SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ic5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 4ic5 PROTEASE DO-LIKE 5,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 ASN A 145
PHE A 134
VAL A 280
 None
 0.75A 1kijA-4ic5A:
undetectable		 1kijA-4ic5A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 4ic5 PROTEASE DO-LIKE 5,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 ASN A 281
GLY A 234
ILE A 233
ILE A 261
 None
 0.78A 1n49D-4ic5A:
undetectable		 1n49D-4ic5A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4ic5 PROTEASE DO-LIKE 5,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 LEU A 271
VAL A 305
ALA A 254
PHE A 298
VAL A 280
 None
 1.46A 2g70B-4ic5A:
undetectable		 2g70B-4ic5A:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 4ic5 PROTEASE DO-LIKE 5,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 VAL A  92
GLU A  88
GLU A  89
 None
None
CA  A 401 ( 3.6A)
 0.78A 2nv4A-4ic5A:
undetectable		 2nv4A-4ic5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 4ic5 PROTEASE DO-LIKE 5,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 7 PHE A 134
LEU A 189
VAL A 309
THR A 308
 None
 0.87A 2qblA-4ic5A:
undetectable		 2qblA-4ic5A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 4ic5 PROTEASE DO-LIKE 5,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 4 GLU A 200
GLY A 198
THR A 196
GLU A 197
 None
 1.23A 3e9xA-4ic5A:
undetectable		 3e9xA-4ic5A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4ic5 PROTEASE DO-LIKE 5,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 LEU A  94
ILE A 221
ALA A 220
THR A 277
 None
 0.96A 3mdrA-4ic5A:
undetectable		 3mdrA-4ic5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 4ic5 PROTEASE DO-LIKE 5,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 LYS A 179
VAL A 181
HIS A 141
 None
 1.18A 3tj7A-4ic5A:
undetectable		 3tj7A-4ic5A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 4ic5 PROTEASE DO-LIKE 5,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 133
GLY A 268
ILE A 142
ASN A 223
VAL A 103
 None
 1.07A 4fr0A-4ic5A:
undetectable		 4fr0A-4ic5A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 4ic5 PROTEASE DO-LIKE 5,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 THR A 230
THR A 232
ALA A 220
ALA A 259
ASN A 281
 None
 1.45A 4u15A-4ic5A:
undetectable		 4u15A-4ic5A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_I_PACI601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 4ic5 PROTEASE DO-LIKE 5,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 PHE A 134
ILE A 300
VAL A 306
TRP A 136
VAL A 309
 None
 1.48A 4yfbI-4ic5A:
undetectable		 4yfbI-4ic5A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 4ic5 PROTEASE DO-LIKE 5,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 4 LEU A 152
LEU A 192
GLY A 178
GLU A 177
 None
 1.22A 5hhjA-4ic5A:
undetectable		 5hhjA-4ic5A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 4ic5 PROTEASE DO-LIKE 5,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 GLU A  87
ARG A  90
PHE A 219
VAL A 235
 CA  A 402 (-2.6A)
None
None
None
 1.48A 6fgdA-4ic5A:
undetectable		 6fgdA-4ic5A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 4ic5 PROTEASE DO-LIKE 5,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 THR A  98
VAL A 102
VAL A 103
ASP A 272
ASN A 281
 None
 1.25A 6iblA-4ic5A:
undetectable		 6iblA-4ic5A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 4ic5 PROTEASE DO-LIKE 5,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 THR A  98
VAL A 102
VAL A 103
ASP A 272
ASN A 281
 None
 1.26A 6iblB-4ic5A:
undetectable		 6iblB-4ic5A:
23.11