iaoA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 296
HIS A 364
LEU A 449
PRO A 478
 None
APR  A 602 (-4.1A)
None
None
 0.88A 4o8zA-4iaoA:
26.2		 4o8zA-4iaoA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
(Saccharomyces
cerevisiae) 		5 / 7 ILE A 271
PHE A 274
ASN A 345
ILE A 346
ASP A 347
 None
APR  A 602 (-3.5A)
None
None
None
 0.41A 4rmjA-4iaoA:
31.5		 4rmjA-4iaoA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 251
TRP A 526
VAL A 520
ALA A 517
LEU A 325
 None
 1.20A 4rrwB-4iaoA:
undetectable		 4rrwB-4iaoA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 251
TRP A 526
VAL A 520
ALA A 517
LEU A 325
 None
 1.20A 4rrzB-4iaoA:
undetectable		 4rrzB-4iaoA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 171
GLY A 172
PHE A 141
TYR A 154
LEU A 142
 None
 1.19A 5czyA-4iaoA:
undetectable		 5czyA-4iaoA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
REGULATORY PROTEIN
SIR4
(Saccharomyces
cerevisiae) 		5 / 10 THR C 742
THR C 866
SER C 867
ALA A 477
SER A 480
 None
 1.43A 5l66K-4iaoC:
undetectable
5l66L-4iaoC:
undetectable		 5l66K-4iaoC:
18.22
5l66L-4iaoC:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
REGULATORY PROTEIN
SIR4
(Saccharomyces
cerevisiae) 		5 / 10 THR C 742
THR C 866
SER C 867
ALA A 477
SER A 480
 None
 1.43A 5l66Y-4iaoC:
undetectable
5l66Z-4iaoC:
undetectable		 5l66Y-4iaoC:
18.22
5l66Z-4iaoC:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2
REGULATORY PROTEIN
SIR4
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 PRO A 211
ILE C 832
ASP A 210
LEU A 212
ILE A 114
 None
 1.27A 5tiwB-4iaoA:
undetectable		 5tiwB-4iaoA:
20.49