SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ib2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 4ib2 PUTATIVE LIPOPROTEIN
([Ruminococcus]
gnavus) 		6 / 12 ILE A 114
ALA A 111
ILE A 250
LEU A  66
VAL A  68
LEU A  52
 None
 1.30A 1df7A-4ib2A:
undetectable		 1df7A-4ib2A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 4ib2 PUTATIVE LIPOPROTEIN
([Ruminococcus]
gnavus) 		5 / 10 PHE A  86
LEU A 257
LEU A  52
ALA A  55
VAL A  68
 None
 0.90A 2bxeA-4ib2A:
undetectable		 2bxeA-4ib2A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 4ib2 PUTATIVE LIPOPROTEIN
([Ruminococcus]
gnavus) 		4 / 8 ASP A  73
TYR A 208
TYR A  96
HIS A  93
 None
CL  A 301 (-4.6A)
MET  A 305 (-3.7A)
MET  A 305 (-3.5A)
 1.39A 2ha2A-4ib2A:
undetectable		 2ha2A-4ib2A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 4ib2 PUTATIVE LIPOPROTEIN
([Ruminococcus]
gnavus) 		4 / 8 ASP A  73
TYR A 208
TYR A  96
HIS A  93
 None
CL  A 301 (-4.6A)
MET  A 305 (-3.7A)
MET  A 305 (-3.5A)
 1.35A 2ha2B-4ib2A:
undetectable		 2ha2B-4ib2A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 4ib2 PUTATIVE LIPOPROTEIN
([Ruminococcus]
gnavus) 		4 / 6 ASN A  89
ILE A 237
GLN A  92
THR A 106
 None
 1.07A 2hkkA-4ib2A:
undetectable		 2hkkA-4ib2A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A933_1
(ANDROGEN RECEPTOR)		 4ib2 PUTATIVE LIPOPROTEIN
([Ruminococcus]
gnavus) 		5 / 10 ILE A 266
GLY A 206
ASN A 205
PHE A 119
GLU A 224
 None
None
MET  A 305 (-3.8A)
None
None
 1.28A 2piwA-4ib2A:
undetectable		 2piwA-4ib2A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ib2 PUTATIVE LIPOPROTEIN
([Ruminococcus]
gnavus) 		4 / 4 ILE A 114
GLN A  92
ILE A  51
LEU A 108
 None
 1.23A 3dzyD-4ib2A:
undetectable		 3dzyD-4ib2A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 4ib2 PUTATIVE LIPOPROTEIN
([Ruminococcus]
gnavus) 		5 / 12 ALA A 230
HIS A  48
HIS A 115
GLU A 117
LEU A 153
 None
MET  A 305 (-4.6A)
None
MET  A 305 (-2.6A)
None
 1.33A 4r7lA-4ib2A:
undetectable		 4r7lA-4ib2A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4ib2 PUTATIVE LIPOPROTEIN
([Ruminococcus]
gnavus) 		5 / 11 LEU A 257
LEU A 253
GLU A  53
LEU A  52
LEU A  66
 None
 1.10A 4wg0B-4ib2A:
undetectable
4wg0C-4ib2A:
undetectable
4wg0D-4ib2A:
undetectable		 4wg0B-4ib2A:
5.67
4wg0C-4ib2A:
5.67
4wg0D-4ib2A:
5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4ib2 PUTATIVE LIPOPROTEIN
([Ruminococcus]
gnavus) 		5 / 11 LEU A 257
LEU A 253
GLU A  53
LEU A  52
LEU A  66
 None
 1.09A 4wg0D-4ib2A:
undetectable
4wg0E-4ib2A:
undetectable
4wg0F-4ib2A:
undetectable		 4wg0D-4ib2A:
5.67
4wg0E-4ib2A:
5.67
4wg0F-4ib2A:
5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 4ib2 PUTATIVE LIPOPROTEIN
([Ruminococcus]
gnavus) 		5 / 12 ILE A  51
ILE A  58
LEU A  52
LEU A 253
LEU A  66
 None
 1.19A 5tiwA-4ib2A:
undetectable		 5tiwA-4ib2A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4ib2 PUTATIVE LIPOPROTEIN
([Ruminococcus]
gnavus) 		5 / 10 ILE A  58
VAL A  41
ALA A  88
LEU A  66
LEU A  52
 None
 0.76A 6f6nA-4ib2A:
undetectable
6f6nB-4ib2A:
undetectable		 6f6nA-4ib2A:
18.06
6f6nB-4ib2A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4ib2 PUTATIVE LIPOPROTEIN
([Ruminococcus]
gnavus) 		4 / 5 ARG A 194
ALA A 193
TYR A 208
GLN A 191
 None
None
CL  A 301 (-4.6A)
None
 1.36A 6f6sA-4ib2A:
undetectable
6f6sB-4ib2A:
undetectable		 6f6sA-4ib2A:
18.06
6f6sB-4ib2A:
16.53